The transportation safety experience for persons using wheelchairs is largely unknown. Motor vehicle crash involvement and injury frequency was examined in a telephone interview completed by 596 wheelchair users. Overall, 42% were drivers. Most subjects also rode as passengers in private vehicles (87%) and public vehicles (61%). Wheelchair use as a seat in the vehicle was higher among passengers than drivers. Crash involvement was highest among drivers and lower in passengers. Reported injuries from non-crash scenarios, though, were higher in passengers compared to drivers. Persons seated in wheelchairs in vehicles appear to be at a greater safety risk.