Occupant safety is one of the most important issues for vehicle manufacturing. Active safety plays an important role to protect the occupant during the crash events. In this paper, vehicle dynamics control systems (VDCS) are used to enhance the occupant safety in offset frontal vehicle collision. VDCS are activated to optimize the vehicle in impending collision. A new mathematical modelling of the vehicle alongside VDCS is developed to study the effect of vehicle dynamics control systems on vehicle collision mitigation. A multi -body occupant mathematical model is developed to capture the occupant kinematics during frontal offset collision. Different cases of vehicle dynamics control systems have been used to show their effect on the occupant dynamic response. The occupant deceleration and the occupant's chest and head rotational acceleration are used as injury criteria. It is shown from the numerical simulations that the occupant behaviour can be captured and analysed quickly and accurately. Furthermore, it is shown that the VDCS can affect the crash characteristics positively and the occupant safety is improved.