This study investigated the response of the Global Human Body Models Consortium (GHBMC) M50- O v4.5 model in a simulated thoracic impact and compared to the responses of post-mortem human subjects (PMHS) in physical experiments. The model was simulated in four tissue states:​ intact, intact with upper limbs removed, denuded (superficial tissue removed), and eviscerated (superficial tissue and viscera removed). The GHBMC model was subjected to a 3 m/s frontal thoracic impact using a 23 kg impactor, with the model seated upright in a fixed-back configuration. Force-compression results from the simulations were compared directly to PMHS responses from the series of frontal impacts limited to ≤20% chest compression. Biofidelity of the GHBMC thorax responses were quantified using the NHTSA Biofidelity Ranking System (BioRank). Additionally, individual mid-level ribs from the GHBMC were extracted and simulated in the isolated rib bending test scenario. The forcedisplacement and fracture location were compared to the physical experiments on the same ribs. In the thoracic loading simulations, the GHBMC exhibited biofidelity scores of 1.6, 1.5, 2.4 and 1.6 in the intact, upper limbs removed, denuded and eviscerated conditions, respectively. The scores were deemed acceptable (BioRank<2.0) in three of four conditions. The individual rib simulations resulted in a peak force of approximately 150N at fracture. This fracture occurred when the effective plastic strain reached 1.8% and at a location closer to the vertebral end than the experiment. The force-displacement responses of the GHBMC ribs were similar to the experimental tests of the corresponding ribs.