Relations between tensile impact properties and microstructure of compact bone

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Saha, S.¹; Hayes, W. C.^2,3

Relations between tensile impact properties and microstructure of compact bone

Calcif Tiss Res. December 1977;24(1):65-72

©1977 Springer-Verlag

Affiliations

¹Department of Engineering and Applied Science, Yale University

²Department of Applied Mechanics, Stanford University, USA

³Present address: Department of Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Penn. 19174, USA
Abstract and keywords

Standardized human and beef femoral compact bone specimens were tested in tensile impact and the dynamic mechanical properties were determined. The microstructure of 45 beef and 47 human bone specimens were examined histologically to determine if there is a structural basis to account for strength differences in the bone samples. Strong negative correlations were obtained between the maximum stress and the percentage area of secondary osteons in each specimen. For human bone samples, the energy absorption capacity and the modulus of elasticity were also found to have strong negative correlations with the percentage area of secondary osteons present in each specimen. Linear regression equations were obtained describing the impact strength properties in terms of the percentage areas of secondary osteons and cavities in the samples.

Fracture surfaces of the tested bone specimens were examined in a scanning electron microscope. Most surfaces exhibited a fairly rough texture indicating a quasi-cleavage type of failure. Fractographic analysis of bone fracture surface was helpful in understanding the micromechanics of bone fracture.

Keywords: Bone; Strength; Tension; Microstructure; Osteon
Links

DOI: 10.1007/BF02223298

PubMed: 597746

WoS: A1977EE03200009
History

Received: 1976-08-23

Accepted: 1977-02-02

Cited Works (22)

Year	Entry
1974	Saha S, Hayes WC. Instrumented tensile-impact tests of bone. Exp Mech. December 1974;14(12):473-478.
1959	Currey JD. Differences in the tensile strength of bone of different histological types. J Anat. January 1959;93(1):87-95.
1963	Frost HM. Bone Remodelling Dynamics. Springfield, IL: Charles C. Thomas; 1963.
1968	Ascenzi A, Bonucci E. The compressive properties of single osteons. Anat Rec. July 1968;161(3):377-392.
1958	Evans FG. Relations between the microscopic structure and tensile strength of human bone. Acta Anat. 1958;35(4):285-301.
1952	Amprino R, Engström A. Studies on x-ray absorption and diffraction of bone tissue. Acta Anat. 1952;15(1-2):1-22.
1966	Sedlin‌ ED, Hirsch C. Factors affecting the determination of the physical properties of femoral cortical bone. Acta Orthop Scand. 1966;37(1):29-48.
1970	Piekarski K. Fracture of bone. J Appl Phys. January 1970;41(1):215-223.
1957	Evans FG. Stress and Strain in Bones: Their Relation to Fractures and Osteogenesis. Springfield, IL: Charles C. Thomas; 1957.
1969	Currey JD. The mechanical consequences of variation in the mineral content of bone. J Biomech. March 1969;2(1):1-11.
1973	Evans FG. Mechanical Properties of Bone. Springfield, IL: Charles C. Thomas; 1973.
1976	Carter DR, Hayes WC, Schurman DJ. Fatigue life of compact bone, II: effects of microstructure and density. J Biomech. 1976;9(4):211-218.
1976	Carter DR, Hayes WC. Fatigue life of compact bone, I: effects of stress amplitude, temperature and density. J Biomech. 1976;9(1):27-34.
1973	Ascenzi A, Bonucci E, Simkin A. An approach to the mechanical properties of single osteonic lamellae. J Biomech. May 1973;6(3):227-235.
1970	Evans FG, Riolo ML. Relations between the fatigue life and histology of adult human cortical bone. J Bone Joint Surg. December 1970;52A(8):1579-1586.
1959	Vose GP, Kubala AL Jr. Bone strength: its relationship to x-ray determined ash content. Hum Biol. September 1959;31:261-270.
1971	Vincentelli R, Evans FG. Relations among mechanical properties, collagen fibers, and calcification in adult human cortical bone. J Biomech. May 1971;4(3):193-201.
1976	Saha S, Hayes WC. Tensile impact properties of human compact bone. J Biomech. 1976;9(4):243-251.
1967	Evans FG, Bang S. Differences and relationships between the physical properties and the microscopic structure of human femoral, tibial and fibular cortical bone. Am J Anat. January 1967;120(1):79-88.
1974	Saha S. Tensile Impact Properties of Bone and Their Relation to Microstructure [PhD thesis]. Stanford University; 1974.
1975	Currey JD. The effects of strain rate, reconstruction and mineral content on some mechanical properties of bovine bone. J Biomech. 1975;8(1):81-86.
1969	Evans FG, Vincentelli R. Relation of collagen fiber orientation to some mechanical properties of human cortical bone. J Biomech. 1969;2(1):63-73.

