Head injury in man and experimental animals:​ neuropathology

Adams, J. H.<sup>1</sup>; Graham, D. I.<sup>1</sup>; Gennarelli, T. A.<sup>2</sup>

Affiliations

¹Department of Neuropathology, Institute of Neurological Sciences, Glasgow, Scotland

²Division of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.

Abstract and keywords

Ali ofthe principal types ofbrain damage that occur in man as a result of a nonmissile head injury, viz. cerebral contusions, intracranial haematoma, raised intracranial pressure, diffuse axonal injury, diffuse hypoxic damagc, and diffuse swelling ha ve been produced in subhuman primates subjected to inertial, i.e. nonimpact, controlled angular acceleration of the head through 60° in the sagittal, oblique and lateral planes.

Keywords: Head injury; man; experimental; diffuse axonal injury

Links

DOI: 10.1007/978-3-7091-4147-2_2

PubMed: 6581702

Cited Works (8)

Year	Entry
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1982	Gennarelli TA, Thibault LE, Adams JH, Graham DI, Thompson CJ, Marcincin RP. Diffuse axonal injury and traumatic coma in the primate. Ann Neurol. 1982;12(6):564-574.
1982	Gennarelli TA, Spielman GM, Langfitt TW, Gildenberg PL, Harrington T, Jane JA, Marshall LF, Miller JD, Pitts LH. Influence of the type of intracranial lesion on outcome from severe head injury: a multicenter study using a new classification system. J Neurosurg. January 1982;56(1):26-32.

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1997	Ruan JS, Khalil TB, King AI. Impact head injury analysis using an explicit finite element human head model. J Traffic Med. 1997;25(1-2):33-40.
2007	Yoganandan N, Gennarelli TA, Pintar FA. Characterizing diffuse brain injuries from real-world motor vehicle impacts. In: Proceedings of the 20th International Technical Conference on the Enhanced Safety of Vehicles (ESV). June 18-21, 2007; Lyon, France.
2006	Fijalkowski RJ, Stemper BD, Ellingson BM, Yoganandan N, Pintar FA, Gennarelli TA. Inducing mild traumatic brain injury in the rodent through coronal plane angular acceleration. In: Proceedings of the 2006 International IRCOBI Conference on the Biomechanics of Impact. September 20-22, 2006; Madrid, Spain.115-125.
2015	Stemper BD, Shah AS, Budde MD, Chiariello R, Wilkins N, Olsen C, Mehta P, Kurpad SN, McCrea M, Pintar FA. Characterization of differing time‐course of cognitive deficits and emotional changes following rotational traumatic brain injury in the rat. In: Proceedings of the 2015 International IRCOBI Conference on the Biomechanics of Injury. September 9-11, 2015; Lyon, France.198-207.
2001	Zhang L, Yang KH, Dwarampudi R, Omori K, Li T, Chang K, Hardy WN, Khalil TB, King AI. Recent advances in brain injury research: a new human head model development and validation. Stapp Car Crash J. 2001;45:369-394. SAE 2001-22-0017.
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1989	Gennarelli TA, Thibault LE, Tipperman R, Tomei G, Sergot R, Brown M, Maxwell WL, Graham DI, Adams JH, Irvine A, Gennarelli LM, Duhaime AC, Boock R, Greenberg J. Axonal injury in the optic nerve: a model simulating diffuse axonal injury in the brain. J Neurosurg. August 1989;71(2):244-253.
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2007	Fijalkowski RJ, Stemper BD, Pintar FA, Yoganandan N, Crowe MJ, Gennarelli TA. New rat model for diffuse brain injury using coronal plane angular acceleration. J Neurotrauma. August 2007;24(8):1387-1398.
2009	Yoganandan N, Gennarelli TA, Zhang J, Pintar FA, Takhounts E, Ridella SA. Association of contact loading in diffuse axonal injuries from motor vehicle crashes. J Trauma. February 2009;66(2):309-315.
2000	Smith DH, Meaney DF. Axonal damage in traumatic brain injury. Neuroscientist. December 2000;6(6):483-495.
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2008	Fijalkowski RJ. Rotational Acceleration Pulse Characteristics Affect Mild Diffuse Brain Injury Severity [PhD thesis]. Marquette University; May 2008.
2018	Tierney G. A Biomechanical Assessment of Direct and Inertial Head Loading in Rugby Union [PhD thesis]. Dublin, Ireland: Trinity College Dublin; 2018.
2013	Post A. The Influence of Dynamic Response Characteristics on Traumatic Brain Injury [PhD thesis]. Ottawa, ON: University of Ottawa; 2013.
2014	Rousseau P. Analysis of Concussion Metrics of Real-World Concussive and Non-Injurious Elbow and Shoulder to Head Collisions in Ice Hockey [PhD thesis]. Ottawa, ON: University of Ottawa; 2014.
2016	Kendall M. Comparison and Characterization of Different Concussive Brain Injury Events [PhD thesis]. University of Ottawa; 2016.
2009	Eucker SA. Effect of Head Rotation Direction on Closed Head Injury in Neonatal Piglets [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2009.
1994	Ruan JS. Impact Biomechanics of Head Injury by Mathematical Modeling [PhD thesis]. Detroit, MI: Wayne State University; 1994.
2001	Zhang L. Computational Biomechanics of Traumatic Brain Injury: An Investigation of Head Impact Response and American Football Head Injury [PhD thesis]. Detroit, MI: Wayne State University; May 2001.
2007	Hardy WN. Response of the Human Cadaver Head to Impact [PhD thesis]. Detroit, MI: Wayne State University; December 2007.
2011	Kumaran S. Subacute Effect of Olfactory Mucosal Stem Cells in the Treatment of Traumatic Brain Injury [Master's thesis]. Detroit, MI: Wayne State University; December 2011.
2011	Zakaria N. Comparison of Progression of Diffuse Axonal Injury With Histology and Diffusion Tensor Imaging [PhD thesis]. Detroit, MI: Wayne State University; 2011.
2023	Lyu D. Investigation of Biomechanical Thresholds of Mild to Severe Brain Injury Using an Anisotropic Visco-Hyperelastic Finite Element Head Model: Model Development and Simulation of Impact Injury and Blast Injury [PhD thesis]. Detroit, MI: Wayne State University; August 2023.