Fluorometric assay of DNA in cartilage explants using Hoechst 33258

Kim, Young-Jo<sup>1</sup>; Sah, Robert L. Y.<sup>1</sup>; Doong, Joe-Yuan H.<sup>1</sup>; Grodzinsky, Alan J.<sup>1</sup>

Year	Entry
1996	Schinagl RM, Ting MK, Price JH, Sah RL. Video microscopy to quantitate the inhomogeneous equilibrium strain within articular cartilage during confined compression. Ann Biomed Eng. July–August 1996;24(4):500-512.
2002	Mauck RL, Seyhan SL, Ateshian GA, Hung CT. Influence of seeding density and dynamic deformational loading on the developing structure/function relationships of chondrocyte-seeded agarose hydrogels. Ann Biomed Eng. September 2002;30(8):1046-1056.
2004	Hung CT, Mauck RL, Wang CC-B, Lima EG, Ateshian GA. A paradigm for functional tissue engineering of articular cartilage via applied physiologic deformational loading. Ann Biomed Eng. January 2004;32(1):35-49.
1991	Sah RL-Y, Doong J-YH, Grodzinsky AJ, Plaas AHK, Sandy JD. Effects of compression on the loss of newly synthesized proteoglycans and proteins from cartilage explants. Arch Biochem Biophys. April 1991;286(1):209-29.
1993	Parkkinen JJ, Ikonen J, Lammi MJ, Laakkonen J, Tammi M, Helminen HJ. Effects of cyclic hydrostatic pressure on proteoglycan synthesis in cultured chondrocytes and articular cartilage explants. Arch Biochem Biophys. January 1993;300(1):458-465.
1994	Sah RL, Chen AC, Grodzinsky AJ, Trippel SB. Differential effects of bFGF and IGF-I on matrix metabolism in calf and adult bovine cartilage explants. Arch Biochem Biophys. January 1994;308(1):137-147.
1994	Kim Y-J, Sah RLY, Grodzinsky AJ, Plaas AHK, Sandy JD. Mechanical regulation of cartilage biosynthetic behavior: physical stimuli. Arch Biochem Biophys. May 1994;311(1):1-12.
1996	Kim Y-J, Grodzinsky AJ, Plaas AHK. Compression of cartilage results in differential effects on biosynthetic pathways for aggrecan, link protein, and hyaluronan. Arch Biochem Biophys. April 15, 1996;328(2):331-340.
2000	Bonassar LJ, Grodzinsky AJ, Srinivasan A, Davila SG, Trippel SB. Mechanical and physicochemical regulation of the action of insulin-like growth factor-I on articular cartilage. Arch Biochem Biophys. July 1, 2000;379(1):57-63.
2000	Ragan PM, Chin VI, Hung H-HK, Masuda K, Thonar EJ-MA, Arner EC, Grodzinsky AJ, Sandy JD. Chondrocyte extracellular matrix synthesis and turnover are influenced by static compression in a new alginate disk culture system. Arch Biochem Biophys. November 15, 2000;383(2):256-264.
2001	Jin M, Frank EH, Quinn TM, Hunziker EB, Grodzinsky AJ. Tissue shear deformation stimulates proteoglycan and protein biosynthesis in bovine cartilage explants. Arch Biochem Biophys. November 1, 2001;395(1):41-48.
2007	Asanbaeva A, Masuda K, Thonar EJ-MA, Klisch SM, Sah RL. Mechanisms of cartilage growth: modulation of balance between proteoglycan and collagen in vitro using chondroitinase ABC. Arthritis Rheum. January 2007;56(1):188-198.
2001	Gooch KJ, Blunk T, Courter DL, Sieminski AL, Bursac PM, Vunjak-Novakovic G, Freed LE. IGF-I and mechanical environment interact to modulate engineered cartilage development. Biochem Biophys Res Commun. September 7, 2001;286(5):909-915.
2005	Burdick JA, Chung C, Jia X, Randolph MA, Langer R. Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks. Biomacromolecules. January–February 2005;6(1):386-391.
2002	Hunter CJ, Imler SM, Malaviya P, Nerem RM, Levenston ME. Mechanical compression alters gene expression and extracellular matrix synthesis by chondrocytes cultured in collagen I gels. Biomaterials. February 15, 2002;23(4):1249-1259.
