Inertial Measurement Units (IMUs) provides embedded and accessible (financially and technically speaking) motion analysis for sports or clinical applications (rehabilitation, therapy…). Despite being advertised for it ease of use, the very nature of IMU sensor makes it prone to errors which are usually corrected through calibration processes thus adding extra complexity for the users. The main goal of this study is to estimate the effect of sensor positioning on the thigh for a simple assessment of squat motion range of motion (ROM) as could be done in a pragmatic clinical approach (i.e., without prior calibration). Kinematics, squat counts and timing of three IMU sensors along the thigh were recorded during squat motion and compared to an optoelectronic reference system. Results showed concordance coefficients of the IMU system over 0.944 without the need for calibration with a preference for placement on the distal part of the segment regarding kinematics data.