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Year	Entry
1996	Egerer AK, Saha S, McMillan PJ, Rivera J. Morphology of the cement line in human bone and its relationship to bone strength. In: Proceedings of the 15th Southern Biomedical Engineering Conference. March 29-31, 1996; Dayton, OH.7-10.
2009	Chen P-Y, Stokes AG, McKittrick J. Comparison of the structure and mechanical properties of bovine femur bone and antler of the North American elk (Cervus elaphus canadensis). Acta Biomater. February 2009;5(2):693-706.
2004	Wang X, Puram S. The toughness of cortical bone and its relationship with age. Ann Biomed Eng. January 2004;32(1):123-135.
2020	Kohara Y, Kitazawa S, Kitazawa R, Haraguchi R, Arai K, Amasaki H, Soeta S. Localization of DLL1- and NICD-positive osteoblasts in cortical bone during postnatal growth in rats. Biochem Biophys Res Commun. August 20, 2020;529(2):186-190.
2004	Yeni YN, Dong XN, Fyhrie DP, Les CM. The dependence between the strength and stiffness of cancellous and cortical bone tissue for tension and compression: extension of a unifying principle. Bio-med Mater Eng. 2004;14(3):303-310.
1994	Crofts RD, Boyce TM, Bloebaum RD. Aging changes in osteon mineralization in the human femoral neck. Bone. March–April 1994;15(2):147-152.
1997	Yeni YN, Brown CU, Wang Z, Norman TL. The influence of bone morphology on fracture toughness of the human femur and tibia. Bone. November 1997;21(4):453-459.
2016	Bach-Gansmo FL, Brüel A, Jensen MV, Ebbesen EN, Birkedal H, Thomsen JS. Osteocyte lacunar properties and cortical microstructure in human iliac crest as a function of age and sex. Bone. October 2016;91:11-19.
1982	Martin RB, Burr DB. A hypothetical mechanism for the stimulation of osteonal remodelling by fatigue damage. J Biomech. 1982;15(3):137-139.
1984	Lipson SF, Katz JL. The relationship between elastic properties and microstructure of bovine cortical bone. J Biomech. 1984;17(4):231-240.
1985	Burr DB, Martin RB, Schaffler MB, Radin EL. Bone remodeling in response to in vivo fatigue microdamage. J Biomech. 1985;18(3):189-200.
1985	Vincentelli R, Grigoroi M. The effect of Haversian remodeling on the tensile properties of human cortical bone. J Biomech. 1985;18(3):201-207.
1986	Corondan G, Haworth WL. A fractographic study of human long bone. J Biomech. 1986;19(3):207-218.
1988	Burr DB, Schaffler MB, Frederickson RG. Composition of the cement line and its possible mechanical role as a local interface in human compact bone. J Biomech. 1988;21(11):939-945.
2003	Yeni YN, Fyhrie DP. A rate-dependent microcrack-bridging model that can explain the strain rate dependency of cortical bone apparent yield strength. J Biomech. September 2003;36(9):1343-1353.
1998	Guo XE, Liang LC, Goldstein SA. Micromechanics of osteonal cortical bone fracture. J Biomech Eng. February 1998;120(1):112-117.
2008	Hansen U, Zioupos P, Simpson R, Currey JD, Hynd D. The effect of strain rate on the mechanical properties of human cortical bone. J Biomech Eng. February 2008;130(1):011011.
2000	Phelps JB, Hubbard GB, Wang X, Agrawal CM. Microstructural heterogeneity and the fracture toughness of bone. J Biomed Mater Res. September 15, 2000;51(4):735-741.
