In vivo thresholds for mechanical injury to the blood-brain barrier

Shreiber, David I.<sup>1</sup>; Bain, Allison C.<sup>1</sup>; Meaney, David F.<sup>1</sup>

Year	Entry
2005	Doorly MC, Horgan TJ, Gilchrist MD. Reconstruction of head injury cases arising from falls using the UCD brain trauma model. In: Gilchrist MD, ed. IUTAM Symposium on Impact Biomechanics: From Fundamental Insights to Applications. Dordrecht, The Netherlands: Springer; 2005:431-440. Solid Mechanics and Its Applications; vol 124.
2015	Melvin JW, Yoganandan N. Biomechanics of brain injury: a historical perspective. In: Yoganandan N, Nahum AM, Melvin JW, eds. Accidental Injury: Biomechanics and Prevention. 3rd ed. New York: Springer; 2015:221-245.
2011	Lamy M, Baumgartner D, Willinger R, Yoganandan N, Stemper BD. Study of mild traumatic brain injuries using experiments and finite element modeling. In: 55th Annual Proceedings, Association for the Advancement of Automotive Medicine (AAAM). October 3-5, 2011; Paris, France.125-135.
2007	Kleiven S. A parametric study of energy absorbing foams for head injury prevention. In: Proceedings of the 20th International Technical Conference on the Enhanced Safety of Vehicles (ESV). June 18-21, 2007; Lyon, France.
2005	Kleiven S. Influence of direction and duration of impacts to the human head evaluated using the finite element method. In: Proceedings of the 2005 International IRCOBI Conference on the Biomechanics of Impact. September 21-23, 2005; Prague, Czech Republic.41-57.
2007	Mordaka J, Kleiven S, van Schijndel-de Nooij M, de Lange R, Guerra Casanova LJ, Carter EL, von Holst H. The importance of rotational kinematics in pedestrian head to windshield impacts. In: Proceedings of the 2007 International IRCOBI Conference on the Biomechanics of Impact. September 19-21, 2007; Maastricht, The Netherlands.83-94.
2011	Lamy M, Baumgartner D, Yoganandan N, Willinger R. Mild traumatic brain injury in the rat: three‐dimensional finite element model using experimental data. In: Proceedings of the 2011 International IRCOBI Conference on the Biomechanics of Injury. September 14-16, 2011; Krakow, Poland.23-35.
2012	Fahlstedt M, Baeck K, Halldin P, Vander Sloten J, Goffin J, Depreitere B, Kleiven S. Influence of impact velocity and angle in a detailed reconstruction of a bicycle accident. In: Proceedings of the 2012 International IRCOBI Conference on the Biomechanics of Injury. September 12-14, 2012; Dublin, Ireland.787-799.
2013	Lamy M, Baumgartner D, Davidsson J, Willinger R. Traumatic brain injury investigation using FE modeling of the rat and experimental high amplitude rotations in the sagittal plane. In: Proceedings of the 2013 International IRCOBI Conference on the Biomechanics of Injury. September 11-13, 2013; Gothenburg, Sweden.456-469.
2015	Clark JM, Post A, Hoshizaki TB, Gilchrist MD. Determining the relationship between linear and rotational acceleration and MPS for different magnitudes of classified brain injury risk in ice hockey. In: Proceedings of the 2015 International IRCOBI Conference on the Biomechanics of Injury. September 9-11, 2015; Lyon, France.168-179.
2016	Alvarez VS, Kleiven S. Importance of windscreen modelling approach for head injury prediction. In: Proceedings of the 2016 International IRCOBI Conference on the Biomechanics of Injury. September 14-16, 2016; Malaga, Spain.813-830.
2020	Pipkorn B, Alvarez V, Fahlstedt M, Lundin L. Head injury risks and countermeasures for a bicyclist impacted by a passenger vehicle. In: Proceedings of the 2020 International IRCOBI Conference on the Biomechanics of Injury. 2020; Munich, Germany.289-306.
2022	Fahlstedt M, Bergström J, Lanner D, Halldin P. How efficient are the rotational impact tests in ECE R22.06 motorcycle helmet test standard to decrease the rotational-induced brain injuries? In: Proceedings of the 2022 International IRCOBI Conference on the Biomechanics of Injury. September 14-16, 2022; Porto, Portugal.912-923.
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1999	Bain AC, Meaney DF. Thresholds for mechanical injury to the in vivo white matter. In: Proceedings of the 43rd Stapp Car Crash Conference. October 25-27, 1999; San Diego, CA. Warrendale, PA: Society of Automotive Engineers:295-302. SAE 99SC19.
1999	Miller RT, Smith DH, Chen X, Xu B-N, Leoni M, Nonaka M, Meaney DF. Comparing experimental data to traumatic brain injury finite element models. In: Proceedings of the 43rd Stapp Car Crash Conference. October 25-27, 1999; San Diego, CA. Warrendale, PA: Society of Automotive Engineers:303-311. SAE 99SC20.
