Spasticity of the upper extremity often occurs after injury to the upper motor neurons (UMN). This condition can greatly interfere with the hand positioning in space and the functional use of the arm, affecting many daily living activities including walking. As gait and balance involve the coordination of all segments of the body, the control of upper limbs movement is necessary for smooth motion and stability. The purpose of this study was to assess the effects of surgical interventions on upper extremity spasticity to gait patterns in spastic patients, as a way to assess the effect on patient’s mobility. Four patients with an anoxic brain injury, upper extremity spasticity, and an altered gait participated in this study. A specific treatment plan based on the patient was tailored by the orthopedic hand surgeon to help release the contractures and spastic muscles. Threedimensional gait analysis was performed before surgery, 3, 6, and 12 months postoperatively. During each experimental session, the patient walked at a self-selected pace in a straight line across four force plates embedded into the floor (Kistler®). Motion data were acquired using Vicon® Motion Capturing System. Spatiotemporal measurements as well as joint ranges of motion (ROM) of the hip, knee and ankle were studied. The results from matched non-disabled controls were included as reference. Overtime, clinical assessment displayed recovery in hand functions and restored sensation in the fingers in some patients. Gait analysis results demonstrated overall improvements in spatiotemporal parameters, specifically in stride time, walking speed and double support. Improvements in lower limbs joint ROM were also evident in some patients. The results of this study indicated that, within a timeframe of one year, gait patterns improved in all patients. These observations suggest that, over time, upper limb surgery have the potential to improve the biomechanics of the gait of spastic patients.