Detraining effects after 18 months of high intensity resistance training on osteosarcopenia in older men:​ six-month follow-up of the randomized controlled Franconian Osteopenia and Sarcopenia Trial (FrOST)

Kemmler, Wolfgang; Kohl, Matthias; Fröhlich, Michael; Schoene, Daniel; von Stengel, Simon

Affiliations

¹Institute of Medical Physics, Friedrich-Alexander University of Erlangen-Nürnberg, 91052 Erlangen, Germany

²Faculty Medical and Life Sciences, University of Furtwangen, 78054 Villingen-Schwenningen, Germany

³Department of Sports Science, University of Kaiserslautern, 67663 Kaiserslautern, Germany

Abstract and keywords

Purpose: Detraining after dedicated exercise programs might be a frequent situation in older people's exercise patterns. The aim of the present study was thus to determine the effects of 6 months of detraining after 18 months of high intensity resistance exercise (HIT-RT) on musculoskeletal outcomes in older men with sarcopenia.

Methods: Community-dwelling men aged 72 years and older with osteosarcopenia (n = 43) were randomly assigned to an 18-month HIT-RT (EG: n = 21) or a non-training control group (CG, n = 22). After the intervention, participants of the EG stopped HIT-RT for 6 months, but continued their habitual physical activity. Study outcomes were skeletal muscle mass index, bone mineral density (BMD) at the lumbar-spine and total-hip, maximum hip/leg-extensor strength, handgrip strength and gait velocity. We applied an intention-to-treat analysis with multiple imputation.

Results: Changes in the HIT-RT were much more pronounced during the detraining period compared with the CG, although this effect was only significant for skeletal muscle mass index and hip-/leg-extensor strength (p = .002 and p = .013), but not for lumbar-spine BMD (p = .068), total-hip BMD (p = .069), handgrip strength (p = .066) or gait velocity (p = .067). Apart from total-hip BMD (p = .055), handgrip strength (p = .069) and gait velocity (p = .881) values of the HIT-RT group decreased significantly during detraining. However, after 24 months, overall effects (p < .001) were still observed for skeletal muscle mass index and hip-/leg-extensor strength.

Conclusion: Although unable to state from which point in time relevant detraining effects emerge, we conclude that health care providers should focus on continuous rather than intermitted exercise programs for older people.

Clinical trial number: clinicalTrials.gov: NCT03453463; NCT04444661.

Keywords: Resistance exercise; Detraining; Sarcopenia; Bone mineral density; Older men

Links

DOI: 10.1016/j.bone.2020.115772

PubMed: 33249320

WoS: 000601336000004

History

Received: 2020-09-24

Revised: 2020-11-23

Accepted: 2020-11-23

Online: 2020-11-26

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Cited By (1)

Year	Entry
2022	Zitzmann A-L, Shojaa M, Kast S, Kohl M, von Stengel S, Borucki D, Gosch M, Jakob F, Kerschan-Schindl K, Kladny B, Lange U, Middeldorf S, Peters S, Schoene D, Sieber C, Thomasius F, Uder M, Kemmler W. The effect of different training frequency on bone mineral density in older adults: a comparative systematic review and meta-analysis. Bone. January 2022;154:116230.