Response of joints to impact loading, III:​ relationship between trabecular microfractures and cartilage degeneration

Radin, Eric L.; Parker, Howard G.; Pugh, James W.; Steinberg, Robert S.; Paul, Igor L.; Rose, Robert M.

Abstract

The knee joints of adult rabbits were subjected to daily one hour intervals of impulsive loading equivalent to their body weight at 60 cpm. They developed changes in their knee joints consistent with those of degenerative joint disease. The cartilage destruction was preceded by stiffening of the underlying subchondral bone. Numerous healing trabecular microfractures were associated with this increased stiffening. Similar microfractures have been observed in human specimens. The implications of these findings to bone remodelling and osteoarthritis are discussed.

Links

DOI: 10.1016/0021-9290(73)90037-7

PubMed: 4693868

ISI: A1973O698300006

Affiliations

¹Orthopedic Research Laboratories, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, U.S.A.

²Department of Mechanical Engineering, M. I. T., 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, U.S.A.

³Department of Metallurgy and Materials Sciences, M. I. T., 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, U.S.A.

History

Received: 1972-03-24

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Cited By (27)

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