1993	McCalden RW, McGeough JA, Barker MB, Court-Brown CM. Age-related changes in the tensile properties of cortical bone: the relative importance of changes in porosity, mineralization, and microstructure. J Bone Joint Surg. 1993;75A(8):1193-1205.
2007	Schneider P, Stauber M, Voide R, Stampanoni M, Donahue LR, Müller R. Ultrastructural properties in cortical bone vary greatly in two inbred strains of mice as assessed by synchrotron light based micro‐ and nano‐CT. J Bone Miner Res. October 2007;22(10):1557-1570.
2013	Li S, Demirci E, Silberschmidt VV. Variability and anisotropy of mechanical behavior of cortical bone in tension and compression. J Mech Behav Biomed Mater. May 2013;21:109-120.
2005	O'Brien FJ, Taylor D, Lee TC. The effect of bone microstructure on the initiation and growth of microcracks. J Orthop Res. March 2005;23(2):475-480.
2004	Pithioux M, Subit D, Chabrand P. Comparison of compact bone failure under two different loading rates: experimental and modelling approaches. Med Eng Phys. 2004;26(8):647-653.
2013	Burket JC. Alterations in Tissue Composition and Nanomechanical Properties With Ageing, Osteoporosis, and Treatment [PhD thesis]. Ithaca, NY: Cornell University; January 2013.
2020	Moore JP. Mechanical Response and Damage Evolution of Microstructural Cortical Bone Under Compression and Tension [Master's thesis]. Drexel University; June 2020.
2007	Schneider P. Ultrastructural Phenotyping of Murine Bone Using Synchrotron Micro- and Nano-Computed Tomography [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2007.
2011	Abdel-Wahab AA-GM. Experimental and Numerical Analysis of Deformation and Fracture of Cortical Bone Tissue [PhD thesis]. Loughborough University; August 2011.
2013	Li S. Cutting of Cortical Bone Tissue: Analysis of Deformation and Fracture Process [PhD thesis]. Loughborough University; June 2013.
2002	Egerer AK. The Relationship Between the Osteonal Cement Line and Bone Strength [PhD thesis]. Loma Linda University; June 2002.
2005	George WT. Multiaxial Fracture Characteristics of Aging Human Bone [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; April 2005.
1993	Boyce TM. Aging Changes Within the Human Femoral Neck Cortex [PhD thesis]. University of Utah; August 1993.
1998	Vajda EG. Age-Related Changes in the Microstructure and Mineralization of the Female Proximal Femur [PhD thesis]. University of Utah; March 1998.
2010	Beckstrom AB. Histologic and Geometric Data Challenge the Assumption of Habitual Superior-Inferior (tension-Compression) Bending Across the Chimpanzee Proximal Femur [Master's thesis]. University of Utah; August 2010.
2010	Wynnyckyj C. The Consequences of Collagen Degradation on Bone Mechanical Properties [PhD thesis]. University of Toronto; 2010.
1985	Schaffler MB. Stiffness and Fatigue of Compact Bone At Physiological Strains and Strain Rates [PhD thesis]. Morgantown, WV: West Virginia University; 1985.
1998	Yeni YN. Fracture Mechanics of Human Cortical Bone: The Relationship of Geometry, Microstructure and Composition With the Fracture of the Tibia, Femoral Shaft and the Femoral Neck [PhD thesis]. Morgantown, WV: West Virginia University; 1998.