Since the 1970s, the 2%−10% rule has been used to describe the range of interfragmentary gap closure strains that are conducive for secondary bone healing. Interpreting the available evidence for the association between strain and bone healing remains challenging because interfragmentary strain is impossible to directly measure in vivo. The question of how much strain occurs within and around the fracture gap is also difficult to resolve using bench tests with osteotomy models because these do not reflect the complexity of injury patterns seen in the clinic. To account for these challenges, we used finite element modeling to assess the three-dimensional interfragmentary strain in a case series of naturally occurring distal femur fractures treated with lateral plating under load conditions representative of the early postoperative period. Preoperative computed tomography scans were used to construct patient-specific finite element models and plate fixation constructs to match the operative management of each patient. The simulations showed that gap strains were within 2%−10% only for the lowest load application level, 20% static body weight (BW). Moderate loading of 60% static BW and above caused gap strains that far exceeded 10%, but in all cases, strains in the periosteal region external to the fracture line remained low. Comparing these findings with postoperative radiographs suggests that in vivo secondary healing of distal femur fractures may be robust to early gap strains much greater than 10% because formation of new bone is initiated outside the gap where strains are lower, followed by later consolidation within the gap.