In Pursuit of Accurate Structural and Mechanical Osteocyte Mechanotransduction Models

Year	Entry
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1990	Schneider EL, Guralnik JM. The aging of America: impact on health care costs. JAMA. May 2, 1990;263(17):2335-2340.
1977	Parfitt AM. The cellular basis of bone turnover and bone loss: a rebuttal of the osteocytic resorption—bone flow theory. Clin Orthop Relat Res. September 1977;127:236-247.
1970	Chamay A. Mechanical and morphological aspect of experimental overload and fatigue in bone. J Biomech. May 1970;3(3):263-270.
1996	Mikuni-Takagaki Y, Suzuki Y, Kawase T, Saito S. Distinct responses of different populations of bone cells to mechanical stress. Endocrinology. May 1996;137(5):2028-2035.
1998	Yasuda H, Shima N, Akagawa NN, Yamaguchi K, Kinosaki M, Mochizuki S-I, Omoyasu AT, Yano K, Goto M, Murakami A, Tsuda E, Morinaga T, Igashio KH, Udagawa N, Tkahashi N, Suda T. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA. March 31, 1998;95(7):3597-3602.
1977	Carter DR, Hayes WC. Compact bone fatigue damage: a microscopic examination. Clin Orthop Relat Res. September 1977;127:265-274.
1994	Torrance AG, Mosley JR, Suswillo RFL, Lanyon LE. Noninvasive loading of the rat ulna in vivo induces a strain-related modeling response uncomplicated by trauma or periostal pressure. Calcif Tiss Int. March 1994;54(3):241-247.
1998	Kawata A, Mikuni-Takagaki Y. Mechanotransduction in stretched osteocytes: temporal expression of immediate early and other genes. Biochem Biophys Res Commun. May 19, 1998;246(2):404-408.
2001	Nicolella DP, Nicholls AE, Lankford J, Davy DT. Machine vision photogrammetry: a technique for measurement of microstructural strain in cortical bone. J Biomech. January 2001;34(1):135-139.
1995	Rawlinson SCF, Mosley JR, Suswillo RFL, Pitsillides AA, Lanyon LE. Calvarial and limb bone cells in organ and monolayer culture do not show the same early responses to dynamic mechanical strain. J Bone Miner Res. 1995;10(8):1225-1232.
1995	Pitsillides AA, Rawlinson SCF, Suswillo RFL, Bourrin S, Zaman G, Lanyon LE. Mechanical strain‐induced NO production by bone cells: a possible role in adaptive bone (re)modeling? FASEB J. December 1995;9(15):1614-1622.
1995	Bay BK. Texture correlation: a method for the measurement of detailed strain distributions within trabecular bone. J Orthop Res. March 1995;13(2):258-267.
1996	Rawlinson SCF, Pitsillides AA, Lanyon LE. Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain. Bone. December 1996;19(6):609-614.
1997	Mori S, Harruff R, Ambrosius W, Burr DB. Trabecular bone volume and microdamage accumulation in the femoral heads of women with and without femoral neck fractures. Bone. December 1997;21(6):521-526.
1992	Cooper C, Campion G, Melton LJ III. Hip fractures in the elderly: a world-wide projection. Osteoporos Int. November 1992;2(6):285-289.
1989	Burr DB, Schaffler MB, Yang KH, Lukoschek M, Sivaneri N, Blaha JD, Radin EL. Skeletal change in response to altered strain environments: is woven bone a response to elevated strain? Bone. 1989;10(3):223-233.
1992	Marotti G, Ferretti M, Muglia M, Palumbo C, Palazzini S. A quantitative evaluation of osteoblast-osteocyte relationships on growing endosteal surface of rabbit tibiae. Bone. July–August 1992;13(5):363-368.
1999	Bay BK, Yerby SA, McLain RF, Toh E. Measurement of strain distributions within vertebral body sections by texture correlation. Spine. January 1, 1999;24(1):10-17.
2000	Fritton SP, McLeod KJ, Rubin CT. Quantifying the strain history of bone: spatial uniformity and self-similarity of low-magnitude strains. J Biomech. March 2000;33(3):317-325.
1995	Cowin SC, Weinbaum S, Zeng Y. A case for bone canaliculi as the anatomical site of strain generated potentials. J Biomech. November 1995;28(11):1281-1297.
