Fluid flow in bone in vitro

Johnson, M. W.<sup>1</sup>; Chakkalakal, D. A.<sup>1,2</sup>; Harper, R. A.<sup>1</sup>; Katz, J. L.<sup>1</sup>; Rouhana, S. W.<sup>1</sup>

Affiliations

¹Physics Department and Center for Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12181, U.S.A.

²V. A. Medical Center and University of Nebraska Medical Center, Omaha, NB 68105

Abstract

Recent dielectric measurements suggest that the electromechanical effect in wet (fluid saturated) bone is not due to a piezoelectric effect. This would imply that the electromechanical effect observed in wet bone is due to a streaming potential and is therefore dependent on fluid flow in stressed bone. A model for fluid flow in bone in vitro is presented. This model predicts a rapid decay (of the order of a millisecond or less) for the fluid flow in Haversian systems. The implications of this result for the interpretation of the electromechanical effect in wet bone are discussed.

Links

DOI: 10.1016/0021-9290(82)90054-9

PubMed: 7161290

WoS: A1982PY44000009

History

Received: 1982-06-22

Cited Works (9)

Year	Entry
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Cited By (29)

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1998	Knothe Tate ML, Knothe U, Niederer P. Experimental elucidation of mechanical load-induced fluid flow and its potential role in bone metabolism and functional adaptation. Am J Med Sci. September 1998;316(3):189-195.
1994	Zeng Y, Cowin SC, Weinbaum S. A fiber matrix model for fluid flow and streaming potentials in the canaliculi of an osteon. Ann Biomed Eng. May–June 1994;22(3):280-292.
2002	Qin Y-X, Lin W, Rubin C. The pathway of bone fluid flow as defined by in vivo intramedullary pressure and streaming potential measurements. Ann Biomed Eng. May 2002;30(5):693-702.
1984	Johnson MW. Behavior of fluid in stressed bone and cellular stimulation. Calcif Tiss Int. March 1984;36(suppl 1):S72-S76.
1984	Pollack SR, Petrov N, Salzstein R, Brankov G, Blagoeva R. An anatomical model for streaming potentials in osteons. J Biomech. 1984;17(8):627-636.
1989	Petrov N, Pollack S, Blagoeva R. A discrete model for streaming potentials in a single osteon. J Biomech. 1989;22(6-7):517-521.
1991	Dillaman RM, Roer RD, Gay DM. Fluid movement in bone: theoretical and empirical. J Biomech. 1991;24(suppl 1):163-177.
1994	Weinbaum S, Cowin SC, Zeng Y. A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses. J Biomech. March 1994;27(3):339-360.
1995	Cowin SC, Weinbaum S, Zeng Y. A case for bone canaliculi as the anatomical site of strain generated potentials. J Biomech. November 1995;28(11):1281-1297.
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1987	Li G, Bronk JT, An K-N, Kelly PJ. Permeability of cortical bone of canine tibiae. Microvasc Res. November 1987;34(3):302-310.
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2008	Kwon RY. Mechanical Behavior and Early Molecular Signaling During Mechanotransduction of Fluid Flow in Bone Cells [PhD thesis]. Stanford University; August 2008.
2009	Litzenberger JB. The Role of Integrin Signaling in Bone Mechanotransduction [PhD thesis]. Stanford University; 2009.
1997	Qin Y-X. Fluid Flow, Matrix Strain and Loading Frequency as Interdependent Control Parameters in Skeletal Adaptation [PhD thesis]. Stony Brook, NY: State University of New York at Stony Brook; May 1997.
2007	Isaksson HE. Mechanical and Mechanobiological Influences on Bone Fracture Repair: Identifying Important Cellular Characteristics [PhD thesis]. Eindhoven, The Netherlands: Eindhoven University of Technology; 2007.
2004	LaMothe JM. Functional Adaptation of Bone [PhD thesis]. Calgary, AB: University of Calgary; September 2004.
2000	McCreadie BR. Structural and Material Changes in Osteoporosis: Their Impact on the Mechanical Environment of the Osteocyte [PhD thesis]. University of Michigan; 2000.
1996	Beck BR. The Relationship of Streaming Potential Magnitude to Strain and Periosteal Modeling [PhD thesis]. Eugene, OR: University of Oregon; December 1996.
1996	García AJ. Quantitative Analysis of Fibronectin-Mediated Adhesion of Osteoblast-Like Cells to Bioactive Glass and Hydroxyapatite [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 1996.