2000	Prange M, Meaney DF, Margulies SS. Defining brain mechanical properties: effects of region, direction, and species. Stapp Car Crash J. 2000;44:205-213. SAE 2000-01-SC15.
2002	Brands DWA, Bovendeerd PHM, Wismans JSHM. On the potential importance of non-linear viscoelastic material modelling for numerical prediction of brain tissue response: test and application. Stapp Car Crash J. 2002;46:103-121. SAE 2002-22-0006.
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2006	Jin X, Lee JB, Leung LY, Zhang L, Yang KH, King AI. Biomechanical response of the bovine pia-arachnoid complex to tensile loading at varying strain rates. Stapp Car Crash J. 2006;50:637-649. SAE 2006-22-0025.
2006	Mao H, Zhang L, Yang KH, King AI. Application of a finite element model of the brain to study traumatic brain injury mechanisms in the rat. Stapp Car Crash J. 2006;50:583-600. SAE 2006-22-0022.
2007	Kleiven S. Predictors for traumatic brain injuries evaluated through accident reconstructions. Stapp Car Crash J. 2007;51:81-114. SAE 2007-22-0003.
2008	Takhounts EG, Ridella SA, Hasija V, Tannous RE, Campbell JQ, Malone D, Danelson K, Stitzel J, Rowson S, Duma S. Investigation of traumatic brain injuries using the next generation of Simulated Injury Monitor (SIMon) finite element head model. Stapp Car Crash J. 2008;52:1-31. SAE 2008-22-0001.
2009	Fijalkowski RJ, Yoganandan N, Zhang J, Pintar FA. A finite element model of region-specific response for mild diffuse brain injury. Stapp Car Crash J. 2009;53:193-213. SAE 2009-22-0007.
2014	Alvarez VS, Halldin P, Kleiven S. The influence of neck muscle tonus and posture on brain tissue strain in pedestrian head impacts. Stapp Car Crash J. November 2014;58:63-101.
2014	Giordano C, Kleiven S. Evaluation of axonal strain as a predictor for mild traumatic brain injuries using finite element modeling. Stapp Car Crash J. November 2014;58:29-61.
2010	Chafi MS, Karami G, Ziejewski M. Biomechanical assessment of brain dynamic responses due to blast pressure waves. Ann Biomed Eng. February 2010;38(2):490-504.
2005	Nicolle S, Lounis M, Willinger R, Palierne J-F. Shear linear behavior of brain tissue over a large frequency range. Biorheology. 2005;42(3):209-223.
2006	Doorly MC, Gilchrist MD. The use of accident reconstruction for the analysis of traumatic brain injury due to head impacts arising from falls. Comput Methods Biomech Biomed Eng. December 2006;9(6):371-377.
2011	Forero Rueda MA, Cuia L, Gilchrist MD. Finite element modelling of equestrian helmet impacts exposes the need to address rotational kinematics in future helmet designs. Comput Methods Biomech Biomed Eng. December 2011;14(12):1021-1031.
2013	Post A, Oeur A, Hoshizaki B, Gilchrist MD. Examination of the relationship between peak linear and angular accelerations to brain deformation metrics in hockey helmet impacts. Comput Methods Biomech Biomed Eng. 2013;16(5):511-519.
2004	Horgan TJ, Gilchrist MD. Influence of FE model variability in predicting brain motion and intracranial pressure changes in head impact simulations. Int J Crashworthiness. 2004;9(4):401-418.
2013	Patton DA, McIntosh AS, Kleiven S. The biomechanical determinants of concussion: finite element simulations to investigate brain tissue deformations during sporting impacts to the unprotected head. J Appl Biomech. December 2013;29(6):721-730.
2006	Cater HL, Sundstrom LE, Morrison B III. Temporal development of hippocampal cell death is dependent on tissue strain but not strain rate. J Biomech. 2006;39(16):2810-2818.
2012	Post A, Hoshizaki B, Gilchrist MD. Finite element analysis of the effect of loading curve shape on brain injury predictors. J Biomech. February 23, 2012;45(4):679-683.
2021	Zimmerman KA, Kim J, Karton C, Lochhead L, Sharp DJ, Hoshizaki T, Ghajari M. Player position in American football influences the magnitude of mechanical strains produced in the location of chronic traumatic encephalopathy pathology: a computational modelling study. J Biomech. March 30, 2021;118:110256.
2000	Margulies SS, Thibault KL. Infant skull and suture properties: measurements and implications for mechanisms of pediatric brain injury. J Biomech Eng. August 2000;122(4):364-371.
