Multilineage potential of adult human mesenchymal stem cells

Pittenger, Mark F.<sup>1</sup>; Mackay, Alastair M.<sup>1</sup>; Beck, Stephen C.<sup>1</sup>; Jaiswal, Rama K.<sup>1</sup>; Douglas, Robin<sup>1</sup>; Mosca, Joseph D.<sup>1</sup>; Moorman, Mark A.<sup>1</sup>; Simonetti, Donald W.<sup>1</sup>; Craig, Stewart<sup>1</sup>; Marshak, Daniel R.<sup>1,2</sup>

Year	Entry
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2003	Simmons CA, Matlis S, Thornton AJ, Chen S, Wang C-Y, Mooney DJ. Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. J Biomech. August 2003;36(8):1087-1096.
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2022	De Kinderen P, Meester J, Loeys B, Peeters S, Gouze E, Woods S, Mortier G, Verstraeten A. Differentiation of induced pluripotent stem cells into chondrocytes: methods and applications for disease modeling and drug discovery. J Bone Miner Res. March 2022;37(3):397-410.
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2022	Ebert R, Weissenberger M, Braun C, Wagenbrenner M, Herrmann M, Müller-Deubert S, Krug M, Jakob F, Rudert M. Impaired regenerative capacity and senescence-associated secretory phenotype in mesenchymal stromal cells from samples of patients with aseptic joint arthroplasty loosening. J Orthop Res. February 2022;40(2):513-523.
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2016	Beane OS. The Effects of Aging and Chemotherapeutics on Mesenchymal Stem Cell Regenerative Properties [PhD thesis]. Brown University; May 2016.
2017	Marble HD. Gene Expression-Based Identification and Isolation of Cellular Subpopulations [PhD thesis]. Brown University; May 2017.
2019	Sutermaster BA. Investigations in Cell Sorting Techniques [PhD thesis]. Brown University; May 2019.
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2003	Mauck RL. Functional Tissue Engineering of Articular Cartilage: The Effect of Physical Forces on the in Vitro Growth of Engineered Constructs [PhD thesis]. Columbia University; 2003.
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2008	Estes BT. Functional Tissue Engineering of Cartilage Using Adipose-Derived Stem Cells [PhD thesis]. Duke University; 2008.
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2016	Glass KA. Combined Gene Therapy and Functional Tissue Engineering for the Treatment of Osteoarthritis [PhD thesis]. Duke University; 2016.
2016	Juhas ME. Engineering Highly-Functional, Self-Regenerative Skeletal Muscle Tissues With Enhanced Vascularization and Survival in Vivo [PhD thesis]. Duke University; 2016.
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2005	Case ND. Oscillatory Compressive Loading Effects on Mesenchymal Progenitor Cells Undergoing Chondrogenic Differentiation in Hydrogel Suspension [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; May 2005.
2005	Mouw JK. Mechanoregulation of Chondrocytes and Chondroprogenitors: The Role of TGF-Β and SMAD Signaling [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2005.
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2009	Wojtowicz AM. Genetically-Engineered Bone Marrow Stromal Cells and Collagen Mimetic Scaffold Modification for Healing Critically-Sized Bone Defects [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2009.
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2019	Ilas DC. The Role of Mesenchymal Stem Cells and Osteocytes in Subchondral Bone Changes in Hip Osteoarthritis [PhD thesis]. University of Leeds; May 2019.
2003	Chan GK. Delineation of Regulatory Factors and Mechanisms That Govern the Differentiation of Mesenchymal Cells to the Osteoblastic Lineage [PhD thesis]. McGill University; June 2003.
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2013	Khayat G. Low Frequency Stimulation of Stem Cells in Dynamic Culture Modulates Differentiation Pathways [PhD thesis]. McGill University; July 2013.
2013	Vernon LL. Articular Cartilage Response Following Impact Injury [PhD thesis]. University of Miami; August 2013.
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1999	Awad HA. Mesenchymal Stem Cell Seeded Collagen Scaffolds for Tendon Repair [PhD thesis]. University of Cincinnati; 1999.
