Targeted and nontargeted bone remodeling:​ relationship to basic multicellular unit origination and progression

Parfitt, A. M.

Affiliations

¹Division of Endocrinology and Center for Osteoporosis and Metabolic Bone Disease, University of Arkansas for Medical Sciences, Little Rock, AR, USA

Links

DOI: 10.1016/S8756-3282(01)00642-1

PubMed: 11792557

WoS: 000173536900002

History

Received: 2001-04-02

Revised: 2001-06-15

Accepted: 2001-07-27

Cited Works (10)

Year	Entry
1997	Han Z-H, Palnitkar S, Rao DS, Nelson D, Parfitt AM. Effects of ethnicity and age or menopause on the remodeling and turnover of iliac bone: implications for mechanisms of bone loss. J Bone Miner Res. April 1997;12(4):498-508.
1994	Parfitt AM. Osteonal and hemi‐osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone. J Cell Biochem. July 1994;55(3):273-286.
1996	Parfitt AM, Mundy GR, Roodman GD, Hughes DE, Boyce BF. A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates. J Bone Miner Res. February 1996;11(2):150-159.
1976	Parfitt AM. The actions of parathyroid hormone on bone: relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone disease: part I of IV parts: mechanisms of calcium transfer between blood and bone and their cellular basis: morphological and kinetic approaches to bone turnover. Metabolism. July 1976;25(7):809-844.
1988	Peck WA, Woods W. The cells of bone. In: Riggs BL, Melton LJ III, eds. Osteoporosis: Etiology, Diagnosis, and Management. New York, NY: Raven Press; 1988:1-44.
1984	Currey JD. Mechanical Adaptations of Bone. Princeton, NJ: Princeton University Press; 1984.
1987	Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR. Bone histomorphometry: standardization of nomenclature, symbols, and units: report of the ASBMR histomorphometry nomenclature committee. J Bone Miner Res. December 1987;2(6):595-610.
1992	Lanyon LE. The success and failure of the adaptive response to functional load-bearing in averting bone fracture. Bone. 1992;13(2):S17-S21.
2000	Parfitt AM, Travers R, Rauch F, Glorieux FH. Structural and cellular changes during bone growth in healthy children. Bone. October 2000;27(4):487-494.
1969	Frost HM. Tetracycline-based histological analysis of bone remodeling. Calcif Tiss Res. 1969;3(1):211-237.

Cited By (53)

