Current and emerging technologies for defining and validating tendon cell fate

Huang, Alice H.<sup>1</sup>; Galloway, Jenna L.<sup>2,3</sup>

Affiliations

¹Department of Orthopedic Surgery, Columbia University, New York, New York, USA

²Department of Orthopaedic Surgery, Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

³Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA

Abstract and keywords

The tendon field has been flourishing in recent years with the advent of new tools and model systems. The recent ORS 2022 Tendon Section Conference brought together researchers from diverse disciplines and backgrounds, showcasing studies in biomechanics and tissue engineering to cell and developmental biology and using models from zebrafish and mouse to humans. This perspective aims to summarize progress in tendon research as it pertains to understanding and studying tendon cell fate. The successful integration of new technologies and approaches have the potential to further propel tendon research into a new renaissance of discovery. However, there are also limitations with the current methodologies that are important to consider when tackling research questions. Altogether, we will highlight recent advances and technologies and propose new avenues to explore tendon biology.

Keywords: mouse models; multiomics; sequencing; tendon development; tendon differentiation

Links

DOI: 10.1002/jor.25632

PubMed: 37211925

WoS: 001002616200001

History

Received: 2023-01-13

Revised: 2023-05-09

Accepted: 2023-05-18

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Cited By (1)

Year	Entry
2023	Dyment NA, Kuntz AF, Soslowsky LJ. Special issue: guiding the future of tendon research. J Orthop Res. October 2023;41(10):2081-2081.