2002	Prange MT, Margulies SS. Regional, directional, and age-dependent properties of the brain undergoing large deformation. J Biomech Eng. 2002;124(2):244-252.
2006	Geddes-Klein DM, Schiffman KB, Meaney DF. Mechanisms and consequences of neuronal stretch injury in vitro differ with the model of trauma. J Neurotrauma. February 2006;23(2):193-204.
2000	Anderson RWG. A Study on the Biomechanics of Axonal Injury [PhD thesis]. Adelaide, Australia: University of Adelaide; 2000.
2018	Bharadwaj VN. Comprehensive Assessment of Nanoparticle Delivery After Experimental Traumatic Brain Injury [PhD thesis]. Arizona State University; May 2018.
2013	Antona-Makoshi J. Reanalysis of Primate Head Impact Experiments to Clarify Mild Traumatic Brain Injury Kinematics and Thresholds [PhD thesis]. Gothenburg, Sweden: Chalmers University of Technology; 2013.
2011	Wester B. Development and Characterization of Mechanically Actuated Microtweezers for Use in a Single-Cell Neural Injury Model [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; May 2011.
2019	Meng S. Towards Improved Motorcycle Helmet Test Methods for Head Impact Protection: Using Experimental and Numerical Methods [PhD thesis]. Huddinge, Sweden: KTH Royal Institute of Technology; 2019.
2009	Verschueren P. Biomechanical Analysis of Head Injuries Related to Bicycle Accidents and a New Bicycle Helmet Concept [PhD thesis]. Leuven, Belgium: Katholieke Universiteit Leuven; July 2009.
2008	Fijalkowski RJ. Rotational Acceleration Pulse Characteristics Affect Mild Diffuse Brain Injury Severity [PhD thesis]. Marquette University; May 2008.
2007	Maikos J. In Vivo Tissue-Level Thresholds for Spinal Cord Injury [PhD thesis]. Rutgers University; October 2007.
2019	Jannesar S. The Mechanics of Contusion Spinal Cord Injury: Towards Patient-Specific Assessments of Mechanical Loading and Injury [PhD thesis]. Simon Fraser University; Summer 2019.
2002	Brands DWA. Predicting Brain Mechanics During Closed Head Impact: Numerical and Constitutive Aspects [PhD thesis]. Eindhoven, The Netherlands: Technische Universiteit Eindhoven; March 14, 2002.
2023	Li Y. Toward a Biofidelic and Repeatable Physical Head-Brain Model for Application in Blunt Impact [PhD thesis]. Edmonton, AB: University of Alberta; 2023.
2012	Russell CM. A Nonlinear Finite Element Model of the Rat Cervical Spine: Validation and Correlation With Histological Measures of Spinal Cord Injury [Master's thesis]. Vancouver, BC: University of British Columbia; August 2012.
2001	Monson KL. Mechanical and Failure Properties of Human Cerebral Blood Vessels [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2001.
2014	Patton DA. The Biomechanical Determinants of Sports-Related Concussion: Finite Element Simulations of Unhelmeted Head Impacts to Evaluate Kinematic and Tissue-Level Predictors of Injury and Investigate the Design Implications for Soft-Shell Headgear [PhD thesis]. University of New South Wales; March 2014.
2012	Oeur A. An Analysis of Head Impact Angle on the Dynamic Response of a Hybrid III Headform and Brain Tissue Deformation [Master's thesis]. Ottawa, ON: University of Ottawa; December 2012.
2016	Kendall M. Comparison and Characterization of Different Concussive Brain Injury Events [PhD thesis]. University of Ottawa; 2016.
2010	Miller W. Mechanisms of Astrocytic Calcium Wave Propagation and in Vitro Hippocampal Cell Death Are Determined by the Magnitude of Mechanical Injury [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2010.
2014	Chen Y. Astrocyte Signaling in Traumatic Brain Injury [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2014.
2010	Mathur V. Computational Modeling of Controlled Cortical Impact in a Mouse [Master's thesis]. University of Utah; December 2010.
2015	Kim H. Characterization of Brain Surface Strains During Controlled Cortical Impact [Master's thesis]. University of Utah; May 2015.
2009	Jin X. Biomechanical Response and Constitutive Modeling of Bovine Pia-Arachnoid Complex [PhD thesis]. Detroit, MI: Wayne State University; December 2009.
2009	Mao H. Computational Analysis of in Vivo Brain Trauma [PhD thesis]. Detroit, MI: Wayne State University; August 2009.
2020	Zhou R. Development of Rat Head Finite Element Model and Tissue Level Biomechanical Threshold for Traumatic Axonal Injury [PhD thesis]. Detroit, MI: Wayne State University; May 2020.
2019	Bian K. Predicting and Preventing Traumatic Brain Injury: A Novel Computational Approach [Master's thesis]. London, ON: Western University; August 2019.