Axonal injury in head injury

Pilz, P.

Affiliations

¹Landes-Nervenklinik Salzburg, Ignaz-Harrer-Strasse 79, A-5020 Salzburg, Austria

Abstract and keywords

A histological analysis of 324 unselected fatal head injuries disclosed axonal injury in the form of retraction balls in 100 cases: this was severe in 64 and mild in 36. It is suggested that axonal injury exists as a spectrum without there necessarily being selective involvement of the corpus callosum or the rostral brain stem, and that cases with mild axonal injury may be unconscious for only a short time after their injury.

Keywords: Head injury ;traumatic coma; axonal injury

Links

DOI: 10.1007/978-3-7091-4147-2_17

PubMed: 6581700

Cited Works (3)

Year	Entry
1982	Adams JH, Graham DI, Murray LS, Scott G. Diffuse axonal injury due to nonmissile head injury in humans: an analysis of 45 cases. Ann Neurol. December 1982;12(6):557-563.
1956	Strich SJ. Diffuse degeneration of the cerebral white matter in severe dementia following head injury. J Neurol Neutrosurg Psychiatry. August 1956;19(3):163-185.
1982	Gennarelli TA, Thibault LE, Adams JH, Graham DI, Thompson CJ, Marcincin RP. Diffuse axonal injury and traumatic coma in the primate. Ann Neurol. 1982;12(6):564-574.

Cited By (21)

Year	Entry
1995	Blumbergs PC, Scott G, Manavis J, Wainwright H, McLean AJ, Kloeden C, Simpson DA. Topography and quantitation of axonal injury as defined by amyloid precursor protein and the sector scoring method in lateral and occipital head impacts: a preliminary report. In: Proceedings of the 1995 International IRCOBI Conference on the Biomechanics of Impact. September 13-15, 1995; Brunnen, Switzerland.199-216.
2001	Zhang L, Yang KH, Dwarampudi R, Omori K, Li T, Chang K, Hardy WN, Khalil TB, King AI. Recent advances in brain injury research: a new human head model development and validation. Stapp Car Crash J. 2001;45:369-394. SAE 2001-22-0017.
1992	Povlishock JT. Traumatically induced axonal injury: pathogenesis and pathobiological implications. Brain Pathol. January 1992;2(1):1-12.
1989	Adams JH, Doyle D, Ford I, Gennarelli TA, Graham DI, McLellan DR. Diffuse axonal injury in head injury: definition, diagnosis and grading. Histopathology. July 1989;15(1):49-59.
2004	Zhang L, Yang KH, King AI. A proposed injury threshold for mild traumatic brain injury. J Biomech Eng. 2004;126(2):226-236.
1989	Gennarelli TA, Thibault LE, Tipperman R, Tomei G, Sergot R, Brown M, Maxwell WL, Graham DI, Adams JH, Irvine A, Gennarelli LM, Duhaime AC, Boock R, Greenberg J. Axonal injury in the optic nerve: a model simulating diffuse axonal injury in the brain. J Neurosurg. August 1989;71(2):244-253.
1988	Lighthall JW. Controlled cortical impact: a new experimental brain injury model. J Neurotrauma. 1988;5(1):1-15.
1995	Povlishock JT, Christman CW. Traumatically induced axonal injury in animals and humans: a review of current thoughts. J Neurotrauma. June 1995;12(3):555-564.
1995	King AI, Ruan JS, Zhou C, Hardy WN, Khalil TB. Recent advances in biomechanics of brain injury research: a review. J Neurotrauma. August 1995;12(4):651-658.
2001	Zhang L, Yang KH, King AI. Comparison of brain responses between frontal and lateral impacts by finite element modeling. J Neurotrauma. 2001;18(1):21-30.
2001	Bain AC, Raghupathi R, Meaney DF. Dynamic stretch correlates to both morphological abnormalities and electrophysiological impairment in a model of traumatic axonal injury. J Neurotrauma. May 2001;18(5):499-511.
1997	Ruan JS, Khalil TB, King AI. Impact head injury analysis using an explicit finite element human head model. J Traffic Med. 1997;25(1-2):33-40.
2001	Zhang L, Yang KH, King AI. Biomechanics of neurotrauma. Neurol Res. March–April 2001;23(2-3):144-156.
2005	Viano DC, Casson IR, Pellman EJ, Zhang L, King AI, Yang KH. Concussion in professional football: brain responses by finite element analysis: part 9. Neurosurgery. November 2005;57(5):891-916.
2012	Garrett JF. Characterization of Blast-Induced Activation of Human Immune Cells [Master's thesis]. Duke University; 2012.
2008	Fijalkowski RJ. Rotational Acceleration Pulse Characteristics Affect Mild Diffuse Brain Injury Severity [PhD thesis]. Marquette University; May 2008.
1998	Bain AC. In Vivo Mechanical Thresholds for Morphological and Functional Axonal Injury [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 1998.
2017	Vascak M. Structural and Functional Alterations in Neocortical Circuits After Mild Traumatic Brain Injury [PhD thesis]. Richmond, VA: Virginia Commonwealth University; April 2017.
1994	Ruan JS. Impact Biomechanics of Head Injury by Mathematical Modeling [PhD thesis]. Detroit, MI: Wayne State University; 1994.
1995	Zhou C. Finite Element Modeling of Impact Response of an Inhomogeneous Brain [PhD thesis]. Detroit, MI: Wayne State University; 1995.
2001	Zhang L. Computational Biomechanics of Traumatic Brain Injury: An Investigation of Head Impact Response and American Football Head Injury [PhD thesis]. Detroit, MI: Wayne State University; May 2001.