2000	Knothe Tate M, Knothe U. An ex vivo model to study transport processes and fluid flow in loaded bone. J Biomech. February 2000;33(2):247-254.
2001	Cukierman E, Pankov R, Stevens DR, Yamada KM. Taking cell-matrix adhesions to the third dimension. Science. November 23, 2001;294(5547):1708-1712.
1981	Doty SB. Morphological evidence of gap junctions between bone cells. Calcif Tiss Int. 1981;33(5):509-512.
1994	Zeng Y, Cowin SC, Weinbaum S. A fiber matrix model for fluid flow and streaming potentials in the canaliculi of an osteon. Ann Biomed Eng. May–June 1994;22(3):280-292.
2000	Knothe Tate ML, Steck R, Forwood MR, Niederer P. In vivo demonstration of load-induced fluid flow in the rat tibia and its potential implications for processes associated with functional adaptation. J Exp Biol. September 2000;203(18):2737-2745.
1995	Schaffler MB, Choi K, Milgrom C. Aging and matrix microdamage accumulation in human compact bone. Bone. December 1995;17(6):521-525.
1982	Lanyon LE, Goodship AE, Pye CJ, MacFie JH. Mechanically adaptive bone remodelling. J Biomech. 1982;15(3):141-154.
1993	Dallas SL, Zaman G, Pead MJ, Lanyon LE. Early strain-related changes in cultured embryonic chick tibiotarsi parallel those associated with adaptive modeling in vivo. J Bone Miner Res. March 1993;8(3):251-259.
1996	Courtney AC, Hayes WC, Gibson LJ. Age-related differences in post-yield damage in human cortical bone: experiment and model. J Biomech. November 1996;29(11):1463-1471.
2003	Noble BS, Peet N, Stevens HY, Brabbs A, Mosley JR, Reilly GC, Reeve J, Skerry TM, Lanyon LE. Mechanical loading: biphasic osteocyte survival and targeting of osteoclasts for bone destruction in rat cortical bone. Am J Physiol Cell Physiol. April 2003;284(4):C934-C943.
1991	Turner CH, Akhter MP, Raab DM, Kimmel DB, Recker RR. A noninvasive, in vivo model for studying strain adaptive bone modeling. Bone. 1991;12(2):73-79.
1992	Gross TS, McLeod KJ, Rubin CT. Characterizing bone strain distributions in vivo using three triple rosette strain gages. J Biomech. September 1992;25(9):1081-1087.
2000	Reilly GC. Observations of microdamage around osteocyte lacunae in bone. J Biomech. September 2000;33(9):1131-1134.
1997	Guldberg RE, Caldwell NJ, Guo XE, Goulet RW, Hollister SJ, Goldstein SA. Mechanical stimulation of tissue repair in the hydraulic bone chamber. J Bone Miner Res. August 1997;12(8):1295-1302.
2001	Cheng B, Zhao S, Luo J, Sprague E, Bonewald LF, Jiang JX. Expression of functional gap junctions and regulation by fluid flow in osteocyte-like MLO-Y4 cells. J Bone Miner Res. February 2001;16(2):249-259.
1982	Rubin CT, Lanyon LE. Limb mechanics as a function of speed and gait: a study of functional strains in the radius and tibia of horse and dog. J Exp Biol. December 1982;101:187-211.
1985	Rubin CT, Lanyon LE. Regulation of bone mass by mechanical strain magnitude. Calcif Tiss Int. 1985;37(4):411-417.
1984	Rubin CT, Lanyon LE. Regulation of bone formation by applied dynamic loads. J Bone Joint Surg. March 1984;66A(3):397-402.
2000	Yellowley CE, Li Z, Zhou Z, Jacobs CR, Donahue HJ. Functional gap junctions between osteocytic and osteoblastic cells. J Bone Miner Res. February 2000;15(2):209-217.
1981	Carter DR, Caler WE, Spengler DM, Frankel VH. Fatigue behavior of adult cortical bone: the influence of mean strain and strain range. Acta Orthop Scand. 1981;52(5):481-490.
2000	Verborgt O, Gibson GJ, Schaffler MB. Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo. J Bone Miner Res. January 2000;15(1):60-67.