1999	Carver SE, Heath CA. Increasing extracellular matrix production in regenerating cartilage with intermittent physiological pressure. Biotechnol Bioeng. 1999;62(2):166-174.
1998	Vunjak-Novakovic G, Obradovic B, Martin I, Bursac PM, Langer R, Freed LE. Dynamic cell seeding of polymer scaffolds for cartilage tissue engineering. Biotechnol Prog. March–April 1998;14(2):193-202.
2000	Pazzano D, Mercier KA, Moran JM, Fong SS, DiBiasio DD, Rulfs JX, Kohles SS, Bonassar LJ. Comparison of chondrogensis in static and perfused bioreactor culture. Biotechnol Prog. September–October 2000;16(5):893-896.
1998	Freed LE, Hollander AP, Martin I, Barry JR, Langer R, Vunjak-Novakovic G. Chondrogenesis in a cell-polymer-bioreactor system. Exp Cell Res. April 10, 1998;240(1):58-65.
2004	Kisiday JD, Jin M, DiMicco MA, Kurz B, Grodzinsky AJ. Effects of dynamic compressive loading on chondrocyte biosynthesis in self-assembling peptide scaffolds. J Biomech. May 2004;37(5):595-604.
2004	Vanderploeg EJ, Imler SM, Brodkin KR, Garcı́a AJ, Levenston ME. Oscillatory tension differentially modulates matrix metabolism and cytoskeletal organization in chondrocytes and fibrochondrocytes. J Biomech. December 2004;37(12):1941-1952.
2006	Kelly T-AN, Ng KW, Wang CC-B, Ateshian GA, Hung CT. Spatial and temporal development of chondrocyte-seeded agarose constructs in free-swelling and dynamically loaded cultures. J Biomech. 2006;39(8):1489-1497.
1993	Freed LE, Marquis JC, Nohria A, Emmanual J, Mikos AG, Langer R. Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers. J Biomed Mater Res. January 1993;27(1):11-23.
2003	Waldman SD, Spiteri CG, Grynpas MD, Pilliar RM, Hong J, Kandel RA. Effect of biomechanical conditioning on cartilaginous tissue formation in vitro. J Bone Joint Surg. 2003;85A(suppl 2):101-105.
1993	Urban JPG, Hall AC, Gehl KA. Regulation of matrix synthesis rates by the ionic and osmotic environment of articular chondrocytes. J Cell Physiol. February 1993;154(2):262-270.
1995	Buschmann MD, Gluzband YA, Grodzinsky AJ, Hunziker EB. Mechanical compression modulates matrix biosynthesis in chondrocyte/agarose culture. J Cell Sci. April 1995;108(4):1497-1508.
2005	Jadin KD, Wong BL, Bae WC, Li KW, Williamson AK, Schumacher BL, Price JH, Sah RL. Depth-varying density and organization of chondrocytes in immature and mature bovine articular cartilage assessed by 3D imaging and analysis. J Histochem Cytochem. September 2005;53(9):1109-1119.
1989	Sah RL-Y, Kim Y-J, Doong J-YH, Grodzinsky AJ, Plass AHK, Sandy JD. Biosynthetic response of cartilage explants to dynamic compression. J Orthop Res. 1989;7(5):619-636.
1992	Buschmann MD, Gluzband YA, Grodzinsky AJ, Kimura JH, Hunziker EB. Chondrocytes in agarose culture synthesize a mechanically functional extracellular matrix. J Orthop Res. November 1992;10(6):745-758.
1995	Reindel ES, Ayroso AM, Chen AC, Chun DM, Schinagl RM, Sah RL. Integrative repair of articular cartilage in vitro: adhesive strength of the interface region. J Orthop Res. September 1995;13(5):751-760.
1995	Smith RL, Donlon BS, Gupta MK, Mohtai M, Das P, Carter DR, Cooke J, Gibbons G, Hutchinson N, Schurman DJ. Effects of fluid-induced shear on articular chondrocyte morphology and metabolism in vitro. J Orthop Res. November 1995;13(6):824-831.
1996	Smith RL, Rusk SF, Ellison BE, Wessells P, Tsuchiya K, Carter DR, Caler WE, Sandell LJ, Schurman DJ. In vitro stimulation of articular chondrocyte mRNA and extracellular matrix synthesis by hydrostatic pressure. J Orthop Res. 1996;14(1):53-60.