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2025	Allen MR, Wallace J. Skeletal Tissue Mechanics. 3rd ed. Cham, Switzerland: Springer; 2025.
2011	Feng X, McDonald JM. Disorders of bone remodeling. Annu Rev Pathol. 2011;6:121-145.
2002	Fazzalari NL, Kuliwaba JS, Forwood MR. Cancellous bone microdamage in the proximal femur: influence of age and osteoarthritis on damage morphology and regional distribution. Bone. December 2002;31(6):697-702.
2007	Martin RB. Targeted bone remodeling involves BMU steering as well as activation. Bone. June 2007;40(6):1574-1580.
2019	Burr DB. Stress concentrations and bone microdamage: John Currey's contributions to understanding the initiation and arrest of cracks in bone. Bone. October 2019;127:517-525.
2003	Martin RB. Fatigue microdamage as an essential element of bone mechanics and biology. Calcif Tiss Int. August 2003;73(2):101-107.
2014	Bellido T. Osteocyte-driven bone remodeling. Calcif Tiss Int. January 2014;94(1):25-34.
2007	Tatsumi S, Ishii K, Amizuka N, Li M, Kobayashi T, Kohno K, Ito M, Takeshita S, Ikeda K. Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Cell Metab. June 2007;5(6):464-475.
2008	Clarke B. Normal bone anatomy and physiology. Clin J Am Soc Nephrol. November 2008;3(suppl 3):S131-S139.
2019	Palepu V, Rayaprolu SD, Nagaraja S. Differences in trabecular bone, cortical shell, and endplate microstructure across the lumbar spine. Int J Spine Surg. 2019;13(4):361-370.
2016	Maggiano IS, Maggiano CM, Clement JG, Thomas CDL, Carter Y, Cooper DML. Three‐dimensional reconstruction of Haversian systems in human cortical bone using synchrotron radiation‐based micro‐CT: morphology and quantification of branching and transverse connections across age. J Anat. May 2016;228(5):719-732.
2015	Oftadeh R, Perez-Viloria M, Villa-Camacho JC, Vaziri A, Nazarian A. Biomechanics and mechanobiology of trabecular bone: a review. J Biomech Eng. January 2015;137(1):010802.
2005	Riggs BL, Parfitt AM. Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodeling. J Bone Miner Res. February 2005;20(2):177-184.
2006	Aguirre JI, Plotkin LI, Stewart SA, Weinstein RS, Parfitt AM, Manolagas SC, Bellido T. Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss. J Bone Miner Res. April 2006;21(4):605-615.
2006	Hernandez CJ, Gupta A, Keaveny TM. A biomechanical analysis of the effects of resorption cavities on cancellous bone strength. J Bone Miner Res. August 2006;21(8):1248-1255.
2010	Shane E, Burr D, Ebeling PR, Abrahamsen B, Adler RA, Brown TD, Cheung AM, Cosman F, Curtis JR, Dell R, Dempster D, Einhorn TA, Genant HK, Geusens P, Klaushofer K, Koval K, Lane JM, McKiernan F, McKinney R, Ng A, Nieves J, O'Keefe R, Papapoulos S, Sen HT, van der Meulen MCH, Weinstein RS, Whyte M. Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res. November 2010;25(11):2267-2294.
2022	Harrison KD, Sales E, Hiebert BD, Panahifar A, Zhu N, Arnason T, Swekla KJ, Pivonka P, Chapman LD, Cooper DML. Direct assessment of rabbit cortical bone basic multicellular unit longitudinal erosion rate: a 4D synchrotron-based approach. J Bone Miner Res. November 2022;37(11):2244-2258.
2021	Zendeli A, Bui M, Fischer L, Ghasem-Zadeh A, Schima W, Seeman E. High cortico-trabecular transitional zone porosity and reduced trabecular density in men and women with stress fractures. J Clin Med. March 8, 2021;10(5):1123.
2011	Xiong J, Onal M, Jilka RL, Weinstein RS, Manolagas SC, O'Brien CA. Matrix-embedded cells control osteoclast formation. Nat Med. November 2011;17(10):1235-1242.
2003	Bouxsein ML. Bone quality: where do we go from here? Osteoporos Int. September 2003;14(suppl 5):S118-S127.
2013	Schulte FA, Ruffoni D, Lambers FM, Christen D, Webster DJ, Kuhn G, Müller R. Local mechanical stimuli regulate bone formation and resorption in mice at the tissue level. PLoS One. April 2013;8(4):e62172.
2004	Pearson OM, Lieberman DE. The aging of Wolff's “law”: ontogeny and responses to mechanical loading in cortical bone. Yearb Phys Anthropol. 2004;47:63-99.
2020	Aggleton J. First-Hand Experience: A Methodology for Exploring Bone Architecture [PhD thesis]. Bristol, UK: University of Bristol; January 2020.
2012	Moayyeri A. Risk Assessment for Osteoporotic Fractures Among Men and Women from a Prospective Population Study: The EPIC-Norfolk Study [PhD thesis]. Cambridge, UK: University of Cambridge; 2012.
2017	Yu Y. Contributions of Anisotropic and Heterogeneous Tissue Modulus to Apparent Trabecular Bone Mechanical Properties [PhD thesis]. Columbia University; 2017.
2004	Samuel SP. Fluid/solid Interactions in Cancellous Bone [PhD thesis]. Cleveland State University; August 2004.
