Standardized nomenclature, symbols, and units for bone histomorphometry:​ a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

Dempster, David W.; Compston, Juliet E.; Drezner, Marc K.; Glorieux, Francis H.; Kanis, John A.; Malluche, Hartmut; Meunier, Pierre J.; Ott, Susan M.; Recker, Robert R.; Parfitt, A. Michael

Year	Entry
2019	Zenzes M, Bortel EL, Fratzl P, Mundlos S, Schuetz M, Schmidt H, Duda GN, Witte F, Zaslansky P. Normal trabecular vertebral bone is formed via rapid transformation of mineralized spicules: a high-resolution 3D ex-vivo murine study. Acta Biomater. March 1, 2019;86:429-440.
2014	Andersen TL, Hauge EM, Rolighed L, Bollerslev J, Kjærsgaard-Andersen P, Delaisse J-M. Correlation between absence of bone remodeling compartment canopies, reversal phase arrest, and deficient bone formation in post-menopausal osteoporosis. Am J Pathol. April 2014;184(4):1142-1151.
2015	Jensen PR, Andersen TL, Hauge E-M, Bollerslev J, Delaissé J-M. A joined role of canopy and reversal cells in bone remodeling: lessons from glucocorticoid-induced osteoporosis. Bone. April 2015;73:16-23.
2016	Meyer LA, Johnson MG, Cullen DM, Vivanco JF, Blank RD, Ploeg H-L, Smith EL. Combined exposure to big endothelin-1 and mechanical loading in bovine sternal cores promotes osteogenesis. Bone. April 2016;85:115-122.
2018	Andreasen CM, Delaisse J-M, van der Eerden BCJ, van Leeuwen JPTM, Ding M, Andersen TL. Understanding age-induced cortical porosity in women: is a negative BMU balance in quiescent osteons a major contributor? Bone. December 2018;117:70-82.
2020	Mulati M, Kobayashi Y, Takahashi A, Numata H, Saito M, Hiraoka Y, Ochi H, Sato S, Ezura Y, Yuasa M, Hirai T, Yoshii T, Okawa A, Inose H. The long noncoding RNA Crnde regulates osteoblast proliferation through the Wnt/β-catenin signaling pathway in mice. Bone. January 2020;130:115076.
2020	Yorgan TA, Sari H, Rolvien T, Windhorst S, Failla AV, Kornak U, Oheim R, Amling M, Schinke T. Mice lacking plastin-3 display a specific defect of cortical bone acquisition. Bone. January 2020;130:115062.
2020	Surowiec RK, Battle LF, Ward FS, Schlecht SH, Khoury BM, Robbins C, Wojtys EM, Caird MS, Kozlof KM. A xenograft model to evaluate the bone forming effects of sclerostin antibody in human bone derived from pediatric osteogenesis imperfecta patients. Bone. January 2020;130:115118.
2020	Rossi M, Buonuomo PS, Battafarano G, Conforti A, Mariani E, Algeri M, Pelle S, D’Agostini M, Macchiaiolo M, De Vito R, Gonfiantini MV, Jenkner A, Rana I, Bartuli A, Del Fattore A. Dissecting the mechanisms of bone loss in Gorham-Stout disease. Bone. January 2020;130:115068.
2020	Sørensen TG, Brent MB, Thomsen JS, Brüel A. Disuse-induced loss of bone mineral density and bone strength is attenuated by post-lactational bone gain in NMRI mice. Bone. January 2020;130:115183.
2020	Li H, Jing Y, Zhang R, Zhang Q, Wang J, Martine A, Feng JQ. Hypophosphatemic rickets accelerate chondrogenesis and cell trans-differentiation from TMJ chondrocytes into bone cells via a sharp increase in β-catenin. Bone. February 2020;131.
2020	Xiao H, Xie X, Wen Y, Tan Y, Shangguan Y, Li B, Magdalou J, Wang H, Chen L. Subchondral bone dysplasia partly participates in prenatal dexamethasone induced-osteoarthritis susceptibility in female offspring rats. Bone. April 2020;133:115245.
2020	Aaltonen L, Koivuviita N, Seppänen M, Tong X, Kröger H, Löyttyniemi E, Metsärinne K. Correlation between ¹⁸F-Sodium Fluoride positron emission tomography and bone histomorphometry in dialysis patients. Bone. May 2020;134:115267.
2020	Jandl NM, von Kroge S, Stürznickel J, Baranowsky A, Stockhausen KE, Mushumba H, Beil FT, Püschel K, Amling M, Rolvien T. Large osteocyte lacunae in iliac crest infantile bone are not associated with impaired mineral distribution or signs of osteocytic osteolysis. Bone. June 2020;135:115324.
