Cartilage thickness mismatches in patellar osteochondral allograft transplants affect local cartilage stresses

Rosario, Ryan<sup>1,2</sup>; Arruda, Ellen M.<sup>1,3,4</sup>; Grant, John A.<sup>5</sup>; Coleman, Rhima M.<sup>1,3</sup>

Affiliations

¹Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, USA

²Department of Mechanical Engineering, Lafayette College, Easton, Pennsylvania, USA

³Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA

⁴Program in Macromolecular Science and Engineering, University of Michigan, Ann Arbor, Michigan, USA

⁵MedSport, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA

Abstract and keywords

Osteochondral allograft implantation is a form of cartilage transplant in which a cylindrical graft of cartilage and subchondral bone from a donor is implanted into a patient's prepared articular defect site. No standard exists for matching the cartilage thickness of the donor and recipient. The goal of this study was to use finite element (FE) analysis to identify the effect of cartilage thickness mismatches between donor and recipient cartilage on cartilage stresses in patellar transplants. Two types of FE models were used: patient-specific 3D models and simplified 2D models. 3D models highlighted which geometric features produced high-stress regions in the patellar cartilage and provided ranges for the parameter sweeps that were conducted with 2D models. 2D models revealed that larger thickness mismatches, thicker recipient cartilage, and a donor-to-recipient cartilage thickness ratio (DRCR) < 1 led to higher stresses at the interface between the donor and recipient cartilage. A surface angle between the donor-recipient cartilage interface and cartilage surface normal near the graft boundary increased stresses when DRCR > 1, with the largest increase observed for an angle of 15°. A surface angle decreased stresses when DRCR < 1. Clinical Significance: This study highlights a potential mechanism to explain the high rates of failure of patellar OCAs. Additionally, the relationship between geometric features and stresses explored in this study led to a hypothetical scoring system that indicates which transplanted patellar grafts may have a higher risk of failure.

Keywords: allograft; bone; cartilage; finite elements; patella

Links

DOI: 10.1002/jor.25569

PubMed: 37031360

WoS: 000974742300001

History

Received: 2022-02-11

Revised: 2023-01-27

Accepted: 2023-03-29

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