1995	Lean JM, Jagger CJ, Chambers TJ, Chow JWM. Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation. Am J Physiol Endocrinol Metab. February 1995;268(1):E318-E327.
1989	Burr DB, Schaffler MB, Yang KH, Wu DD, Lukoschek M, Kandzari D, Sivaneri N, Blaha JD, Radin EL. The effects of altered strain environments on bone tissue kinetics. Bone. 1989;10(3):215-221.
1997	Maniotis AJ, Chen CS, Ingber DE. Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure. Proc Natl Acad Sci USA. February 1997;94(3):849-854.
1984	Menton DN, Simmons DJ, Chang S-L, Orr BY. From bone lining cell to osteocyte: an SEM study. Anat Rec. May 1984;209(1):29-39.
1998	Bentolila V, Boyce TM, Fyhrie DP, Drumb R, Skerry TM, Schaffler MB. Intracortical remodeling in adult rat long bones after fatigue loading. Bone. September 1998;23(3):275-281.
1994	Weinbaum S, Cowin SC, Zeng Y. A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses. J Biomech. March 1994;27(3):339-360.
1997	Klein‐Nulend J, Burger EH, Semeins CM, Raisz LG, Pilbeam CC. Pulsating fluid flow stimulates prostaglandin release and inducible prostaglandin g/h synthase mrna expression in primary mouse bone cells. J Bone Miner Res. January 1997;12(1):45-51.
1999	Zaman G, Pitsillides AA, Rawlinson SCF, Suswillo RFL, Mosley JR, Cheng MZ, Platts LAM, Hukkanen M, Polak JM, Lanyon LE. Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes. J Bone Miner Res. July 1999;14(7):1123-1131.
1996	Fox SW, Chambers TJ, Chow JW. Nitric oxide is an early mediator of the increase in bone formation by mechanical stimulation. Am J Physiol Endocrinol Metab. June 1996;270(6):E955-E960.
1981	Carter DR, Vasu R, Spengler DM, Dueland RT. Stress fields in the unplated and plated canine femur calculated from in vivo strain measurements. J Biomech. 1981;14(1):63-70.
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2000	You J, Yellowley CE, Donahue HJ, Zhang Y, Chen Q, Jacobs CR. Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading-induced oscillatory fluid flow. J Biomech Eng. August 2000;122(4):387-393.
1996	Ajubi NE, Klein-Nulend J, Nijweide PJ, Vrijheid-Lammers T, Alblas MJ, Burger EH. Pulsating fluid flow increases prostaglandin production by cultured chicken osteocytes: a cytoskeleton-dependent process. Biochem Biophys Res Commun. August 5, 1996;225(1):62-68.
1982	O'Connor JA, Lanyon LE, MacFie H. The influence of strain rate on adaptive bone remodelling. J Biomech. 1982;15(10):767-781.
2001	You L, Cowin SC, Schaffler MB, Weinbaum S. A model for strain amplification in the actin cytoskeleton of osteocytes due to fluid drag on pericellular matrix. J Biomech. November 2001;34(11):1375-1386.
1983	Martens M, Van Audekercke R, Delport P, De Meester P, Mulier JC. The mechanical characteristics of cancellous bone at the upper femoral region. J Biomech. 1983;16(12):971-983.
1997	Mosley JR, March BM, Lynch J, Lanyon LE. Strain magnitude related changes in whole bone architecture in growing rats. Bone. March 1997;20(3):191-198.
1999	Ajubi NE, Klein-Nulend J, Alblas MJ, Burger EH, Nijweide PJ. Signal transduction pathways involved in fluid flow-induced PGE₂ production by cultured osteocytes. Am J Physiol Endocrinol Metab. January 1999;276(1):E171-E178.
1999	Takano Y, Turner CH, Owan I, Martin RB, Lau ST, Forwood MR, Burr DB. Elastic anisotropy and collagen orientation of osteonal bone are dependent on the mechanical strain distribution. J Orthop Res. January 1999;17(1):59-66.

Year	Entry
2010	Joiner DM. The Effect of Age on Bone and Its Response to Mechanical Stimulation [PhD thesis]. University of Michigan; 2010.
2010	Soves CP. The Potential Role of Megakaryocytes in Mechanically Mediated Bone Adaptation [PhD thesis]. University of Michigan; 2010.