2020	Hirose K, Ishimoto T, Usami Y, Sato S, Oya K, Nakano T, Komori T, Toyosawa S. Overexpression of Fam20C in osteoblast in vivo leads to increased cortical bone formation and osteoclastic bone resorption. Bone. September 2020;138:115414.
2020	Wölfel EM, Jähn-Rickert K, Schmidt FN, Wulff B, Mushumba H, Sroga GE, Püschel K, Milovanovic P, Amling M, Campbell GM, Vashishth D, Busse B. Individuals with type 2 diabetes mellitus show dimorphic and heterogeneous patterns of loss in femoral bone quality. Bone. November 2020;140:115556.
2020	Albiol L, Büttner A, Pflanz D, Mikolajewicz N, Birkhold AI, Kramer I, Kneissel M, Duda GN, Checa S, Willie BM. Effects of long-term sclerostin deficiency on trabecular bone mass and adaption to limb loading differ in male and female mice. Calcif Tiss Int. April 2020;106(4):415-430.
2020	Cardinal M, Dessain A, Roels T, Lafont S, Ominsky MS, Devogelaer J-P, Chappard D, Mabilleau G, Ammann P, Nyssen-Behets C, Manicourt DH. Sclerostin-antibody treatment decreases fracture rates in axial skeleton and improves the skeletal phenotype in growing oim/oim mice. Calcif Tiss Int. May 2020;106(5):494-508.
2020	Williams EAJ, Douard V, Sugimoto K, Inui H, Devime F, Zhang X, Kishida K, Ferraris RP, Fritton JC. Bone growth is influenced by fructose in adolescent male mice lacking ketohexokinase (KHK). Calcif Tiss Int. May 2020;106(5):541-552.
2015	Maquer G, Musy SN, Wandel J, Gross T, Zysset PK. Bone volume fraction and fabric anisotropy are better determinants of trabecular bone stiffness than other morphological variables. J Bone Miner Res. June 2015;30(6):1000-1008.
2017	Lassen NE, Andersen TL, Pløen GG, Søe K, Hauge EM, Harving S, Eschen GET, Delaisse J-M. Coupling of bone resorption and formation in real time: new knowledge gained from human Haversian BMUs. J Bone Miner Res. July 2017;32(7):1395-1405.
2019	Li Y, Shi Z, Jules J, Chen S, Kesterson RA, Zhao D, Zhang P, Feng X. Specific RANK cytoplasmic motifs drive osteoclastogenesis. J Bone Miner Res. October 2019;34(10):1938-1951.
2019	Bullock WA, Hoggatt AM, Horan DJ, Lewis KJ, Yokota H, Hann S, Warman ML, Sebastian A, Loots GG, Pavalko FM, Robling AG. Expression of a degradation‐resistant β‐catenin mutant in osteocytes protects the skeleton from mechanodeprivation‐induced bone wasting. J Bone Miner Res. October 2019;34(10):1964-1975.
2020	Cheng Z, Li A, Tu C, Santa Maria C, Szeto N, Herberger A, Chen T, Song F, Wang J, Liu X, Shoback DM, Chang W. Calcium‐sensing receptors in chondrocytes and osteoblasts are required for callus maturation and fracture healing in mice. J Bone Miner Res. January 2020;35(1):143-154.
2020	Noda H, Guo J, Khatri A, Dean T, Reyes M, Armanini M, Brooks DJ, Martins JS, Schipani E, Bouxsein ML, Demay MB, Potts JT Jr, Jüppner H, Gardella TJ. An inverse agonist ligand of the PTH receptor partially rescues skeletal defects in a mouse model of Jansen's metaphyseal chondrodysplasia. J Bone Miner Res. March 2020;35(3):540-549.
2020	Chen NX, Srinivasan S, O'Neill K, Nickolas TL, Wallace JM, Allen MR, Metzger CE, Creecy A, Avin KG, Moe SM. Effect of advanced glycation end‐products (AGE) lowering drug ALT‐711 on biochemical, vascular, and bone parameters in a rat model of CKD‐MBD. J Bone Miner Res. March 2020;35(3):608-617.
2020	Henaff CL, Ricarte F, Finnie B, He Z, Johnson J, Warshaw J, Kolupaeva V, Partridge NC. Abaloparatide at the same dose has the same effects on bone as PTH (1‐34) in mice. J Bone Miner Res. April 2020;35(4):714-724.
2020	Li H, Sun H, Qian B, Feng W, Carney D, Miller J, Hogan MV, Wang L. Increased expression of FGF‐21 negatively affects bone homeostasis in dystrophin/utrophin double knockout mice. J Bone Miner Res. April 2020;35(4):738-752.
2020	Wang C, Xiao J, Nowak K, Gunasekera K, Alippe Y, Speckman S, Yang T, Kress D, Abu‐Amer Y, Hottiger MO, Mbalaviele G. PARP1 hinders histone H2B occupancy at the NFATc1 promoter to restrain osteoclast differentiation. J Bone Miner Res. April 2020;35(4):776-788.