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2008	Weaver AS. The Effect of Mechanical Stimulation on Bone Fracture Healing: Changes in Callus Morphology and Mesenchymal Stem Cell Homing [PhD thesis]. University of Michigan; 2008.
2018	Wu B. Development of Self-Regulatory Gene Circuits for Cartilage Tissue Engineering [PhD thesis]. University of Michigan; 2018.
2007	Wu Y-L. Interaction of Bone Cells With Biomimetic Hydroxyapatite Gelatin Nanocomposites Towards Developing Bone Tissue Engineering [PhD thesis]. University of Minnesota; December 2007.
2014	O’Conor CJ. TRPV4-Mediated Mechanotransduction in Articular Cartilage Function and Disease [PhD thesis]. University of North Carolina at Chapel Hill; 2014.
2011	Thaler R. The Effect of the Lathyrogens Beta-Aminopropionitril and Homocysteine on Osteoblastic Differentiation in Regard to Collagen Matrix Formation and Epigenetic Regulation of Gene Expression [PhD thesis]. University of Vienna; June 2011.
2013	Blaber EA. Stem Cell-Based Tissue Regeneration in Space [PhD thesis]. University of New South Wales; November 2013.
2010	Baker BM. Meniscus Tissue Engineering With Nanofibrous Scaffolds [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2010.
2010	Huang AH. Enhancing Mesenchymal Stem Cell Chondrogenesis for Cartilage Tissue Engineering [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2010.
2010	Nerurkar NL. Integrating Theoretical and Experimental Methods for Multi-Scale Tissue Engineering of the Annulus Fibrosus of the Intervertebral Dis [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2010.
2011	Erickson IE. Optimization and Translation of MSC-Based Hyaluronic Acid Hydrogels for Cartilage Repair [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2011.
2011	Silverman LI. Enhancing Meniscus Repair Through Biomaterial Design [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2011.
2013	Farrell MJ. Cartilage Tissue Engineering With Heterogeneous and Clonal Mesenchymal Stem Cell Populations: Multi-Scale Analysis of Maturation, Stability, and Response to Environmental Stressors [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2013.
2015	Driscoll TP. Nuclear Connectivity in Mesenchymal Stem Cell Differentiation and Its Role in Mechanotransduction [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2015.
2015	Heo SC. Differentiation Induces Dynamic Alterations in Mesenchymal Stem Cell Nuclear Architecture and Mechanotransduction [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2015.
2017	Kim M. Multi-Cellular and Multi-Scale Approaches for Cartilage Repair [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2017.
2017	McLeod CM. Single Cell Molecular Heterogeneity in Musculoskeletal Differentiation [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2017.
2017	Mohanraj B. High Throughput and Mechano-Active Platforms to Promote Cartilage Regeneration and Repair [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2017.
2008	Moss IL. Modified-Hyaluronan and Elastin-Like Polypeptide Composite Material for Tissue Engineering of the Nucleus Pulposus [Master's thesis]. University of Toronto; 2008.
2013	Liu CC. Effects of a New Conjugate Drug in a Rat Model of Postmenopausal Osteoporosis [Master's thesis]. University of Toronto; 2013.
2018	Zhang L. Effects of Osteoblast-Specific Gα_S Overexpression on Skeletal Development and Response to Catabolic and Anabolic Stimuli Using a Transgenic Mouse Model [PhD thesis]. University of Toronto; 2018.
2013	Manning CN. Anti-Inflammatory Effect of Adipose-Derived Mesenchymal Stem Cells for Flexor Tendon Healing [PhD thesis]. St. Louis, MO: Washington University in St. Louis; August 2013.
2020	Ross A. Tissue Engineering of Induced Pluripotent Stem Cells for the Development of Novel Treatment Strategies for Osteoarthritis [PhD thesis]. St. Louis, MO: Washington University in St. Louis; May 2020.

Year	Entry
1998	Johnstone B, Hering TM, Caplan AI, Goldberg VM, Yoo JU. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res. January 10, 1998;238(1):265-272.
1998	Mackay AM, Beck SC, Murphy JM, Barry FP, Chichester CO, Pittenger MF. Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow. Tissue Eng. Winter 1998;4(4):415-428.