Formulae and tables for the determination of sample sizes and power in clinical trials for testing differences in proportions for the two-sample design:​ a review

Sahai, Hardeo; Khurshid, Anwer

Sahai, Hardeo¹; Khurshid, Anwer²

Formulae and tables for the determination of sample sizes and power in clinical trials for testing differences in proportions for the two-sample design: a review

Stat Med. January 15, 1996;15(1):1-21

Affiliations

¹Department of Biostatistics and Epidemiology, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00936, U.S.A.

¹Department of Mathematical Statistics and Operational Research, University of Exeter, Exeter, EX4 4QE, U.K.
Abstract

This paper is a compendium of exact and asymptotic formulae and tables for estimating the sample size in a clinical trial with two treatment groups and a dichotomous outcome. The paper provides separate formulae for equal and unequal treatment group sizes, formulae for the calculation of power given the sample size, and complete references for all formulae and tables cited.
Links

DOI: 10.1002/(SICI)1097-0258(19960115)15:1<1::AID-SIM134>3.0.CO;2-E

PubMed: 8614740

WoS: A1996TN71100001
History

Received: 1993-02

Revised: 1994-07

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