Sexual dimorphism in skeletal size, density, and strength

Seeman, Ego<sup>1</sup>

Affiliations

¹Department of Endocrinology and Medicine, Austin and Repatriation Medical Centre, University of Melbourne, 3084 Melbourne, Australia

Links

DOI: 10.1210/jcem.86.10.7960

PubMed: 11600506

WoS: 000171755400002

History

Received: 2001-01-18

Accepted: 2002-05-01

Cited Works (7)

Year	Entry
1983	Parfitt AM, Mathews CH, Villanueva AR, Kleerekoper M, Frame B, Rao DS. Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis: implications for the microanatomic and cellular mechanisms of bone loss. J Clin Invest. October 1983;72(4):1396-1409.
1981	Riggs BL, Wahner HW, Dunn WL, Mazess RB, Offord KP, Melton LJ III. Differential changes in bone mineral density of the appendicular and axial skeleton with aging: relationship to spinal osteoporosis. J Clin Invest. February 1981;67(2):328-335.
1987	Aaron JE, Makins NB, Sagreiya K. The microanatomy of trabecular bone loss in normal aging men and women. Clin Orthop Relat Res. February 1987;215:260-271.
1993	Turner CH, Burr DB. Basic biomechanical measurements of bone: a tutorial. Bone. 1993;14(4):595-608.
1990	Mosekilde L, Mosekilde L. Sex differences in age-related changes in vertebral body size, density and biomechanical competence in normal individuals. Bone. 1990;11(2):67-73.
1988	Ruff CB, Hayes WC. Sex differences in age‐related remodeling of the femur and tibia. J Orthop Res. November 1988;6(6):886-896.
2000	Parfitt AM, Travers R, Rauch F, Glorieux FH. Structural and cellular changes during bone growth in healthy children. Bone. October 2000;27(4):487-494.

Cited By (34)

