Bone metastases present in more than 85% of cancer patients at the time of death, with the spine being the most common site. Improvements in radiofrequency ablation (RFA) has adapted this technology for local control of spinal metastases. In this thesis, a navigation workflow for vertebral RFA was developed utilizing software to integrate pre-procedural imaging data with RFA treatment plans and intra-procedural imaging data. An optical tracking camera is utilized to track the RFA probe intraoperatively and to ensure that the final pose matches the prescribed pose. The feasibility of the workflow was evaluated by two spine surgeons in animal studies. The accuracy of the navigation was also tested in phantom and animal models. The developed software yields a clinically feasible workflow similar to the existing systems adopted in procedure rooms. Navigated RFA may improve the safety and efficacy of this procedure, and ultimately enhance quality of life for patients.