2020	Shin B, Kupferman J, Schmidt E, Polleux F, Delany AM, Lee S. Rac1 inhibition via Srgap2 restrains inflammatory osteoclastogenesis and limits the clastokine, SLIT3. J Bone Miner Res. April 2020;35(4):789-800.
2020	Zhou Y, Yang Y, Jing Y, Yuan T, Sun L, Tao B, Liu J, Zhao H. BMP9 reduces bone loss in ovariectomized mice by dual regulation of bone remodeling. J Bone Miner Res. May 2020;35(5):978-993.
2020	Chandra A, Lagnado AB, Farr JN, Monroe DG, Park S, Hachfeld C, Tchkonia T, Kirkland JL, Khosla S, Passos JF, Pignolo RJ. Targeted reduction of senescent cell burden alleviates focal radiotherapy‐related bone loss. J Bone Miner Res. June 2020;35(6):1119-1131.
2020	Dempster DW, Chines A, Bostrom MP, Nieves JW, Zhou H, Chen L, Pannacciulli N, Wagman RB, Cosman F. Modeling‐based bone formation in the human femoral neck in subjects treated with denosumab. J Bone Miner Res. July 2020;35(7):1282-1288.
2020	Recker R, Dempster D, Langdahl B, Giezek H, Clark S, Ellis G, de Villiers T, Valter I, Zerbini CAF, Cohn D, Santora A, Duong LT. Effects of odanacatib on bone structure and quality in postmenopausal women with osteoporosis: 5‐year data from the Phase 3 Long‐term Odanacatib Fracture Trial (LOFT) and its extension. J Bone Miner Res. 2020;35(7):1289-1299.
2019	Mondal A, Nguyen C, Ma X, Elbanna AE, Carlson JM. Network models for characterization of trabecular bone. Phys Rev E. April 18, 2019;99(4):042406.
2016	Torres AM, Matheny JB, Keaveny TM, Taylor D, Rimnac CM, Hernandez CJ. Material heterogeneity in cancellous bone promotes deformation recovery after mechanical failure. Proc Natl Acad Sci USA. March 15, 2016;113(11):2892-2897.
2020	Koide M, Yamashita T, Murakami K, Uehara S, Nakamura K, Nakamura M, Matsushita M, Ara T, Yasuda H, Penninger JM, Takahashi N, Udagawa N, Kobayashi Y. Sclerostin expression in trabecular bone is downregulated by osteoclasts. Sci Rep. 2020;10:13751.
2015	Nguyen AM. Multiscale Mechanobiology of Primary Cilia [PhD thesis]. Columbia University; 2015.
2018	Moore ER. The Primary Cilium Encourages Osteogenic Behavior in Periosteal Osteochondroprogenitors and Osteocytes During Juvenile Skeletal Development and Adult Bone Adaptation [PhD thesis]. Columbia University; 2018.
2015	Goff M. The Role of Micro and Ultra-Structure in Microdamage Accumulation in Cancellous Bone [PhD thesis]. Ithaca, NY: Cornell University; August 2015.
2017	Cresswell EN. Spatial Regulation of Bone Formation in Functional Adaptation of Cancellous Bone [PhD thesis]. Ithaca, NY: Cornell University; May 2017.
2017	Matheny JB. Interactions Between Bone Remodeling and Microdamage in Cancellous Bone [PhD thesis]. Ithaca, NY: Cornell University; August 2017.
2018	Torres AM. Fatigue Behavior of Cancellous Bone, Microdamage Accumulation, and Biologically Inspired Cellular Solids [PhD thesis]. Ithaca, NY: Cornell University; August 2018.
2019	Bullock WA. The Role of Wnt Signaling in Bone Mechanotransduction [PhD thesis]. Indianapolis, IN: Indiana University – Purdue University Indianapolis; November 2019.
2019	Davis HM. Molecular Mechanisms Underlying Osteocyte Apoptosis and the Associated Osteoclastogenesis in Cx43-Deficiency and Aging [PhD thesis]. Indiana University – Purdue University Indianapolis (IUPUI); June 2019.
2015	Clauser CA. In Vivo Tibial Loading of Healthy and Osteolathrytic Mice [Master's thesis]. Indianapolis, IN: Purdue University; May 2015.
2016	Hammond MA. The Influence of Collagen Crosslinking and Treadmill Exercise on the Mechanics, Composition, and Morphology of Bone At Multiple Length Scales [PhD thesis]. Purdue University; May 2016.
2016	Yee CSN. Determining the Role of Sost and Sostdc1 During Fracture Healing [PhD thesis]. Merced, CA: Merced, University of California; 2016.
2019	Nguyen C. Multiscale Network Characterization of the Strength and Robustness of Trabecular Bone [PhD thesis]. Santa Barbara, CA: Santa Barbara, University of California; September 2019.
