National Highway Transport Safety Administration (NHTSA) has been investigating oblique offset frontal impact test conditions. This research developed a validated occupant interior and restraint systems that could be used to evaluate the kinematics and injury implications for frontal crash test conditions. The objective was to develop validated oblique offset crash simulations using both Test device for Human Occupant Restraint (THOR) dummy model and human body models. The vehicle selected for this Computer Aided Engineering (CAE) study was a 2014 Honda Accord. The vehicle interior was scanned and modeled and restraint characterization tests were conducted. The occupant interior finite element (FE) model was developed and validated against available test data. FE models for THOR dummies were seated in driver and passenger seats and validated against both left and right oblique offset test results. Subsequently, the 50th percentile FE Human body model from Global Human Body Models Consortium (GHBMC) was seated in the vehicle and the kinematics was compared against the THOR dummy model. The outcome of this study was to develop realistic FE models that could be used to investigate how crash test conditions can affect optimal occupant restraint system design. The results predicted from the CAE simulations of the baseline vehicle model demonstrated similar safety performance to the available vehicle test results in terms of vehicle acceleration and intrusion responses in NCAP frontal, IIHS moderate overlap, IIHS small overlap test procedures, and left and right NHTSA oblique frontal tests. The CAE simulation results compared well with test results for THOR dummy model accelerations and injury criteria. A comparison of occupant kinematics, belt loads and injury criteria against the simulations using the GHBMC model also was done. The CAE simulation results using the GHBMC also compared well with test and CAE results of using THOR dummy model.