1999	Vunjak-Novakovic G, Martin I, Obradovic B, Treppo S, Grodzinsky AJ, Langer R, Freed LE. Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue-engineered cartilage. J Orthop Res. January 1999;17(1):130-138.
1999	Ragan PM, Badger AM, Cook M, Chin VI, Gowen M, Grodzinsky AJ, Lark MW. Down-regulation of chondrocyte aggrecan and type-II collagen gene expression correlates with increases in static compression magnitude and duration. J Orthop Res. November 1999;17(6):836-842.
2001	Bonassar LJ, Grodzinsky AJ, Frank EH, Davila SG, Bhaktav NR, Trippel SB. The effect of dynamic compression on the response of articular cartilage to insulin-like growth factor-i. J Orthop Res. January 2001;19(1):11-17.
2001	Chen C-T, Burton-Wurster N, Borden C, Hueffer K, Bloom SE, Lust G. Chondrocyte necrosis and apoptosis in impact damaged articular cartilage. J Orthop Res. July 2001;19(4):703-711.
2001	Obradovic B, Martin I, Padera RF, Treppo S, Freed LE, Vunjak-Navakovic G. Integration of engineered cartilage. J Orthop Res. November 2001;19(6):1089-1097.
2002	Davisson T, Kunig S, Chen A, Sah R, Ratcliffe A. Static and dynamic compression modulate matrix metabolism in tissue engineered cartilage. J Orthop Res. July 2002;20(4):842-848.
2003	Masuda K, Sah RL, Hejna MJ, Thonar EJ-MA. A novel two-step method for the formation of tissue-engineered cartilage by mature bovine chondrocytes: the alginate-recovered-chondrocyte (ARC) method. J Orthop Res. January 2003;21(1):139-148.
2003	Angele P, Yoo JU, Smith C, Mansour J, Jepsen KJ, Nerlich M, Johnstone B. Cyclic hydrostatic pressure enhances the chondrogenic phenotype of human mesenchymal progenitor cells differentiated in vitro. J Orthop Res. May 2003;21(3):451-457.
2003	Williamson AK, Chen AC, Masuda K, Thonar EJ, Sah RL. Tensile mechanical properties of bovine articular cartilage: variations with growth and relationships to collagen network components. J Orthop Res. September 2003;21(5):872-880.
2022	Salzer E, Mouser VHM, Tryfonidou MA, Ito K. A bovine nucleus pulposus explant culture model. J Orthop Res. September 2022;40(9):2089-2102.
1997	Freed LE, Langer R, Martin I, Pellis NR, Vunjak-Novakovic G. Tissue engineering of cartilage in space. Proc Natl Acad Sci USA. December 9, 1997;94(25):13885-13890.
2004	Huang CC, Hagar KL, Frost LE, Sun Y, Cheung HS. Effects of cyclic compressive loading on chondrogenesis of rabbit bone-marrow derived mesenchymal stem cells. Stem Cells. May 2004;22(3):313-323.
2004	Almarza AJ, Athanasiou KA. Seeding techniques and scaffolding choice for tissue engineering of the temporomandibular joint disk. Tissue Eng. November 2004;10(11-12):1787-1795.
2006	Gemmiti CV, Guldberg RE. Fluid flow increases type II collagen deposition and tensile mechanical properties in bioreactor-grown tissue-engineered cartilage. Tissue Eng. March 2006;12(3):469-479.
2001	Bursac N. Engineered Cardiac Tissue: A Novel in Vitro Model for Electrophysiological Studies of Cardiac Muscle [PhD thesis]. Boston University; 2001.
2015	Whitney GA. Characterization of the Frictional-Shear Damage Properties of Scaffold-Free Engineered Cartilage and Reduction of Damage Susceptibility by Upregulation of Collagen Content [PhD thesis]. Cleveland, OH: Case Western Reserve University; January 2015.
2017	Tangtrongsup S. Effects of Dexamethasone and Oxidative Environment on Chondrogenesis of Bone Marrow-Derived Mesenchymal Stem Cells [PhD thesis]. Colorado State University; 2017.
