This thesis examines the development of a six degrees of freedom finger coordinate system that employs electromagnetic tracking to measure finger kinematics. Secondarily, this thesis validated the in vivo finger coordinate system using a cadaveric study, with bone fixed trackers, as the gold standard. This thesis also compares the proposed method to the clinically used technique of manual goniometry. Lastly, this thesis examines the range of motion of individuals with and without hand arthritis during various activities of daily living, performed with and with joint protection program principles. This study presents a foundation for finger kinematic evaluation for in vivo use and describes a methodology that will be used for larger studies to be conducted to examine finger kinematics in various clinical and functional applications.