Cardiopulmonary Resuscitation (CPR) is an exhausting procedure compounded by the difficulties of execution in a moving ambulance. Research was conducted utilizing a cardiopulmonary resuscitation machine vs manual methods of CPR. The CPR machine showed a clear superiority in tests conducted. Recording manikins were used to determine proper hand placement, proper compression rate, compression force and missed beats on all tests. Recordings were made from initial onset of CPR until the patient (manikin) was delivered into the hospital. CPR was started in the floor of a building by manual methods using American Heart Association standards, the manikin was loaded onto a stretcher, was wheeled to the waiting ambulance, loaded into the vehicle, and transported under emergency conditions to a hospital 28.9 kilometers from the starting point. Principal differences in machine vs manual test were nonvarying rate of compression over 21 minute tests, constant compression, stroke depth, no missed beats because of curves, or stops and starts, no incorrect compression placement. In the manual method of CPR over this period the following observations were made: there were 336 incorrect pressure points, 24 missed beats altogether, the rate ranged from 60 to 84 beats per minute and varied periodically from not enough to too much pressure. The machine observations showed a 30 second period of inadequate compression on set up and a 12 second period of inadequate compressions on switchover from portable to fixed oxygen source. It operated consistently at a rate of 54 compressions per minute.