2003	Mauck RL. Functional Tissue Engineering of Articular Cartilage: The Effect of Physical Forces on the in Vitro Growth of Engineered Constructs [PhD thesis]. Columbia University; 2003.
2006	Kelly T-AN. Functional Tissue Engineering of Articular Cartilage: Characterization and Optimization of Chondrocyte-Seeded Agarose Hydrogels [PhD thesis]. Columbia University; 2006.
2007	Jiang J. The Role of Cellular Interactions in Osteochondral Graft Design and the Maintenance of a Stable Osteochondral Interface [PhD thesis]. Columbia University; 2007.
2016	Boushell MK. Scaffold Design and Optimization for Integrative Cartilage Repair [PhD thesis]. Columbia University; 2016.
2020	Mosher CZ. Interface Scaffold Design Principles for Integrative Cartilage Regeneration [PhD thesis]. Columbia University; 2020.
2006	Roy R. Non-Enzymatic Glycation for the Processing of Type I Collagen Gels for Cartilage Tissue Engineering [PhD thesis]. Ithaca, NY: Cornell University; January 2006.
2010	Babalola OM. Effects of Physical Stimuli on Extracellular Matrix Assembly by Chondrocytes and Mesenchymal Stem Cells: Experimental and Finite Element Analyses [PhD thesis]. Ithaca, NY: Cornell University; May 2010.
2010	Ballyns JJ. Dynamic Loading of Anatomically Shaped Meniscal Constructs Generated Via MRI and Micro-CT Imaging [PhD thesis]. Ithaca, NY: Cornell University; August 2010.
2014	Puetzer JL. Development of Engineered Menisci With Native-Like Organization Using High Density Collagen Gels and Mechanical Stimulation [PhD thesis]. Ithaca, NY: Cornell University; August 2014.
2017	McCorry MC. Tissue Engineering the Meniscus for Clinical Translation: Stem Cells, Fibers, and Attachments [PhD thesis]. Ithaca, NY: Cornell University; August 2017.
2018	Cohen BP. Overcoming Clinical Challenges to Tissue Engineering the Human Auricle [PhD thesis]. Ithaca, NY: Cornell University; December 2018.
2019	Diamantides NC. Development of Collagen Bioinks for Cartilage Bioprinting [PhD thesis]. Ithaca, NY: Cornell University; December 2019.
2019	Middendorf JM. Establishing New Standards for Cartilage Repair: The Structure-Function Relationship of Human Tissue Engineered Cartilage [PhD thesis]. Ithaca, NY: Cornell University; June 2019.
2021	Lintz M. Tissue Engineering Strategies for Total Disc Replacement: Structure and Mechanical Function of the Intervertebral Disc [PhD thesis]. Ithaca, NY: Cornell University; August 2021.
2007	Nettles DL. Artificial Neural Network Modeling of Crosslinked Elastin -Like Polypeptide Formulations Parameters Effects on Physical Properties and Cellular Interactions for Cartilage Tissue Engineering [PhD thesis]. Duke University; 2007.
2012	Diekman BO. Stem Cell-Based Strategies to Study, Prevent, and Treat Cartilage Injury and Osteoarthritis [PhD thesis]. Duke University; 2012.
2001	Hunter CJ. Mechanical Stimulation of an in Vitro Articular Cartilage Defect Repair Model [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; October 2001.
2005	Case ND. Oscillatory Compressive Loading Effects on Mesenchymal Progenitor Cells Undergoing Chondrogenic Differentiation in Hydrogel Suspension [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; May 2005.
2005	Imler SM. In Vitro Modulation of Meniscus Biosynthesis: A Basis for Understanding Cellular Response to Physiologically Relevant Stimuli [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2005.
2006	Gemmiti CV. Effect of Fluid Flow on Tissue-Engineered Cartilage in a Novel Bioreactor [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2006.
2006	Vanderploeg EJ. Mechanotransduction in Engineered Cartilaginous Tissues: In Vitro Oscillatory Tensile Loading [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2006.
2007	Coleman R. Development of a Small Animal Model to Study Tissue Engineering Strategies for Growth Plate Defects [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2007.
2007	Connelly JT. Regulatory Mechanisms in the Chondrogenesis of Mesenchymal Progenitors: The Roles of Cyclic Tensile Loading and Cell-Matrix Interactions [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2007.
