Microstructures and properties of cancellous bone of avascular necrosis of femoral heads

Yao, Xuefeng; Wang, Peng; Dai, Ruchun; Yeh, Hsien Yang

Affiliations

¹Department of Engineering Mechanics, AML, Tsinghua University, 100084 Beijing, China

²Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, 410011 Changsha, China

³Department of Mechanical and Aerospace Engineering, California State University, Long Beach, CA 90840-8305, USA

Abstract and keywords

The aim of this study is to investigate microscopic structure and characterize cancellous bone of avascular necrosis of the femoral head (ANFH). The rabbit model of the ANFH is established. The histopathologic features are studied successfully. The differences between the steroidinjection group (S.G.) and the controlled group (C.G.) are examined, including the weight of rabbits, the hematological examination and the three-dimensional structures. It is found that the plasma levels of cholesterol (CHO), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) in S.G. are lower than those in C.G. when the triglyceride (TG) increased in the S.G.; but the bone mineral content (BMC) and the structural model index (SMI) of the organ and tissue decreased significantly in S.G. Three-dimensional structures of the femoral head are obtained usingmicro-computed tomography (CT) scanning and the mechanical model is established to analyze the influences of these structural changes on themechanical properties of the cancellous bone.

Keywords: Avascular necrosis of the femoral head; Cancellous bone; Microstructure; Mechanical properties

Links

DOI: 10.1007/s10409-009-0309-8

WoS: 000274707800004

Cited Works (6)

Year	Entry
1997	Hildebrand T, Rüegsegger P. Quantification of bone microarchitecture with the structure model index. Comput Methods Prog Biomed. 1997;1(1):15-23.
1993	Odgaard A, Gundersen HJG. Quantification of connectivity in cancellous bone, with special emphasis on 3-D reconstructions. Bone. March–April 1993;14(2):173-182.
2005	Gibson LJ. Biomechanics of cellular solids. J Biomech. 2005;38(3):377-399.
1993	Fung YC. Biomechanics: Mechanical Properties of Living Tissues. 2nd ed. New York, NY: Springer-Verlag; 1993.
1997	Hildebrand T, Rüegsegger P. A new method for the model-independent assessment of thickness in three-dimensional images. J Microsc (Oxford). 1997;185(1):67-75.
1997	Laib A, Hildebrand T, Häuselmann HJ, Rüegsegger P. Ridge number density: a new parameter for in vivo bone structure analysis. Bone. December 1997;21(6):541-546.