1York Trials Unit, Department of Health Sciences, University of York, York, UK
2Chesterfield Hospital, Calow, UK
3Centre for Reviews & Dissemination, University of York, York, UK
4Centre for Haemostasis and Thrombosis, Guy’s and St Thomas’ NHS Trust, London, UK
5Nutritional Sciences Department, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK