High bone turnover is intrinsically harmful:​ two paths to a similar conclusion:​ the Parfitt view

Parfitt, A. Michael<sup>1</sup>

Affiliations

¹Division of Endocrinology, UAMS Center for Osteoporosis & Metabolic Bone Disease, Little Rock, AR, USA

Links

DOI: 10.1359/jbmr.2002.17.8.1558

PubMed: 12162510

WoS: 000177048900025

History

Online: 2002-08-1

Cited Works (6)

Year	Entry
1983	Parfitt AM, Mathews CH, Villanueva AR, Kleerekoper M, Frame B, Rao DS. Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis: implications for the microanatomic and cellular mechanisms of bone loss. J Clin Invest. October 1983;72(4):1396-1409.
1996	Riggs BL, Melton LJ III, O'Fallon WM. Drug therapy for vertebral fractures in osteoporosis: evidence that decreases in bone turnover and increases in bone mass both determine antifracture efficacy. Bone. March 1996;18(3)(suppl 1):197S-201S.
1992	Einhorn TA. Bone strength: the bottom line. Calcif Tiss Int. November 1992;51(5):333-339.
1992	Lufkin EG, Wahner HW, O'Fallon WM, Hodgson SF, Kotowicz MA, Lane AW, Judd HL, Caplan RH, Riggs BL. Treatment of postmenopausal osteoporosis with transdermal estrogen. Ann Intern Med. July 1, 1992;117(1):1-9.
2002	Riggs BL, Melton LJ III. Bone turnover matters: the raloxifene treatment paradox of dramatic decreases in vertebral fractures without commensurate increases in bone density. J Bone Miner Res. January 2002;17(1):11-14.
1988	Mosekilde L. Age-related changes in vertebral trabecular bone architecture—assessed by a new method. Bone. 1988;9(4):247-250.

Cited By (21)

Year	Entry
2004	Borah B, Dufresne TE, Chmielewski PA, Johnson TD, Chines A, Manhart MD. Risedronate preserves bone architecture in postmenopausal women with osteoporosis as measured by three-dimensional microcomputed tomography. Bone. April 2004;34(4):736-746.
2006	Hernandez CJ, Keaveny TM. A biomechanical perspective on bone quality. Bone. December 2006;39(6):1173-1181.
2009	Tkachenko EV, Slyfield CR, Tomlinson RE, Daggett JR, Wilson DL, Hernandez CJ. Voxel size and measures of individual resorption cavities in three-dimensional images of cancellous bone. Bone. September 2009;45(3):487-492.
2012	Goff MG, Slyfield CR, Kummari SR, Tkachenko EV, Fischer SE, Yi YH, Jekir MG, Keaveny TM, Hernandez CJ. Three-dimensional characterization of resorption cavity size and location in human vertebral trabecular bone. Bone. July 2012;51(1):28-37.
2007	Eswaran SK, Allen MR, Burr DB, Keaveny TM. A computational assessment of the independent contribution of changes in canine trabecular bone volume fraction and microarchitecture to increased bone strength with suppression of bone turnover. J Biomech. 2007;40(15):3424-3431.
2006	Hernandez CJ, Gupta A, Keaveny TM. A biomechanical analysis of the effects of resorption cavities on cancellous bone strength. J Bone Miner Res. August 2006;21(8):1248-1255.
2022	Ott SM. Consider the bisphosphonate dose. J Bone Miner Res. 2022;37(1):1-2.
2011	Karim L, Vashishth D. Role of trabecular microarchitecture in the formation, accumulation, and morphology of microdamage in human cancellous bone. J Orthop Res. November 2011;29(11):1739-1744.
2009	Slyfield CR Jr. Automated Sub-Micron Resolution Serial Block Face Imaging of Cancellous Bone Using Epifluorescence Microscopy [Master's thesis]. Cleveland, OH: Case Western Reserve University; January 2009.
2011	Kummari SR. Experimental and Computational Evaluation of Microscopic Tissue Damage and Remodeling Cavities in Trabecular Bone [PhD thesis]. Cleveland, OH: Case Western Reserve University; May 2011.
2011	Tkachenko E. Measures of Individual Resorption Cavities in Three-Dimensional Images in Cancellous Bone [Master's thesis]. Cleveland, OH: Case Western Reserve University; May 2011.
2007	Yuan Y. The Differential Effects of Two Critical Osteoclastogenesis Stimulating Factors on Bone Biomechanics [PhD thesis]. Clemson, SC: Clemson University; May 2007.
2008	Livingston EW. Risedronate Prevents Early Bone Loss Resulting from Whole-Body Irradiation [Master's thesis]. Clemson, SC: Clemson University; August 2008.
2012	Slyfield CR Jr. The Biomechanics of Bone Turnover [PhD thesis]. Ithaca, NY: Cornell University; January 2012.
2015	Goff M. The Role of Micro and Ultra-Structure in Microdamage Accumulation in Cancellous Bone [PhD thesis]. Ithaca, NY: Cornell University; August 2015.
2017	Matheny JB. Interactions Between Bone Remodeling and Microdamage in Cancellous Bone [PhD thesis]. Ithaca, NY: Cornell University; August 2017.
2007	Schneider P. Ultrastructural Phenotyping of Murine Bone Using Synchrotron Micro- and Nano-Computed Tomography [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2007.
2011	Karim L. The Biomolecular Basis of Bone Fracture [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; November 2011.
2008	Kennedy OD. The Effect of Bone Turnover on Bone Quality and Material Properties [PhD thesis]. Trinity College Dublin; 2008.
2013	Eleazer CD. The Interaction of Mechanical Loading and Metabolic Stress on Human Cortical Bone: Testing Anthropological Assumptions Using Cross-Sectional Geometry and Histomorphology [PhD thesis]. Knoxville, University of Tennessee; August 2013.
2013	Liu CC. Effects of a New Conjugate Drug in a Rat Model of Postmenopausal Osteoporosis [Master's thesis]. University of Toronto; 2013.