What role does the osteocyte network play in bone adaptation?

Turner, C. H.<sup>1</sup>; Forwood, M. R.<sup>2</sup>

Affiliations

¹Biomechanics and Biomaterials Research Center, Indiana University Medical Center, Indianapolis, IN, USA

²Department of Anatomical Sciences, The University of Queensland, Brisbane, Queensland, Australia

Links

DOI: 10.1016/8756-3282(94)00052-2

PubMed: 7786630

WoS: A1995RB63800001

History

Received: 1994-08-12

Revised: 1994-10-05

Accepted: 1994-12-1

Cited Works (18)

Year	Entry
1990	Palumbo C, Palazzini S, Marotti G. Morphological study of intercellular junctions during osteocyte differentiation. Bone. 1990;11(6):401-406.
1993	Lanyon LE. Osteocytes, strain detection, bone modeling and remodeling. Calcif Tiss Int. February 1993;53(suppl 1):S102-S107.
1993	Harrigan TP, Hamilton JJ. Bone strain sensation via transmembrane potential changes in surface osteoblasts: loading rate and microstructural implications. J Biomech. February 1993;26(2):183-200.
1984	Menton DN, Simmons DJ, Chang S-L, Orr BY. From bone lining cell to osteocyte: an SEM study. Anat Rec. May 1984;209(1):29-39.
1993	Dallas SL, Zaman G, Pead MJ, Lanyon LE. Early strain-related changes in cultured embryonic chick tibiotarsi parallel those associated with adaptive modeling in vivo. J Bone Miner Res. March 1993;8(3):251-259.
1989	Skerry TM, Bitensky L, Chayen J, Lanyon LE. Early strain‐related changes in enzyme activity in osteocytes following bone loading in vivo. J Bone Miner Res. October 1989;4(5):783-788.
1985	Burr DB, Martin RB, Schaffler MB, Radin EL. Bone remodeling in response to in vivo fatigue microdamage. J Biomech. 1985;18(3):189-200.
1991	Dillaman RM, Roer RD, Gay DM. Fluid movement in bone: theoretical and empirical. J Biomech. 1991;24(suppl 1):163-177.
1992	van der Plas A, Nijweide PJ. Isolation and purification of osteocytes. J Bone Miner Res. April 1992;7(4):389-396.
1991	Rawlinson SCF, El‐Haj AJ, Minter SL, Tavares IA, Bennett A, Lanyon LE. Loading‐related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: a role for prostacyclin in adaptive bone remodeling? J Bone Miner Res. December 1991;6(12):1345-1351.
1994	Turner CH, Forwood MR, Rho J, Yoshikawa T. Mechanical loading thresholds for lamellar and woven bone formation. J Bone Miner Res. January 1994;9(1):87-97.
1988	Pead MJ, Suswillo R, Skerry TM, Vedi S, Lanyon LE. Increased ³H-uridine levels in osteocytes following a single short period of dynamic bone loadingin vivo. Calcif Tiss Int. August 1988;43(2):92-96.
1984	Rubin CT, Lanyon LE. Regulation of bone formation by applied dynamic loads. J Bone Joint Surg. March 1984;66A(3):397-402.
1994	Weinbaum S, Cowin SC, Zeng Y. A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses. J Biomech. March 1994;27(3):339-360.
1994	Turner CH, Forwood MR, Otter MW. Mechanotransduction in bone: do bone cells act as sensors of fluid flow? FASEB J. August 1994;8(11):875-878.
1990	El Haj AJ, Minter SL, Rawlinson SCF, Suswillo R, Lanyon LE. Cellular responses to mechanical loading in vitro. J Bone Miner Res. September 1990;5(9):923-932.
1993	Mori S, Burr DB. Increased intracortical remodeling following fatigue damage. Bone. March–April 1993;14(2):103-109.
1994	Aarden EM, Burger EH, Nijweide PJ. Function of osteocytes in bone. J Cell Biochem. July 1994;55(3):287-299.

Cited By (17)

Year	Entry
1996	Forwood MR, Owan I, Takano Y, Turner CH. Increased bone formation in rat tibiae after a single short period of dynamic loading in vivo. Am J Physiol Endocrinol Metab. March 1996;270(3):E419-E423.
2015	Buenzli PR, Sims NA. Quantifying the osteocyte network in the human skeleton. Bone. June 2015;75:144-150.
1995	Duncan RL, Turner CH. Mechanotransduction and the functional response of bone to mechanical strain. Calcif Tiss Int. December 1995;57(5):344-358.
2020	Milovanovic P, Busse B. Phenomenon of osteocyte lacunar mineralization: indicator of former osteocyte death and a novel marker of impaired bone quality? Endocr Connect. April 2020;9(4):R70-R80.
2001	Cheng B, Zhao S, Luo J, Sprague E, Bonewald LF, Jiang JX. Expression of functional gap junctions and regulation by fluid flow in osteocyte-like MLO-Y4 cells. J Bone Miner Res. February 2001;16(2):249-259.
2008	Tommasini SM. Phenotypic Integration Contributes to Skeletal Functionality and Fragility [PhD thesis]. New York, NY: The City University of New York; 2008.
1998	Robling AG. Histomorphometric Assessment of Mechanical Loading History from Human Skeletal Remains: The Relation Between Micromorphology and Macromorphology At the Femoral Midshaft [PhD thesis]. University of Missouri; December 1998.
2015	Spatz JM. The Role of Osteocytes in Disuse and Microgravity-Induces Bone Loss [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; September 2015.
2008	Price C. Systems Based Approaches to Identifying How Genetically Varying Skeletal Growth Affects Skeletal Functionality and Fragility [PhD thesis]. Mount Sinai School of Medicine; 2008.
1997	Qin Y-X. Fluid Flow, Matrix Strain and Loading Frequency as Interdependent Control Parameters in Skeletal Adaptation [PhD thesis]. Stony Brook, NY: State University of New York at Stony Brook; May 1997.
1999	Judex S. The Effect of Exercise-Induced Mechanical Stimuli on Cortical Bone [PhD thesis]. Calgary, AB: University of Calgary; 1999.
1996	Adams DJ. Mechanical Factors Initiating Appositional Bone Formation [PhD thesis]. University of Iowa; May 1996.
2006	Blouin S. Modèles animaux de perte osseuse bénigne et maligne utilisable pour l'évaluation de biomatériaux [Animal Models of Benign and Malignant Bone Loss Usable in Biomaterial Studies] [PhD thesis]. Université d'Angers; 2006.
1996	Beck BR. The Relationship of Streaming Potential Magnitude to Strain and Periosteal Modeling [PhD thesis]. Eugene, OR: University of Oregon; December 1996.
2002	Wang M-Y. Quantifying Musculoskeletal Load and Adaptation: Biomechanical Consideration [PhD thesis]. University of Southern California (USC); August 2002.
2016	Andronowski JM. Evaluating Differential Nuclear DNA Yield Rates Among Human Bone Tissue Types: A Synchrotron Micro-CT Approach [PhD thesis]. Knoxville, University of Tennessee; May 2016.
2009	Rath AL. The Effects of Strain and Perilacunar Environment on the Mechanotransduction of Osteocytes [PhD thesis]. Winston-Salem, NC: Wake Forest University; May 2009.