2007	Wilson CG. Mechanisms and Functional Implications of Aggrecan Catabolism in Cartilage and Meniscal Fibrocartilage [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; May 2007.
1990	Sah RL-Y. Biophysical Regulation of Matrix Systhesis, Assembly, and Degradation in Dynamically Compressed Calf Cartilage [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; 1990.
1995	Bonassar LJ. Matrix Metalloproteinase Activity and Inhibition in Articular Cartilage: Effects on Composition and Biophysical Properties and Relevance to Osteoarthritis [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; February 1995.
1996	Quinn TM. Articular Cartilage: Matrix Assembly, Mediation of Chondrocyte Metabolism, and Response to Compression [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; May 1996.
1999	Ragan PM. The Effect of Mechanical Compression on Chondrocyte Gene Expression [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; May 1999.
1999	Treppo S. Physical Diagnostics of Cartilage Degeneration [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; February 1999.
2002	Jin M. Chondrocyte Metabolism and Matrix Nano-Electromechanics: The Response to Cartilage Tissue Shear Deformation Cambridge, MA: Massachusetts Institute of Technology; February 2002.
2002	Lee CR. Behavior of Passaged Chondrocytes in Collagen-Glycosaminoglycan Scaffolds: Effects of Cross-Linking, Mechanical Loading, and Genetic Modification of the Scaffold [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; February 2002.
2003	Kisiday JD. In Vitro Culture of a Chondrocyte-Seeded Peptide Hydrogel and the Effects of Dynamic Compression [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2003.
2008	Chai DH. Progression of Chondrocyte Signaling Responses to Mechanical Stimulation in 3-D Gel Culture [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; February 2008.
2009	Kopesky PW. Self-Assembling Peptide Hydrogels Promote in Vitro Chondrogenesis of Bone Marrow-Derived Stromal Cells: Effects of Peptide Sequence, Cell Donor Age, and Method of Growth Factor Delivery [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2009.
2010	Lee H-Y. Ultrastructure and Nanomechanical Properties of Aggrecan from Native Cartilage and Engineered Tissue [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2010.
2010	Miller RE. In Vitro and in Vivo Growth Factor Delivery to Chondrocytes and Bone-Marrow-Derived Stromal Cells in Cartilage and in Self-Assembling Peptide Scaffolds [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2010.
2012	Florine EM. Optimizing Chondrogenic Factors and Protein Delivery Methods for Cartilage Repair [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2012.
2013	Li Y. In Vitro Model of Injury/cytokine-Induced Cartilage Catabolism Modulated by Dynamic Compression, Growth Factors, and Glucocorticoids [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2013.
2016	Liebesny PH. Single-Dose Growth Factor Treatments to Enhance Cell Recruitment and Neotissue Integration in an Augmented Microfracture Cartilage Repair Model [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2016.
2016	Wang Y. Molecular Pathway Analysis and Therapeutics Development in Post-Traumatic Osteoarthritis [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; September 2016.
2020	Krishnan Y. Intra/extracellular Multi-Drug Delivery for Osteoarthritis [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; September 2020.
2014	Steward AJ. The Mechanotransduction of Hydrostatic Pressure by Mesenchymal Stem Cells [PhD thesis]. University of Notre Dame; April 2014.
2019	McDermott AM. Mechanical Regulation of Progenitor Cell Differentiation During Endochondral Ossification [PhD thesis]. Notre Dame, IN: University of Notre Dame; July 2019.
2017	Sim S. Développement d'une base de données cartographiques et de modèles statistiques pour la caractérisation du cartilage articulaire [PhD thesis]. École polytechnique de Montréal; May 2017.
2009	Fan CY. Effects of Intermittent Static and Dynamic Tension on Articular Chondrocytes in High Density Culture [Master's thesis]. Queen's University; March 2009.
2009	McGregor AJ. A Method to Improve Cartilage Integration [Master's thesis]. Queen's University; December 2009.
2010	Usprech JF. A Therapeutic Dose of Adenosine Triphosphate (ATP) for Cartilage Tissue Engineering [Master's thesis]. Queen's University; September 2010.
2011	Bow JK. Using Adenosine Triphosphate (ATP) as a Substitute for Mechanical Stimulation for Tissue Engineering Applications [Master's thesis]. Queen's University; January 2011.
