In a laboratory crash test, the injuries of occupants, such as Head Injure Criterion (HIC), Nij, Combined Thorax Index (CTI) etc., can be obtained and transferred to the Abbreviated Injury Scale (AIS). The calculated AIS value usually represents the severity of injury and can be adopted to evaluate the safety of the test vehicle. However, the AIS cannot reflect the medical resources consumed due to various vehicles of different designs. This study presents a statistical method to estimate injury medical cost from the AIS value of an occupant in a crash test. A frontal impact case study is illustrated. Five steps are carried out as follows: