Understanding bone strength:​ size isn’t everything

van der Meulen, M. C. H.; Jepsen, K. J.; Mikić, B.

Affiliations

¹Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA

²Biomechanics and Biomaterials Section, Research Division, Hospital for Special Surgery, New York, NY, USA

³Department of Orthopedics, Mount Sinai School of Medicine, New York, NY, USA

⁴Picker Engineering Program, Smith College, Northampton, MA, USA

Links

DOI: 10.1016/S8756-3282(01)00491-4

PubMed: 11502469

ISI: 000170696700001

History

Received: 2000-11-15

Revised: 2001-02-16

Accepted: 2001-03-20

Cited Works (15)

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1996	Jepsen KJ, Goldstein SA, Kuhn JL, Schaffler MB, Bonadio J. Type‐I collagen mutation compromises the post‐yield behavior of Mov13 long bone. J Orthop Res. May 1996;14(3):493-499.
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1982	Rubin CT, Lanyon LE. Limb mechanics as a function of speed and gait: a study of functional strains in the radius and tibia of horse and dog. J Exp Biol. December 1982;101:187-211.
1996	Beamer WG, Donahue LR, Rosen CJ, Baylink DJ. Genetic variability in adult bone density among inbred strains of mice. Bone. May 1996;18(5):397-403.
1999	Brodt MD, Ellis CB, Silva MJ. Growing C57Bl/6 mice increase whole bone mechanical properties by increasing geometric and material properties. J Bone Miner Res. December 1999;14(12):2159-2166.
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1997	Jepsen KJ, Schaffler MB, Kuhn JL, Goulet RW, Bonadio J, Goldstein SA. Type I collagen mutation alters the strength and fatigue behavior of Mov13 cortical tissue. J Biomech. November–December 1997;30(11-12):1141-1147.
1998	Akhter MP, Cullen DM, Pedersen EA, Kimmel DB, Recker RR. Bone response to in vivo mechanical loading in two breeds of mice. Calcif Tiss Int. November 1998;63(5):442-449.
2000	Turner CH, Hsieh Y, Müller R, Bouxsein ML, Baylink DJ, Rosen CJ, Grynpas MD, Donahue LR, Beamer WG. Genetic regulation of cortical and trabecular bone strength and microstructure in inbred strains of mice. J Bone Miner Res. June 2000;15(6):1126-1131.
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Cited By (23)

Year	Entry
2006	Hernandez CJ, Keaveny TM. A biomechanical perspective on bone quality. Bone. December 2006;39(6):1173-1181.
2008	Nyman JS, Ni Q, Nicolella DP, Wang X. Measurements of mobile and bound water by nuclear magnetic resonance correlate with mechanical properties of bone. Bone. January 2008;42(1):193-199.
2013	Burket JC, Brooks DJ, MacLeay JM, Baker SP, Boskey AL, van der Meulen MCH. Variations in nanomechanical properties and tissue composition within trabeculae from an ovine model of osteoporosis and treatment. Bone. January 2013;52(1):326-336.
2005	Busa B, Miller LM, Rubin CT, Qin Y-X, Judex S. Rapid establishment of chemical and mechanical properties during lamellar bone formation. Calcif Tiss Int. December 2005;77(6):386-394.
2010	Donnelly E, Chen DX, Boskey AL, Baker SP, van der Meulen MCH. Contribution of mineral to bone structural behavior and tissue mechanical properties. Calcif Tiss Int. November 2010;87(5):450-460.
2011	Donnelly E. Methods for assessing bone quality: a review. Clin Orthop Relat Res. August 2011;469:2128-2138.
2011	Cole JH, van der Meulen MCH. Whole bone mechanics and bone quality. Clin Orthop Relat Res. August 2011;469(8):2139-2149.
2016	Hunt HB, Donnelly E. Bone quality assessment techniques: geometric, compositional, and mechanical characterization from macroscale to nanoscale. Clin Rev Bone Miner Metab. September 2016;14(3):133-149.
2004	Silva MJ, Brodt MD, Fan Z, Rho J-Y. Nanoindentation and whole-bone bending estimates of material properties in bones from the senescence accelerated mouse SAMP6. J Biomech. November 2004;37(11):1639-1646.
2005	Boskey AL, Mendelsohn R. Infrared analysis of bone in health and disease. J Biomed Opt. May–June 2005;10(3):031102.
2005	Tommasini SM, Morgan TG, van der Meulen MCH, Jepsen KJ. Genetic variation in structure‐function relationships for the inbred mouse lumbar vertebral body. J Bone Miner Res. May 2005;20(5):817-827.
2007	Glatt V, Canalis E, Stadmeyer L, Bouxsein ML. Age‐related changes in trabecular architecture differ in female and male C57BL/6J mice. J Bone Miner Res. August 2007;22(8):1197-1207.
2007	Nyman JS, Roy A, Tyler JH, Acuna RL, Gayle HJ, Wang X. Age‐related factors affecting the postyield energy dissipation of human cortical bone. J Orthop Res. May 2007;25(7):646-655.
2003	Jepsen KJ, Akkus OJ, Majeska RJ, Nadeau JH. Hierarchical relationship between bone traits and mechanical properties in inbred mice. Mamm Genome. February 2003;14(2):97-104.
2013	Burket JC. Alterations in Tissue Composition and Nanomechanical Properties With Ageing, Osteoporosis, and Treatment [PhD thesis]. Ithaca, NY: Cornell University; January 2013.
2018	Chen JTH. Alterations in Bone Tissue Properties With Parathyroid Hormone Treatment [PhD thesis]. Ithaca, NY: Cornell University; May 2018.
2018	Hunt HB. Characterization of Material Properties, Microarchitecture, and Mechanics of Bone from Subjects With Type 2 Diabetes Mellitus [PhD thesis]. Ithaca, NY: Cornell University; December 2018.
2021	Scott MC. Exercise and Bone: Older Adults, Type II Diabetes, and Ketogenic Diets [PhD thesis]. Louisiana State University; May 2021.
2017	Mathavan N. The Anabolic - Anti-Catabolic Paradigm of Augmenting Skeletal Regeneration: A Bone Quality Perspective [PhD thesis]. Lund, Sweden: Lund University; 2017.
2004	Giangregorio L. Musculoskeletal Changes After Spinal Cord Injury: Effects of Body Weight Supported Treadmill Training [PhD thesis]. Hamilton, ON: McMaster University; November 2004.
2016	Berman AG. Influence of Mechanical Stimulation on the Quantity and Quality of Bone During Modeling [Master's thesis]. Purdue University; August 2016.
2019	Powell KM. The Effects of Zoledronate and Raloxifene Combination Therapy on Diseased Mouse Bone [Master's thesis]. Indianapolis, IN: Purdue University; May 2019.
2016	Vrahna C. Investigating the Effects of Downstream Parathyroid Hormone (PTH) Targets on Bone Strength and Quality [PhD thesis]. Melbourne, Australia: The University of Melbourne; December 2016.