2020	Josephson TO. A Microstructural Analysis of the Mechanical Behavior of Cortical Bone Through Histology and Image Processing [Master's thesis]. Drexel University; June 2020.
2007	Voide R. Functional Phenotyping of Bone: A Hierarchical Assessment of Bone Failure Characteristics [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2007.
2016	Li Z. Time-Lapsed in Vivo Bone Response to Implantation in a Mouse Model of Disease and Treatment [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2016.
2024	Griesbach JK. Mechanobiology and Mineralization Dynamics in Bone Health and Disease: Insights from Computational Modeling, Organotypic Models, and in Vivo Studies [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2024.
2023	Nilsson K. NOTUM and RSPO3 in Bone: WNT Signaling Modulators Regulating the Skeleton [PhD thesis]. University of Gothenburg; 2023.
2006	Main RP. Skeletal Mechanics, Bone Histomorphology, and Growth in Tetrapods [PhD thesis]. Cambridge, MA: Harvard University; September 2006.
2015	Oftadeh R. Hierarchical Analysis and Multiscale Modelling of Cellular Structures: From Meta Materials to Bone Structure [PhD thesis]. Northeastern University; December 2015.
2004	Wang X. Measurement and Analysis of Microdamage in Bone [PhD thesis]. University of Notre Dame; December 2004.
2010	Shi X. Effects of Architecture on Microdamage Susceptibility in Trabecular Bone [PhD thesis]. University of Notre Dame; April 2010.
2011	Garrison JG. The Relative Importance of Stress State, Microarchitecture, and Damage Burden in the Failure Behavior of Trabecular Bone [PhD thesis]. University of Notre Dame; April 2011.
2011	Agnew AM. Histomorphometry of the Elderly Rib: A Methodological Approach With Implications for Biomechanics, Function, and Fracture Risk [PhD thesis]. The Ohio State University; 2011.
2015	Hunter RL. Variation in Cortical Osteocyte Lacunar Density and Distribution: Implications for Bone Quality Assessment [PhD thesis]. The Ohio State University; 2015.
2018	Dominguez VM. Defining Bone Quality: Cortical Microdamage and Its Contribution to Fracture Risk in the Human Rib [PhD thesis]. The Ohio State University; 2018.
2017	Owen R. Tissue Engineering an in Vitro Model of Osteoporosis [PhD thesis]. Sheffield, UK: University of Sheffield; October 2017.
2011	Wulliamoz PM. Micromechanical Modelling of Normal, Drug Treated and Osteoporotic Bone Using Scanning Acoustic Microsopy and Finite Element Analysis [PhD thesis]. Trinity College Dublin; December 2011.
2012	Nishiyama KKS. In Vivo Assessment of Bone Microarchitecture and Estimated Bone Strength [PhD thesis]. Calgary, AB: University of Calgary; October 2012.
2017	Fung A. Experimental Validation of Finite Element Predicted Bone Strain in the Human Metatarsal [Master's thesis]. Calgary, AB: University of Calgary; April 2017.
2019	Kroker AM. The Progression of Bone Microarchitecture Changes Following an Acute Knee Injury in Young Adults [PhD thesis]. Calgary, AB: University of Calgary; March 2019.
2020	Plett RM. Enhanced Longitudinal Analysis of Bone Strength Estimated by 3D Bone Imaging and the Finite Element Method [Master's thesis]. Calgary, AB: University of Calgary; October 2020.
2010	Melhus G. Molecular Studies on Bone With Focus on Fracture Healing in Experimental Osteoporosis [PhD thesis]. Oslo, Norway: University of Oslo; 2010.
2024	Qalaj P. Finite Element Analysis of Nanoindentation Across Bone Interfaces and Effects on the Measured Mechanical Properties [Master's thesis]. Liège, Belgique: Université de Liège; 2024.
2019	Surowiec R. Novel Models to Image and Quantify Bone Drug Efficacy and Disease Progression in Vivo: Addressing the Fragility Phenotype [PhD thesis]. University of Michigan; 2019.
2010	Hughes JM. Revisiting Harold Frost's Mechanostat Theory of Bone Functional Adaptation: New Interpretations Based on New Evidence [PhD thesis]. University of Minnesota; December 2010.
2003	Rüberg T. Computer Simulation of Adaptive Bone Remodeling [Master's thesis]. Universidad de Zaragoza; 2003.
2021	Harrison KD. A Novel in Vivo Synchrotron Radiation Micro-CT Imaging Platform for the Direct Tracking of Remodeling Events in Cortical Bone [PhD thesis]. University of Saskatchewan; December 2021.
2017	Gooding AF. Variation in Cortical Bone Distribution in the Aging Adult Appendicular Skeleton [PhD thesis]. Knoxville, University of Tennessee; December 2017.
2007	McDonald MM. The Role of the Osteoclast During Endochondral Ossification in a Rat Fracture Model [PhD thesis]. University of Technology Sydney (UTS); May 2007.