With the vehicle fleet of family transportation in the United States continuing to evolve primarily through the increasing number of light truck vehicles (LTV), studying the effects of vehicle incompatibility has become increasingly important. Using data collected from a population-based sample of child-involved crashes in insured vehicles, we explored the effect of variations in crash partner vehicle type on child occupant injury risk, stratified by direction of impact. Children in passenger cars and LTVs involved in onside collisions were at an increased risk of serious injury if struck by a LTV as compared to a passenger vehicle (passenger cars and minivans). Though smaller in magnitude, this trend was also present in offside and rear crashes as well.