Measurement of blast wave by a miniature fiber optic pressure transducer in the rat brain

Chavko, Mikulas; Koller, Wayne A.; Prusaczyk, W. Keith; McCarron, Richard M.

Affiliations

¹Trauma and Resuscitative Medicine Department, Naval Medical Research Center, Silver Spring, MD 20910, United States

Abstract and keywords

Exposure to blast wave that is generated during an explosion may result in brain damage and related neurological impairments. The aim of this study was to investigate pressure changes induced by exposure to blast inside the rat brain. For intracranial pressure measurement we used a miniature optic fiber sensor (o.d. 550 μm) with a computer recording system. The sensor was placed in the third cerebral ventricle of anesthetized rats exposed to 40 kPa blast wave in a pneumatic-pressure driven shock tube. Short pressure waves lasting several ms were detected inside the brain with the magnitude that might result in nervous tissue damage.

Keywords: Explosion; Fiber optic sensor; Rat brain; Trauma

Links

DOI: 10.1016/j.jneumeth.2006.07.018

PubMed: 16949675

WoS: 000243775200011

History

Received: 2006-05-17

Revised: 2006-07-20

Accepted: 2006-07-20

Cited Works (1)

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Cited By (19)

Year	Entry
2012	Merkle AC, Armiger RA, Ott KA, Wickwire AC, Iwaskiw AS, Voo LM, Carneal CM. Characterizing brain mechanics during a two-phase response to dynamic overpressure loading. In: Proceedings of the 40th International Workshop on Human Subjects for Biomechanical Research. 2012.
2012	Wood GW, Panzer MB, Yu AW, Rafaels KA, Matthews KA, Bass CR. Scaling in blast neurotrauma. In: Proceedings of the 40th International Workshop on Human Subjects for Biomechanical Research. 2012.
2013	Wood GW, Panzer MB, Yu AW, Rafaels KA, Matthews KA, Bass CR. Scaling in blast neurotrauma. In: Proceedings of the 2013 International IRCOBI Conference on the Biomechanics of Injury. September 11-13, 2013; Gothenburg, Sweden.549-558.
2016	Rafaels KA, DiLeonardi AM, Bass CR. Understanding the brain injury mechanisms of primary blast exposure. In: Proceedings of the 2016 International IRCOBI Conference on the Biomechanics of Injury. September 14-16, 2016; Malaga, Spain.440-452.
2010	Zhu F, Mao H, Leonardi ADC, Wagner C, Chou C, Jin X, Bir C, VandeVord P, Yang KH, King AI. Development of an FE model of the rat head subjected to air shock loading. Stapp Car Crash J. 2010;54:211-225. SAE 2010-22-0011.
2008	Säljö A, Arrhén F, Bolouri H, Mayorga M, Hamberger A. Neuropathology and pressure in the pig brain resulting from low-impulse noise exposure. J Neurotrauma. December 2008;25(12):1397-1406.
2016	Effgen GB. Improving Outcomes After Repetitive Mild Traumatic Brain Injury from Shock Wave Exposure or Stretch Injury [PhD thesis]. Columbia University; 2016.
2012	Panzer MB. Numerical Simulation of Primary Blast Brain Injury [PhD thesis]. Durham, NC: Duke University; 2012.
2015	Wood GW. Interspecies Scaling in Blast Neurotrauma [PhD thesis]. Duke University; 2015.
2011	Jones CF. Cerebrospinal Fluid Mechanics During and After Experimental Spinal Cord Injury [PhD thesis]. Vancouver, BC: University of British Columbia; June 2011.
2015	Soicher J. Evaluating the Feasibility of Quantifying Spinal Cord Swelling as a Function of Pressure Using Fiber Optic Pressure Sensors [Master's thesis]. Vancouver, BC: University of British Columbia; April 2015.
2010	Rafaels KA. Blast Brain Injury Risk [PhD thesis]. Charlottesville, VA: University of Virginia; December 2010.
2017	Bailey ZS. Epigenetic Mechanisms in Blast-Induced Neurotrauma [PhD thesis]. Virginia Polytechnic Institute and State University; July 17, 2017.
2011	Dal Cengio Leonardi A. An Investigation of the Biomechanical Response from Shock Wave Loading to the Head [PhD thesis]. Detroit, MI: Wayne State University; August 2011.
2011	Sharma S. Biomechanical Analysis of Blast Induced Traumatic Brain Injury: A Finite Element Modeling and Validation Study of Blast Effects on Human Brain [Master's thesis]. Detroit, MI: Wayne State University; August 2011.
2012	Bolander R. A Multi-Species Analysis of Biomechanical Responses of the Head to a Shock Wave [PhD thesis]. Detroit, MI: Wayne State University; May 2012.
2012	Makwana R. Development and Validation of a 3D Finite Element Model of Advanced Combat Helmet and Biomechanical Analysis of Human Head and Helmet Response to Primary Blast Insult [Master's thesis]. Detroit, MI: Wayne State University; May 2012.
2015	Purkait HS. Assessment of Temporal and Spatial Alterations in Spinal Glial Reactivity and the Extent of Cervical Spinal Axonal Injury in the Rat After Blast Overpressure Exposure [Master's thesis]. Detroit, MI: Wayne State University; May 2015.
2017	Feng K. An Investigation of the Mechanism of Traumatic Brain Injury Caused by Blast in the Open Field [PhD thesis]. Detroit, MI: Wayne State University; 2017.