2019	Mazur C. Osteocyte Regulation of Bone Quality in Homeostasis and in Skeletal Disease [PhD thesis]. San Francisco (UCSF), University of California; 2019.
2019	Poon A. Pamidronate Does Not Affect Cortical Porosity in Transgenic Mice Overexpressing Osteoblastic Gαs [Master's thesis]. University of Toronto; 2019.
2019	Putnam NE. Innate Immunity and Bone Remodeling During Staphylococcus Aureus Osteomyelitis [PhD thesis]. Nashville, TN: Vanderbilt University; June 30, 2019.
2016	Johnson MG. Endothelin-Converting Enzyme-1 Dependent Endothelin 1 Signaling in Osteogenesis [PhD thesis]. Madison, WI: University of Wisconsin; 2016.
2013	Tomlinson RE. The Role of Angiogenesis in Osteogenic Mechanical Loading [PhD thesis]. St. Louis, MO: Washington University in St. Louis; May 2013.

Year	Entry
1986	Eriksen EF. Normal and pathological remodeling of human trabecular bone: three dimensional reconstruction of the remodeling sequence in normals and in metabolic bone disease. Endocr Rev. November 1986;7(4):379-408.
1984	Parfitt AM. The cellular basis of bone remodeling: the quantum concept reexamined in light of recent advances in the cell biology of bone. Calcif Tiss Int. March 1984;36(suppl 1):S37-S45.
1986	Garrahan NJ, Mellish RWE, Compston JE. A new method for the two-dimensional analysis of bone structure in human iliac crest biopsies. J Microsc (Oxford). June 1986;142(3):341-349.
1978	Singh I. The architecture of cancellous bone. J Anat. October 1978;127(2):305-310.
1995	Dobnig H, Turner RT. Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells. Endocrinology. August 1995;136(8):3632-3638.
1969	Frost HM. Tetracycline-based histological analysis of bone remodeling. Calcif Tiss Res. 1969;3(1):211-237.
2008	Roschger P, Paschalis EP, Fratzl P, Klaushofer K. Bone mineralization density distribution in health and disease. Bone. March 2008;42(3):456-466.
1966	Arnold JS, Bartley MH, Tont SA, Jenkins DP. Skeletal changes in aging and disease. Clin Orthop Relat Res. December 1966;49:17-38.
1974	Whitehouse WJ. The quantitative morphology of anisotropic trabecular bone. J Microsc (Oxford). July 1974;101:153-168.
1977	Whitehouse WJ. Cancellous bone in the anterior part of the iliac crest. Calcif Tiss Res. December 1977;23(1):67-76.
1995	Boyce RW, Ebert DC, Youngs TA, Paddock CL, Mosekilde L, Stevens ML, Gundersen HJG. Unbiased estimation of vertebral trabecular connectivity in calcium-restricted ovariectomized minipigs. Bone. June 1995;16(6):637-642.
1982	Kragstrup J, Gundersen HJG, Melsen F, Mosekilde L. Estimation of the three-dimensional wall thickness of completed remodeling sites in iliac trabecular bone. Metab Bone Dis Rel Res. 1982;4(2):113-119.
1978	Carter DR, Spengler DM. Mechanical properties and composition of cortical bone. Clin Orthop Relat Res. September 1978;135:192-217.
1983	Parfitt AM, Mathews CH, Villanueva AR, Kleerekoper M, Frame B, Rao DS. Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis: implications for the microanatomic and cellular mechanisms of bone loss. J Clin Invest. October 1983;72(4):1396-1409.
1984	Keshawarz NM, Recker RR. Expansion of the medullary cavity at the expense of cortex in postmenopausal osteoporosis. Metab Bone Dis Rel Res. 1984;5(5):223-228.
2010	Zebaze RMD, Ghasem-Zadeh A, Bohte A, Iuliano-Burns S, Mirams M, Price RI, Mackie EJ, Seeman E. Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study. Lancet. May 15, 2010;375(9727):1729-1736.
1987	Compston JE, Mellish RWE, Garrahan NJ. Age-related changes in iliac crest trabecular microanatomic bone structure in man. Bone. 1987;8(5):289-292.
1987	Weinstein RS, Hutson MS. Decreased trabecular width and increased trabecular spacing contribute to bone loss with aging. Bone. 1987;8(3):137-142.
1970	Merz WA, Schenk RK. Quantitative structural analysis of human cancellous bone. Acta Anat. 1970;75(1):54-66.
1987	Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR. Bone histomorphometry: standardization of nomenclature, symbols, and units: report of the ASBMR histomorphometry nomenclature committee. J Bone Miner Res. 1987;2(6):595-610.
1986	Cowin SC. Wolff’s law of trabecular architecture at remodeling equilibrium. J Biomech Eng. February 1986;108(1):83-88.