Year	Entry
2010	Nikander R, Sievänen H, Heinonen A, Daly RM, Uusi-Rasi K, Kannus P. Targeted exercise against osteoporosis: a systematic review and meta-analysis for optimising bone strength throughout life. BMC Med. 2010;8:47.
2006	Sigurdsson G, Aspelund T, Chang M, Jonsdottir B, Sigurdsson S, Eiriksdottir G, Gudmundsson A, Harris TB, Gudnason V, Lang TF. Increasing sex difference in bone strength in old age: the age, gene/environment susceptibility-Reykjavik study (AGES-REYKJAVIK). Bone. September 2006;39(3):644-651.
2020	Galea GL, Delisser PJ, Meakin L, Price JS, Windahl SH. Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice. Bone. April 2020;133:115255.
2020	Oura P, Junno J-A, Autio E, Karppinen J, Niinimäki J. Baseline anthropometric indices predict change in vertebral size in early adulthood: a 10-year follow-up MRI study. Bone. September 2020;138:115506.
2022	Zhang J, Gao R, Jiang Y, Zhang Y, Liu C, Yu F, Zhou W. Novel serological biomarker models composed of bone turnover markers, vitamin D, and estradiol and their auxiliary diagnostic value in girls with idiopathic central precocious puberty. Bone. January 2022;154:116221.
2022	O'Leary TJ, Izard RM, Tang JCY, Fraser WD, Greeves JP. Sex differences in tibial adaptations to arduous training: an observational cohort study. Bone. July 2022;160:116426.
2022	Tuck SP, Hanusch B, Prediger M, Walker JA, McNally R, Datta HK. Reduced trabecular bone mineral density and thinner cortices in men with distal forearm fractures. Bone. November 2022;164:116513.
2023	Whitney DG, Caird MS, Raggio CL, Hurvitz EA, Clines GA, Jepsen KJ. Perspective: a multi-trait integrative approach to understanding the structural basis of bone fragility for pediatric conditions associated with abnormal bone development. Bone. October 2023;175:116855.
2023	Yoon J, Kaya S, Matsumae G, Dole N, Alliston T. M iR181a/b-1 controls osteocyte metabolism and mechanical properties independently of bone morphology. Bone. October 2023;175:116836.
2020	Maupin KA, Dick D, Lee J, Williams BO. Loss of Lgals3 protects against gonadectomy-induced cortical bone loss in mice. Calcif Tiss Int. March 2020;106(3):283-293.
2002	Bass SL, Saxon L, Daly RM, Turner CH, Robling AG, Seeman E, Stuckey S. The effect of mechanical loading on the size and shape of bone in pre-, peri-, and postpubertal girls: a study in tennis players. J Bone Miner Res. December 2002;17(12):2274-2280.
2003	Duan Y, Beck TJ, Wang X-F, Seeman E. Structural and biomechanical basis of sexual dimorphism in femoral neck fragility has its origins in growth and aging. J Bone Miner Res. October 2003;18(10):1766-1774.
2005	Nieves JW, Formica C, Ruffing J, Zion M, Garrett P, Lindsay R, Cosman F. Males have larger skeletal size and bone mass than females, despite comparable body size. J Bone Miner Res. March 2005;20(3):529-535.
2007	Melton LJ III, Riggs BL, Keaveny TM, Achenbach SJ, Hoffmann PF, Camp JJ, Rouleau PA, Bouxsein ML, Amin S, Atkinson EJ, Robb RA, Khosla S. Structural determinants of vertebral fracture risk. J Bone Miner Res. December 2007;22(12):1885-1892.
2010	Wang Q, Wang X-F, Iuliano-Burns S, Ghasem-Zadeh A, Zebaze R, Seeman E. Rapid growth produces transient cortical weakness: a risk factor for metaphyseal fractures during puberty. J Bone Miner Res. July 2010;25(7):1521-1526.
2022	Banica T, Verroken C, T'Sjoen G, Goemaere S, Zmierczak H-G, Fiers T, Kaufman J-M, Lapauw B. Modest changes in sex hormones during early and middle adulthood affect bone mass and size in healthy men: a prospective cohort study. J Bone Miner Res. May 2022;37(5):865-875.
2023	Davey RA. The importance of sex in preclinical studies of bone [published correction appears in J Bone Miner Res. May 2023;38(5):808]. J Bone Miner Res. January 2023;38(1):3-4.
2023	Sharma A, Michels LV, Pitsillides AA, Greeves J, Plotkin LI, Cardo V, Sims NA, Clarkin CE. Sexing bones: improving transparency of sex reporting to address bias within preclinical studies. J Bone Miner Res. January 2023;38(1):5-13.
2008	Melton LJ III, Riggs BL, Leibson CL, Achenbach SJ, Camp JJ, Bouxsein ML, Atkinson EJ, Robb RA, Khosla S. A bone structural basis for fracture risk in diabetes. J Clin Endocrinol Metab. December 2008;03(12):4804-4809.
2019	Saers JPP, Ryan TM, Stock JT. Trabecular bone structure scales allometrically in the foot of four human groups. J Hum Evol. October 2019;135:102654.
2010	Aiyangar AK, Au AG, Crenshaw TD, Ploeg H-L. Recovery of bone strength in young pigs from an induced short-term dietary calcium deficit followed by a calcium replete diet. Med Eng Phys. December 2010;32(10):1116-1123.
2020	Stuck AK, Schenk D, Zysset P, Bütikofer L, Mathis A, Lippuner K. Reference values and clinical predictors of bone strength for HR-pQCT-based distal radius and tibia strength assessments in women and men. Osteoporos Int. October 2020;31(10):1913-1923.
2020	Lin C. Effects of Marathon Training on Male and Female Femoral Stress Fracture Risk [Master's thesis]. California Polytechnic State University; November 2020.
2017	Saers JPP. Ontogeny and Functional Adaptation of Trabecular Bone in the Human Foot [PhD thesis]. Cambridge, UK: University of Cambridge; July 2017.
2016	Oei L. Epidemiological, Radiological and Genetic Aspects of Endocrine Bone Diseases [PhD thesis]. Erasmus University Rotterdam; December 14, 2016.
2007	Schneider P. Ultrastructural Phenotyping of Murine Bone Using Synchrotron Micro- and Nano-Computed Tomography [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2007.
2008	Weeks BK. Improving Bone Health With Physical Activity: The Power PE Study and Development of the Bone-Specific Physical Activity Questionnaire (BPAQ) [PhD thesis]. Brisbane, Australia: Griffith University; January 2008.
2006	Macdonald HM. Effectiveness of a School-Based Physical Activity Intervention for Increasing Bone Strength in Children: Action Schools! British Columbia [PhD thesis]. Vancouver, BC: University of British Columbia; July 2006.
2015	Tan VPS. Effects of a School-Based Physical Activity Intervention on Adolescent Bone Strength, Structure and Density: The Health Promoting Secondary Schools (HPSS) Bone Health Study [PhD thesis]. Vancouver, BC: University of British Columbia; June 2015.
2017	Gabel LEC. Bone Strength Accrual Across Adolescent Growth and the Influences of Physical Activity and Sedentary Time [PhD thesis]. Vancouver, BC: University of British Columbia; April 2017.
2018	George JK. Using Finite Element Models Under Multiple Loading Conditions to Improve the Association Between Radius and Tibia Microarchitecture and Prevalent Osteoporotic Vertebral Fracture [Master's thesis]. Calgary, AB: University of Calgary; May 2018.
2022	Blank MA. Defining Mechanisms by Which EphrinB2 in Osteocytes Controls Bone Strength and Material Quality [PhD thesis]. University of Melbourne; September 2022.
2013	Eleazer CD. The Interaction of Mechanical Loading and Metabolic Stress on Human Cortical Bone: Testing Anthropological Assumptions Using Cross-Sectional Geometry and Histomorphology [PhD thesis]. Knoxville, University of Tennessee; August 2013.
2015	Ng AH-M. A Mouse Model of Adynamic Bone Disease (ABD) and Its Consequences on Bone Quality With Age [PhD thesis]. University of Toronto; 2015.