2011	Surrao DC. Biomimetic Scaffolds for Ligament Tissue Engineering [PhD thesis]. Queen's University; December 2011.
2012	Brenner JM. Development and Validation of Large-Sized Engineered Cartilage Constructs in Full –thickness Chondral Defects in a Rabbit Model [Master's thesis]. Queen's University; January 2012.
2012	Kaupp JA. Simulated Joint Loading Enhances the Expression of of Superficial Zone Markers in Tissue Engineered Cartilage Constructs [PhD thesis]. Queen's University; February 2012.
2012	Khan AA. Effects of Additional Sodium Bicarbonate on Extra/intra Cellular Factors in a Continuous Flow Bioreactor for the Production of Tissue Engineered Articular Cartilage [PhD thesis]. Queen's University; October 2012.
2014	Hayami JWS. Load Bearing Regenerative Repairs for the Cartilaginous Soft Tissue of the Intervertebral Disc [PhD thesis]. Queen's University; August 2014.
2015	Bartnikowski M. Design and Characterisation of Scaffolds for Osteochondral Regeneration [PhD thesis]. Queensland University of Technology; December 2015.
2005	Almarza AJ. Extracellular Matrix Characterization and Tissue Engineering of the Temporomandibular Joint Disc [PhD thesis]. Houston, TX: Rice University; April 2005.
2005	Hu J. Chondrocyte Self -Assembly and Culture in Bioreactors [PhD thesis]. Houston, TX: Rice University; April 2005.
2008	Johns DE. Functional Tissue Engineering of the Temporomandibular Joint Disc [PhD thesis]. Houston, TX: Rice University; April 2008.
2008	Natoli RM. Impact Loading and Functional Tissue Engineering of Articular Cartilage [PhD thesis]. Houston, TX: Rice University; October 2008.
2010	Huey DJ. Development of a Self-Assembled Meniscal Replacement [PhD thesis]. Houston, TX: Rice University; May 2010.
1998	Reid DL. The Distribution and Function of Collagen Receptors on Bovine Articular Chondrocytes [PhD thesis]. Rush University; 1998.
1994	Giori NJ. Mechanical Influences on the Differentiation and Modulation of Skeletal and Connective Tissues [PhD thesis]. Stanford University; July 1994.
2013	Nishimuta JF. Degradation of Cartilage and Meniscus Tissues: An in Vitro Investigation in Osteoarthritis Development [PhD thesis]. Stanford University; March 2013.
2007	Buckley CT. On the Development of Scaffolds for Bone Tissue Engineering [PhD thesis]. Trinity College Dublin; September 2007.
2017	Irvine AD. Modulating Mechanical Cues and Oxygen Availability to Regulate Chondrogenesis Within MSC Laden Hydrogels [PhD thesis]. Trinity College Dublin; June 2017.
2012	Beveridge JE. Surface Interactions and Cartilage Damage in Two Ovine Models of Stifle Injury [PhD thesis]. Calgary, AB: University of Calgary; April 2012.
1997	Doong J-YH. Alteration of Fibroblast Cell Shape and Induction of Procollagenase Synthesis by Calcium Channel Blockers, Calmodulin Inhibitors and Protein Kinase C Inhibitors [PhD thesis]. University of Chicago; March 1997.
1997	Chen AC. Electromechanical Properties of Normal Cartilage and Biomechanical Regulation of Transplanted Chondrocytes: Implications for Articular Cartilage Tissue Engineering [PhD thesis]. San Diego (UCSD), University of California; 1997.
1998	Ahsan T. Integrative Repair and Collagen Crosslinking in Articular Cartilage [PhD thesis]. San Diego (UCSD), University of California; 1998.
2001	Davisson TH. Biophysical Regulation of Metabolic Balance in Tissue Engineered Articular Cartilage [PhD thesis]. San Diego (UCSD), University of California; 2001.
2001	Kurtis MS. Cell Adhesion and Matrix Metabolism Following Chondrocyte Transplantation [PhD thesis]. San Diego (UCSD), University of California; 2001.
2002	Li KW. Regulation of Chondrocytes by Static and Dynamic Loading in Articular Cartilage Repair [PhD thesis]. San Diego (UCSD), University of California; 2002.
