Mechanobiological Investigation of Periosteum Through Finite Element Modeling and Histology

A single stage bone-transport procedure has been shown effective in bridging critical sized diaphyseal bone defects. The procedure harnesses the regenerative potential of the periosteum to infill defects fully with woven bone within two weeks of surgery. In this study, we aim to elucidate the dynamic micromechanical environment of the defect zone. We developed a displacement-driven FE model of the defect, periosteum, and interlocked intramedullary nail in situ, to predict strains and fluid flow within the defect. We hypothesized that areas of greatest mechanically-modulated transport in the defect have significant effects on patterns of de novo bone generation throughout the defect. The FE model was validated using optical strain measurements. This model serves as a preliminary feasibility study for future models to more accurately predict strain, fluid flow, and mass transport within the defect for the study of physical and chemical effects on de novo tissue building by stem cells.

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Year

Entry

1982

Armstrong CG, Mow VC. Variations in the intrinsic mechanical properties of human articular cartilage with age, degeneration, and water content. J Bone Joint Surg. 1982;64A(1):88-94.

1988

Schaffler MB, Burr DB. Stiffness of compact bone: effects of porosity and density. J Biomech. 1988;21(1):13-16.

2008

MacNeil JA, Boyd SK. Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element method. Bone. June 2008;42(6):1203-1213.

1941

Biot MA. General theory of three‐dimensional consolidation. J Appl Phys. February 1941;12(2):155-164.

2003

Steck R, Niederer P, Knothe Tate ML. A finite element analysis for the prediction of load-induced fluid flow and mechanochemical transduction in bone. J Theo Biol. January 21, 2003;220(2):249-259.