How does antiresorptive therapy decrease the risk of fracture in women with osteoporosis?

Delmas, P. D.<sup>1</sup>

Affiliations

¹Claude Bernard University of Lyon, Lyon, France

Links

DOI: 10.1016/S8756-3282(00)00301-X

PubMed: 10865202

WoS: 000088377200001

History

Received: 2000-02-02

Accepted: 2000-02-28

Cited Works (7)

Year	Entry
1993	Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med. June 1993;94(6):646-650.
1999	Pols HAP, Felsenberg D, Hanley DA, Štepán J, Muñoz-Torres M, Wilkin TJ, Qin-sheng G, Galich AM, Vandormael K, Yates AJ, Stych B; Fosamax® International Trial Study Group. Multinational, placebo-controlled, randomized trial of the effects of alendronate on bone density and fracture risk in postmenopausal women with low bone mass: results of the FOSIT study. Osteoporos Int. April 1999;9(5):461-468.
1999	Harris ST, Watts NB, Genant HK, McKeever CD, Hangartner T, Keller M, Chesnut CH III, Brown J, Eriksen EF, Hoseyni MS, Axelrod DW, Miller PD; Vertebral Efficacy With Risedronate Therapy (VERT) Study Group. Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. JAMA. October 13, 1999;282(14):1344-1352.
1999	Ettinger B, Black DM, Mitlak BH, Knickerbocker RK, Nickelsen T, Genant HK, Christiansen C, Delmas PD, Zanchetta JR, Stakkestad J, Glüer CC, Krueger K, Cohen FJ, Eckert S, Ensrud KE, Avioli LV, Lips P, Cummings SR; Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. JAMA. August 18, 1999;282(7):637-645.
1996	Garnero P, Hausherr E, Chapuy M, Marcelli C, Grandjean H, Muller C, Cormier C, Bréart G, Meunier PJ, Delmas PD. Markers of bone resorption predict hip fracture in elderly women: the EPIDOS prospective study. J Bone Miner Res. October 1996;11(10):1531-1538.
1990	Riggs BL, Hodgson SF, O'Fallon WM, Chao EYS, Wahner HW, Muhs JM, Cedel SL, Melton LJ III. Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis. NEJM. March 22, 1990;322(12):802-809.
1998	Cummings SR, Black DM, Thompson DE, Applegate WB, Barrett-Connor E, Musliner TA, Palermo L, Prineas R, Rubin SM, Scott JC, Vogt T, Wallace R, Yates AJ, LaCroix AZ; Fracture Intervention Trial Research Group. Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial. JAMA. December 23, 1998;280(24):2077-2082.

Cited By (24)

Year	Entry
2001	Roschger P, Rinnerthaler S, Yates J, Rodan GA, Fratzl P, Klaushofer K. Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women. Bone. August 2001;29(2):185-191.
2004	Delmas PD, Seeman E. Changes in bone mineral density explain little of the reduction in vertebral or nonvertebral fracture risk with anti-resorptive therapy. Bone. April 2004;34(4):599-604.
2006	Allen MR, Iwata K, Phipps R, Burr DB. Alterations in canine vertebral bone turnover, microdamage accumulation, and biomechanical properties following 1-year treatment with clinical treatment doses of risedronate or alendronate. Bone. October 2006;39(4):872-879.
2009	Bevill G, Eswaran SK, Farahmand F, Keaveny TM. The influence of boundary conditions and loading mode on high-resolution finite element-computed trabecular tissue properties. Bone. April 2009;44(4):573-578.
2003	Dufresne TE, Chmielewski PA, Manhart MD, Johnson TD, Borah B. Risedronate preserves bone architecture in early postmenopausal women in 1 year as measured by three-dimensional microcomputed tomography. Calcif Tiss Int. November 2003;73(5):423-432.
2007	Eswaran SK, Allen MR, Burr DB, Keaveny TM. A computational assessment of the independent contribution of changes in canine trabecular bone volume fraction and microarchitecture to increased bone strength with suppression of bone turnover. J Biomech. 2007;40(15):3424-3431.
2009	Eswaran SK, Bevill G, Nagarathnam P, Allen MR, Burr DB, Keaveny TM. Effects of suppression of bone turnover on cortical and trabecular load sharing in the canine vertebral body. J Biomech. March 11, 2009;42(4):517-523.
2003	Eastell R, Barton I, Hannon R, Chines A, Garnero P, Delmas P. Relationship of early changes in bone resorption to the reduction in fracture risk with risedronate. J Bone Miner Res. June 2003;18(6):1051-1056.
2002	Hochberg MC, Greenspan S, Wasnich RD, Miller P, Thompson DE, Ross PD. Changes in bone density and turnover explain the reductions in incidence of nonvertebral fractures that occur during treatment with antiresorptive agents. J Clin Endocrinol Metab. April 2002;87(4):1586-1592.
2005	Boutroy S, Bouxsein ML, Munoz F, Delmas PD. In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab. December 2005;90(12):6508-6515.
2004	Day JS, Ding M, Bednarz P, van der Linden JC, Mashiba T, Hirano T, Johnston CC, Burr DB, Hvid I, Sumner DR, Weinans H. Bisphosphonate treatment affects trabecular bone apparent modulus through micro-architecture rather than matrix properties. J Orthop Res. May 2004;22(3):465-471.
2002	Delmas PD. Treatment of postmenopausal osteoporosis. Lancet. June 8, 2002;359(9322):2018-2026.
2006	Seeman E, Delmas PD. Bone quality: the material and structural basis of bone strength and fragility. NEJM. May 25, 2006;354(21):2250-2261.
2008	Allen MR, Gineyts E, Leeming DJ, Burr DB, Delmas PD. Bisphosphonates alter trabecular bone collagen cross-linking and isomerization in beagle dog vertebra. Osteoporos Int. March 2008;19(3):329-337.
2015	Zhou B. Bone Quality Assessment Using High Resolution Peripheral Quantitative Computed Tomography (HR-PQCT) [PhD thesis]. Columbia University; 2015.
2016	Wang J. Plate-Rod Microstructural Modeling for Accurate and Fast Assessment of Bone Strength [PhD thesis]. Columbia University; 2016.
2015	Brock GR Jr. Changes in Bone Tissue Properties With Osteoporosis Treatment [PhD thesis]. Ithaca, NY: Cornell University; January 2015.
2005	Day JS. Bone Quality: The Mechanical Effects of Microarchitecture and Matrix Properties [PhD thesis]. Erasmus University Rotterdam; 2005.
2009	Ruppel ME. Alterations in the Mineral and Collagen Matrix of Bisphosphonate-Treated Bone and Osteoblasts [PhD thesis]. Stony Brook, NY: Stony Brook University; May 2009.
2011	Patri N. Low Intensity Vibrations Applied Locally Can be Transmitted to the Alveolar Bone Thereby Enhancing the Quality of the Bone in Adults Rats [Master's thesis]. Stony Brook, NY: Stony Brook University; May 2011.
2013	Enns-Bray WS. Mapping Anisotropy of the Proximal Femur for Improved Image-Based Finite Element Analysis [Master's thesis]. Calgary, AB: University of Calgary; August 2013.
2008	Bevill GR. Micromechanical Modeling of Failure in Trabecular Bone [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2008.
2010	Fields AJ. Trabecular Microarchitecture, Endplate Failure, and the Biomechanics of Human Vertebral Fractures [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2010.
2019	Sadoughi S. Micromechanics of Human Bone: Role of Architecture and Tissue Material Properties [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2019.