Mechanisms of bone resorption

Everts, Vincent; Jansen, Ineke D. C.; de Vries, Teun J.

Affiliations

¹Department of Oral Cell Biology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, the Netherlands

²Department of Anatomy, Dental Faculty, Chulalongkorn University, Bangkok, Thailand

³Department of Periodontology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, the Netherlands

Abstract and keywords

Resorption of mineralized tissues like bone is accomplished by a unique cell type: the osteoclast. This multinucleated cell has the capacity to dissolve the mineral by lowering the pH. Subsequently, the release of certain proteolytic enzymes, in particular cathepsin K, results in the digestion of the organic matrix mainly consisting of collagen. In this short review we will describe the unique features of the osteoclast making it possible for the cell to resorb mineralized tissues.

Keywords: Osteoclast; Resorption; Osteoclast heterogeneity; Demineralization; Protein degradation

Links

DOI: 10.1016/j.bone.2022.116499

PubMed: 35872106

WoS: 000849838700001

History

Received: 2022-05-21

Revised: 2022-07-12

Accepted: 2022-07-15

Online: 2022-07-21

Cited Works (7)

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