Response of joints to impact loading, III:​ relationship between trabecular microfractures and cartilage degeneration

Radin, Eric L.; Parker, Howard G.; Pugh, James W.; Steinberg, Robert S.; Paul, Igor L.; Rose, Robert M.

Abstract

The knee joints of adult rabbits were subjected to daily one hour intervals of impulsive loading equivalent to their body weight at 60 cpm. They developed changes in their knee joints consistent with those of degenerative joint disease. The cartilage destruction was preceded by stiffening of the underlying subchondral bone. Numerous healing trabecular microfractures were associated with this increased stiffening. Similar microfractures have been observed in human specimens. The implications of these findings to bone remodelling and osteoarthritis are discussed.

Links

DOI: 10.1016/0021-9290(73)90037-7

PubMed: 4693868

ISI: A1973O698300006

Affiliations

¹Orthopedic Research Laboratories, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, U.S.A.

²Department of Mechanical Engineering, M. I. T., 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, U.S.A.

³Department of Metallurgy and Materials Sciences, M. I. T., 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, U.S.A.

History

Received: 1972-03-24

Cited Works (4)

Year	Entry
1970	McElhaney J, Alem N, Roberts V. A porous block model for cancellous bones. Winter Annual Meeting of the American Society of Mechanical Engineers; November 29–December 3, 1970; New York, NY.1-9. ASME Publication 70-WA/BHF-2.
1970	Piekarski K. Fracture of bone. J Appl Phys. January 1970;41(1):215-223.
1960	Frost HM. Presence of microscopic cracks in vivo in bone. Henry Ford Hosp Med Bull. 1960;8:25-35.
1966	Swanson SAV, Freeman MAR. Is bone hydraulically strengthened? Med Biol Eng. September 1966;4(5):433-438.

Cited By (31)

Year	Entry
2005	O’Connor J. Mechanical factors in osteoarthrosis: contribution of repetitive impulsive loads to the development of the cartilage failure in human joints. In: Gilchrist MD, ed. IUTAM Symposium on Impact Biomechanics: From Fundamental Insights to Applications. Dordrecht, The Netherlands: Springer; 2005:339-346. Solid Mechanics and Its Applications; vol 124.
1997	Atkinson PJ, Garcia JJ, Altiero NJ, Haut RC. The influence of impact interface on human knee injury: implications for instrument panel design and the lower extremity injury criterion. In: Proceedings of the 41st Stapp Car Crash Conference. November 13-14, 1997; Lake Buena Vista, FL. Warrendale, PA: Society of Automotive Engineers:167-180. SAE 973327.
1995	Schaffler MB, Choi K, Milgrom C. Aging and matrix microdamage accumulation in human compact bone. Bone. December 1995;17(6):521-525.
1996	Wenzel TE, Schaffler MB, Fyhrie DP. In vivo trabecular microcracks in human vertebral bone. Bone. August 1996;19(2):89-95.
1993	Fazzalari NL. Trabecular microfracture. Calcif Tiss Int. February 1993;53(suppl 1):S143-S147.
1986	Radin EL, Rose RM. Role of subchondral bone in the initiation and progression of cartilage damage. Clin Orthop Relat Res. December 1986;213:34-40.
1990	Burr DB, Stafford T. Validity of the bulk-staining technique to separate artifactual from in vivo bone microdamage. Clin Orthop Relat Res. November 1990;260:305-308.
2001	Bandak FA, Tannous RE, Toridis T. On the development of an osseo-ligamentous finite element model of the human ankle joint. Int J Solids Struct. March 2001;38(10-13):1681-1697.
1973	Pugh JW, Rose RM, Radin EL. Elastic and viscoelastic properties of trabecular bone: dependence on structure. J Biomech. 1973;6(5):475-485.
1977	Carter DR, Hayes WC. Compact bone fatigue damage, I: residual strength and stiffness. J Biomech. 1977;10(5-6):325-337.
1979	Lakes RS, Katz JL. Viscoelastic properties of wet cortical bone, III: a non-linear constitutive equation. J Biomech. 1979;12(9):689-698.
1980	Viano DC, Stalnaker RL. Mechanisms of femoral fracture. J Biomech. 1980;13(8):701-715.
1987	Carter DR, Fyhrie DP, Whalen RT. Trabecular bone density and loading history: regulation of connective tissue biology by mechanical energy. J Biomech. 1987;20(8):785-794.
1986	Panjabi MM, Andersson GB, Jorneus L, Hult E, Mattsson L. In vivo measurements of spinal column vibrations. J Bone Joint Surg. June 1986;68A(5):695-702.
1987	Hoshino A, Wallace WA. Impact-absorbing properties of the human knee. J Bone Joint Surg. November 1987;69B(5):807-811.
1998	Swartz SM, Parker A, Huo C. Theoretical and empirical scaling patterns and topological homology in bone trabeculae. J Exp Biol. February 1998;201(4):573-590.
2020	Martig S, Hitchens PL, Lee PVS, Whitton RC. The relationship between microstructure, stiffness and compressive fatigue life of equine subchondral bone. J Mech Behav Biomed Mater. January 2020;101:103439.
1989	Haut RC. Contact pressures in the patellofemoral joint during impact loading on the human flexed knee. J Orthop Res. March 1989;7(2):272-280.
1995	Atkinson PJ, Haut RC. Subfracture insult to the human cadaver patellofemoral joint produces occult injury. J Orthop Res. November 1995;13(6):936-944.
1979	Lakes R, Saha S. Cement line motion in bone. Science. May 4, 1979;204(4392):501-503.
1981	Hansson T, Roos B. Microcalluses of the trabeculae in lumbar vertebrae and their relation to the bone mineral content. Spine. July–August 1981;6(4):375-380.
1983	Sandover J. Dynamic loading as a possible source of low-back disorders. Spine. September 1983;8(6):652-658.
2000	Akkus O. The Relation of Microdamage to Fracture and Material Property Degradation in Human Cortical Bone Tissue [PhD thesis]. Cleveland, OH: Case Western Reserve University; August 2000.
2006	Joo W. Cross-Modal Effects of Damage on Mechanical Behavior of Human Cortical Bone [PhD thesis]. Cleveland, OH: Case Western Reserve University; January 2006.
1993	Guo X-DE. Fatigue of Trabecular Bone [PhD thesis]. Cambridge, MA: Harvard University; 1993.
2018	Yan C. Effect of Fatigue Loading on Impact Response of Rat Ulna [Master's thesis]. Urbana, IL: University of Illinois at Urbana-Champaign; 2018.
2010	Johnston JD. Development of a Non-Invasive Imaging Technique for Characterizing Subchondral Bone Density and Stiffness [PhD thesis]. Vancouver, BC: University of British Columbia; December 2010.
2001	Boyd SK. Microstructural Bone Adaptation in an Experimental Model of Osteoarthritis [PhD thesis]. Calgary, AB: University of Calgary; January 2001.
1998	Ciarelli TE. Architectural and Material Contributions to Fracture of the Spine and Proximal Femur [PhD thesis]. Ann Arbor, MI: University of Michigan; 1998.
2018	Hosseini Kalajahi SM. Addressing Partial Volume Artifacts With Quantitative Computed Tomography-Based Finite Element Modeling of the Human Proximal Tibia [Master's thesis]. Saskatoon, SK: University of Saskatchewan; April 2018.
1985	Schaffler MB. Stiffness and Fatigue of Compact Bone At Physiological Strains and Strain Rates [PhD thesis]. Morgantown, WV: West Virginia University; 1985.