Bisphosphonates:​ mechanisms of action

Rodan, Gideon A.<sup>1</sup>; Fleisch, Herbert A.<sup>1</sup>

Affiliations

¹Department of Bone Biology & Osteoporosis, Merck Research Laboratories, West Point, Pennsylvania 19486

²Department of Pathophysiology, University of Berne, Berne 3010, Switzerland

Links

DOI: 10.1172/JCI118722

PubMed: 8675678

WoS: A1996UT42900004

History

Received: 1996-04-15

Accepted: 1996-04-23

Cited Works (6)

Year	Entry
1993	Balena R, Toolan BC, Shea M, Markatos A, Myers ER, Lee SC, Opas EE, Seedor JG, Klein H, Frankenfield D, Quartuccio H, Fioravanti C, Clair J, Brown E, Hayes WC, Rodan GA. The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates. J Clin Invest. December 1993;92(6):2577-2586.
1996	Parfitt AM, Mundy GR, Roodman GD, Hughes DE, Boyce BF. A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates. J Bone Miner Res. February 1996;11(2):150-159.
1990	Watts NB, Harris ST, Genant HK, Wasnich RD, Miller PD, Jackson RD, Licata AA, Ross P, Woodson GC III, Yanover MJ, Mysiw WJ, Kohse L, Rao MB, Steiger P, Richmond B, Chesnut CH III. Intermittent cyclical etidronate treatment of postmenopausal osteoporosis. NEJM. July 12, 1990;323(2):73-79.
1995	Liberman UA, Weiss SR, Bröll J, Minne HW, Quan H, Bell NH, Rodriguez-Portales J, Downs RW Jr, Dequeker J, Favus M, Seeman E, Recker RR, Capizzi T, Santora AC, Lombardi A, Shah RV, Hirsch LJ, Karpf DB; Group, Alendronate Phase III Osteoporosis Treatment Study. Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. NEJM. November 30, 1995;333(22):1437-1443.
1991	Sato M, Grasser W, Endo N, Akins R, Simmons H, Thompson DD, Golub E, Rodan GA. Bisphosphonate action: alendronate localization in rat bone and effects on osteoclast ultrastructure. J Clin Invest. December 1991;88(6):2095-2105.
1952	Amprino R, Engström A. Studies on x-ray absorption and diffraction of bone tissue. Acta Anat. 1952;15(1-2):1-22.

Cited By (23)

Year	Entry
2006	Allen MR, Iwata K, Phipps R, Burr DB. Alterations in canine vertebral bone turnover, microdamage accumulation, and biomechanical properties following 1-year treatment with clinical treatment doses of risedronate or alendronate. Bone. October 2006;39(4):872-879.
2011	Allen MR, Burr DB. Bisphosphonate effects on bone turnover, microdamage, and mechanical properties: what we think we know and what we know that we don't know. Bone. July 2011;49(1):56-65.
2014	Bajaj D, Geissler JR, Allen MR, Burr DB, Fritton JC. The resistance of cortical bone tissue to failure under cyclic loading is reduced with alendronate. Bone. July 2014;64:57-64.
2020	Ha J, Lee J-M, Lim Y, Kim MK, Kwon H-S, Song K-H, Jeon HM, Kang MI, Baek K-H. Effect of bisphosphonate on the prevention of bone loss in patients with gastric cancer after gastrectomy: a randomized controlled trial. Bone. January 2020;130:115138.
2020	Lesclous P, Cloitre A, Catros S, Devoize L, Louvet B, Châtel C, Foissac F, Roux C. Alendronate or zoledronic acid do not impair wound healing after tooth extraction in postmenopausal women with osteoporosis. Bone. August 2020;137:115412.
2001	Li J, Mashiba T, Burr DB. Bisphosphonate treatment suppresses not only stochastic remodeling but also the targeted repair of microdamage. Calcif Tiss Int. November 2001;69(5):281-286.
2005	Riggs BL, Parfitt AM. Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodeling. J Bone Miner Res. February 2005;20(2):177-184.
1999	Plotkin LI, Weinstein RS, Parfitt AM, Roberson PK, Manolagas SC, Bellido T. Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. J Clin Invest. November 1999;104(10):1363-1374.
2004	Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff SL. Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J Oral Maxillofac Surg. May 2004;62(5):527-534.
2004	Day JS, Ding M, Bednarz P, van der Linden JC, Mashiba T, Hirano T, Johnston CC, Burr DB, Hvid I, Sumner DR, Weinans H. Bisphosphonate treatment affects trabecular bone apparent modulus through micro-architecture rather than matrix properties. J Orthop Res. May 2004;22(3):465-471.
2009	Tang SY, Allen MR, Phipps R, Burr DB, Vashishth D. Changes in non-enzymatic glycation and its association with altered mechanical properties following 1-year treatment with risedronate or alendronate. Osteoporos Int. July 2009;20(6):887-894.
2021	Fang Y, Morse LR, Nguyen N, Battaglino RA, Goldstein RF, Troy KL. Functional electrical stimulation (FES)–assisted rowing combined with zoledronic acid, but not alone, preserves distal femur strength and stiffness in people with chronic spinal cord injury. Osteoporos Int. March 2021;32(3):549-558.
2017	Lloyd AA, Gludovatz B, Riedel C, Luengo EA, Saiyed R, Marty E, Lorich DG, Lane JM, Ritchie RO, Busse B, Donnelly E. Atypical fracture with long-term bisphosphonate therapy is associated with altered cortical composition and reduced fracture resistance. Proc Natl Acad Sci USA. August 15, 2017;114(33):8722-8727.
2008	Livingston EW. Risedronate Prevents Early Bone Loss Resulting from Whole-Body Irradiation [Master's thesis]. Clemson, SC: Clemson University; August 2008.
2005	Day JS. Bone Quality: The Mechanical Effects of Microarchitecture and Matrix Properties [PhD thesis]. Erasmus University Rotterdam; 2005.
2011	Ross RD. Functionalized Gold Nanoparticles as Damage-Specific X-Ray Computed Tomography Contrast Agents in Bone Tissue [PhD thesis]. University of Notre Dame; November 2011.
2007	Tang SY-C. Effects of Non-Enzymatic Glycation on the Biomechanical Behavior of Bone [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; 2007.
2014	Bradke BS. The Role of Cortical and Cancellous Bone Quality on Vertebral Fragility [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; April 2014.
2020	Loundagin LL. The Influence of Intracortical Microarchitecture on the Mechanical Fatigue of Bone [PhD thesis]. Calgary, AB: University of Calgary; July 2020.
2003	Nyman JS. Simulations of Bone Adaptation to Total Knee Arthroplasty and Bisphosphonates Through Remodeling Stimulated by Microdamage and Disuse [PhD thesis]. Davis, University of California; 2003.
2013	Davis MS. Microdamage: Its Role in the Mechanical Integrity of Low Bone Mass Diseases and Its Treatment Implications [PhD thesis]. University of Michigan; 2013.
2015	Ng AH-M. A Mouse Model of Adynamic Bone Disease (ABD) and Its Consequences on Bone Quality With Age [PhD thesis]. University of Toronto; 2015.
2018	Fang Y. Investigation of Bone Loading in FES-Assisted Rowing and Its Effect on Preventing Bone Loss in People With Spinal Cord Injury [PhD thesis]. Worcester, MA: Worcester Polytechnic Institute; August 2018.