Effect of pyrophosphate on hydroxyapatite and its implications in calcium homeostasis

Fleisch, H.; Russell, R. G. G.; Straumann, F.

Affiliations

¹Laboratory for Experimental Surgery, Schweizerisches Forschungsinstitut, Davos. Switzerland. and Institute Dr. R. Straumann. Waldenburg. Switzerland

Links

DOI: 10.1038/212901a0

PubMed: 4306793

WoS: A19668539100028

Cited By (23)

Year	Entry
1988	Delmas PD. Biochemical markers of bone turnover in osteoporosis. In: Riggs BL, Melton LJ III, eds. Osteoporosis: Etiology, Diagnosis, and Management. New York, NY: Raven Press; 1988:297-316.
2022	Tang T, Landis W, Raguin E, Werner P, Bertinetti L, Dean M, Wagermaier W, Fratzl P. A 3D network of nanochannels for possible ion and molecule transit in mineralizing bone and cartilage. Adv NanoBiomed Res. 2022;2(8):2100162.
1996	Lin JH. Bisphosphonates: a review of their pharmacokinetic properties. Bone. February 1996;18(2):75-85.
2006	Nancollas GH, Tang R, Phipps RJ, Henneman Z, Gulde S, Wu W, Mangood A, Russell RGG, Ebetino FH. Novel insights into actions of bisphosphonates on bone: differences in interactions with hydroxyapatite. Bone. May 2006;38(5):617-627.
2011	Russell RGG. Bisphosphonates: the first 40 years. Bone. July 2011;49(1):2-19.
2015	Whyte MP, Zhang F, Wenkert D, McAlister WH, Mack KE, Benigno MC, Coburn SP, Wagy S, Griffin DM, Ericson KL, Mumm S. Hypophosphatasia: validation and expansion of the clinical nosology for children from 25 years experience with 173 pediatric patients. Bone. June 2015;75:229-239.
2017	Whyte MP. Hypophosphatasia: an overview for 2017. Bone. September 2017;102:15-25.
2020	Orriss IR. Extracellular pyrophosphate: the body's “water softener”. Bone. May 2020;134:115243.
2020	Opdebeeck B, Neven E, Millán JL, Pinkerton AB, D'Haese PC, Verhulst A. Pharmacological TNAP inhibition efficiently inhibits arterial media calcification in a warfarin rat model but deserves careful consideration of potential physiological bone formation/mineralization impairment. Bone. August 2020;137:115392.
2021	Seefried L, Kishnani PS, Moseley S, Denker AE, Watsky E, Whyte MP, Dahir KM. Pharmacodynamics of asfotase alfa in adults with pediatric-onset hypophosphatasia. Bone. January 2021;142:115664.
2021	Suva LJ, Cooper A, Watts AE, Ebetino FH, Price J, Gaddy D. Bisphosphonates in veterinary medicine: the new horizon for use. Bone. January 2021;142:115711.
2021	Stürznickel J, Schmidt FN, von Vopelius E, Delsmann MM, Schmidt C, Jandl NM, Oheim R, Barvencik F. Bone healing and reactivation of remodeling under asfotase alfa therapy in adult patients with pediatric-onset hypophosphatasia. Bone. February 2021;143:115794.
2021	Sedghizadeh PP, Sun S, Jones AC, Sodagar E, Cherian P, Chen C, Junka AF, Neighbors JD, McKenna CE, Russell RGG, Ebetino FH. Bisphosphonates in dentistry: historical perspectives, adverse effects, and novel applications. Bone. June 2021;147:115933.
2021	Whyte MP, May JD, McAlister WH, Burgener K, Cortez SR, Kreienkamp R, Castro O, Verzola R, Zavala AS, McPherson CC, Gottesman GS, Ericson KL, Coburn SP, Arbelaez AM. Vitamin B₆ deficiency with normal plasma levels of pyridoxal 5′-phosphate in perinatal hypophosphatasia. Bone. September 2021;150:116007.
2022	Whyte MP, Zhang F, Wenkert D, Mack KE, Bijanki VN, Ericson KL, Coburn SP. Hypophosphatasia: vitamin B₆ status of affected children and adults. Bone. January 2022;154:116204.
2023	Bourne LE, Davies BK, Millan JL, Arnett TR, Wheeler-Jones CP, Keen JA, Roberts SJ, Orriss IR. Evidence that pyrophosphate acts as an extracellular signalling molecule to exert direct functional effects in primary cultures of osteoblasts and osteoclasts. Bone. November 2023;176:116868.
2016	Millán JL, Whyte MP. Alkaline phosphatase and hypophosphatasia. Calcif Tiss Int. April 2016;98(4):398-416.
2023	Ralph D, Levine M, Millán JL, Uitto J, Li Q. Weighing the evidence for the roles of plasma versus local pyrophosphate in ectopic calcification disorders. J Bone Miner Res. April 2023;38(4):457-463.
2008	Drake MT, Clarke BL, Khosla S. Bisphosphonates: mechanism of action and role in clinical practice. Mayo Clin Proc. September 2008;83(9):1032-1045.
2016	Whyte MP. Hypophosphatasia: aetiology, nosology, pathogenesis, diagnosis and treatment. Nat Rev Endocrinol. April 2016;12(4):233-246.
2020	Mehraban Alvandi L. Diffuse Damage Repair Mechanism in Bone [PhD thesis]. New York, NY: The City College of New York; 2020.
2016	Park M. Prevention and Treatment of Post-Traumatic Osteoarthritis [PhD thesis]. University of Delaware; 2016.
1970	Rodan GA. Blood-Bone Calcium Fluxes in the Perfused Dog Limb and the Hormonal Control of Calcium Homeostasis [PhD thesis]. Weizmann Institute of Science; 1970.