The particularities of accidents involving large trucks (GVW of 8 tons or larger) in Japan and the future direction of applicable safety measures will be examined herein. An analysis of traffic accidents caused by large trucks according to statistical data has especially revealed the involvement of passenger cars and pedestrians. Accidents involving passenger cars are mostly caused by collisions through carelessness (taking one’s eyes off the road ahead), and can be reduced by using the collision warning system and the forward collision avoidance assistance system. Accidents involving pedestrians often occur while they are crossing roads at night, and can be lessened by the use of night vision or other nighttime visibility aids.