2002	Williamson AK. Development and Growth of Bovine Articular Cartilage: Biomechanical Function and Function-Composition Relationships [PhD thesis]. San Diego (UCSD), University of California; 2002.
2005	Klein TJ. Cartilage Tissue Engineering: Biophysical Modulation of Functional Depth-Dependent Properties [PhD thesis]. San Diego (UCSD), University of California; 2005.
2005	McGowan KB. Enhancement of Integrative Cartilage Repair by Manipulation of Extracellular Matrix [PhD thesis]. San Diego (UCSD), University of California; 2005.
2005	Temple MM. Age- and Site-Associated Biomechanical Weakening of Human Articular Cartilage: Relationship to Cellularity, Wear, Matrix Fragmentation and the Progression to Osteoarthritis [PhD thesis]. San Diego (UCSD), University of California; 2005.
2006	Asanbaeva A. Cartilage Growth and Remodeling: Modulation of Growth Phenotype and Tensile Integrity [PhD thesis]. San Diego (UCSD), University of California; 2006.
2006	Chawla K. Mechanisms of Articular Cartilage Defect Repair in Vivo After Implantation of Stratified Cartilaginous Tissue [PhD thesis]. San Diego (UCSD), University of California; 2006.
2006	Jadin KD. Mechanisms of Growth of Articular Cartilage: Cell Organization and Fates [PhD thesis]. San Diego (UCSD), University of California; 2006.
2006	Schmidt TA. Proteoglycan 4 Metabolism and Boundary Lubrication of Articular Cartilage [PhD thesis]. San Diego (UCSD), University of California; 2006.
2008	Blewis ME. Bioengineering Synovial Fluid With Theoretical and Experimental Models of the Synovial Joint [PhD thesis]. San Diego (UCSD), University of California; 2008.
2010	Hwang J. Integration of Cartilage and Bone Through a Calcified Cartilage Interface to Form a Functional Osteochondral Graft [PhD thesis]. San Diego (UCSD), University of California; 2010.
2010	Williams GM. Biophysical and Biochemical Regulation of the Shape, Size, and Maturity of Calf Articular Cartilage [PhD thesis]. San Diego (UCSD), University of California; 2010.
2018	Raleigh A. Biophysical Mechanisms of Disturbances to Synovial Joint Lubricant Homeostasis in Post-Traumatic Osteoarthritis [PhD thesis]. San Diego (UCSD), University of California; 2018.
2006	Staples AK. Mechanical and Biological Mechanisms of Regulating Human Mesenchymal Stem Cell Differentiation [PhD thesis]. San Francisco, University of California; 2006.
2010	Rodriguez AG. Human Endplate Permeability and Microstructure and Their Relationship to Disc Degeneration [PhD thesis]. San Francisco, University of California; 2010.
2010	Jeong GC. The Effects of Designed Scaffold Architecture and Biodegradable Material on Chondrogenesis in Vitro and in Vivo [PhD thesis]. University of Michigan; 2010.
2018	Wu B. Development of Self-Regulatory Gene Circuits for Cartilage Tissue Engineering [PhD thesis]. University of Michigan; 2018.
2000	Fedewa MM. Determinants of Microstructural Load Transfer in Cartilage Tissue from Chondrocyte Culture [PhD thesis]. University of Minnesota; August 2000.

Year	Entry
1986	Schneiderman R, Keret D, Maroudas A. Effects of mechanical and osmotic pressure on the rate of glycosaminoglycan synthesis in the human adult femoral head cartilage: an in vitro study. J Orthop Res. 1986;4(4):393-408.
1988	Gray ML, Pizzanelli AM, Grodzinsky AJ, Lee RC. Mechanical and physicochemical determinants of the chondrocyte biosynthetic response. J Orthop Res. November 1988;6(6):777-792.
1979	Stockwell RA, Meachim G. The chondrocytes. In: Freeman MAR, ed. Adult Articular Cartilage. 2nd ed. Kent, England: Pitman Medical; 1979:69-144.
1983	Hascall VC, Handley CJ, McQuillan DJ, Hascall GK, Robinson H, Lowther DA. The effect of serum on biosynthesis of proteoglycans by bovine articular cartilage in culture. Arch Biochem Biophys. July 1, 1983;224(1):206-223.