This work sought out to investigate the role disease has in disrupting the blood brain barrier. Furthermore to investigate the role this disruption plays on developing novel treatment strategies. To do this disease models of Epilepsy and of Pontine Glioma were created. In these models, disruption of the blood brain barrier was observerd using MR imaging, histology, and with in vivo pressure measurements. This data motivated new treatment strategies and resulted in new understanding of how changes in tissue structure affect drug delivery. For example, with Pontine Glioma, early treatment may not show to be efficacious due to lack of sufficient internal vasculature. Furthermore, late treatment may also prove to be impossible as vasculature begins to collapse under pressure from the surrounding tumor burden. This collapse in the vasculature at later stages may prevent the tumor core from achieving concentrations of drug that may be therapeutic. The results of this study has motivated the investigation of novel therapeutic agents, such as super-paramagnetic iron oxide nanoparticles, and development of alternate delivery strategies.