The role of three-dimensional trabecular microstructure in the pathogenesis of vertebral compression fractures

Kleerekoper, M.; Villanueva, A. R.; Stanciu, J.; Rao, D. Sudhaker; Parfitt, A. M.

Year	Entry
1992	Bradbeer JN, Arlott ME, Meunier PJ, Reeve J. Treatment of osteoporosis with parathyroid peptide (hPTH 1-34) and oestrogen: increase in volumetric density of iliac cancellous bone may depend on reduced trabecular spacing as well as increased thickness of packets of newly formed bone. Clin Endocrinol. September 1992;37(3):282-289.
1999	Laib A, Rüegsegger P. Comparison of structure extraction methods for in vivo trabecular bone measurements. Comput Vis Image Understand. March–April 1999;23(2):69-74.
2002	Wehrli F, Saha P, Gomberg B, Song H, Snyder P, Benito M, Wright A, Weening R. Role of magnetic resonance for assessing structure and function of trabecular bone. Top Magn Reson Imaging. October 2002;13(5):335-355.
2008	Zhang Y, He Z, Fan S, He K, Li C. Automatic thresholding of micro-CT trabecular bone images. Proceedings of the International Conference on BioMedical Engineering and Informatics (BMEI 2008); May 27-30, 2008; Sanya, Hainan, China.23-27.
1994	Schueler F, Zimmer G, Min J, Mattern R. Assessment of mechanical properties of the human skull-cap through basic biomechanical tests and quantitative computed tomography (QCT). In: Proceedings of the 1994 International IRCOBI Conference on the Biomechanics of Impact. September 21-23, 1994; Lyon, France.23-37.
2000	Ding M. Age variations in the properties of human tibial trabecular bone and cartilage. Acta Orthop Scand. 2000;71(suppl 292):1-45.
2002	Banse X. When density fails to predict bone strength. Acta Orthop Scand. 2002;73(2)(suppl 303):2-57.
1987	Parfitt AM. Trabecular bone architecture in the pathogenesis and prevention of fracture. Am J Med. January 26, 1987;82(suppl 1B):68-72.
2001	Borah B, Gross GJ, Dufresne TE, Smith TS, Cockman MD, Chmielewski PA, Lundy MW, Hartke JR, Sod EW. Three‐dimensional microimaging (MRμI and μCT), finite element modeling, and rapid prototyping provide unique insights into bone architecture in osteoporosis. Anat Rec. April 15, 2001;265(2):101-110.
2003	Frost HM. Bone's mechanostat: a 2003 update. Anat Rec. 2003;275A(2):1081-1101.
1996	Amling M, Pösl M, Ritzel H, Hahn M, Vogel M, Wening VJ, Delling G. Architecture and distribution of cancellous bone yield vertebral fracture clues: a histomorphometric analysis of the complete spinal column from 40 autopsy specimens. Arch Orthop Trauma Surg. July 1996;115(5):262-269.
1987	Mosekilde L, Mosekilde L, Danielsen CC. Biomechanical competence of vertebral trabecular bone in relation to ash density and age in normal individuals. Bone. 1987;8(2):79-85.
1987	Weinstein RS, Hutson MS. Decreased trabecular width and increased trabecular spacing contribute to bone loss with aging. Bone. 1987;8(3):137-142.
1987	Garrahan NJ, Mellish RWE, Vedi S, Compston JE. Measurement of mean trabecular plate thickness by a new computerized method. Bone. 1987;8(4):227-230.
1987	Compston JE, Mellish RWE, Garrahan NJ. Age-related changes in iliac crest trabecular microanatomic bone structure in man. Bone. 1987;8(5):289-292.
1988	Mosekilde L, Mosekilde L. Iliac crest trabecular bone volume as predictor for vertebral compressive strength, ash density and trabecular bone volume in normal individuals. Bone. 1988;9(4):195-199.
1988	Mosekilde L. Age-related changes in vertebral trabecular bone architecture—assessed by a new method. Bone. 1988;9(4):247-250.
1988	Parisien MV, McMahon D, Pushparaj N, Dempster DW. Trabecular architecture in iliac crest bone biopsies: infra-individual variability in structural parameters and changes with age. Bone. 1988;9(5):289-295.
1989	Vesterby A, Gundersen H, Melsen F. Star volume of marrow space and trabeculae of the first lumbar vertebra: sampling efficiency and biological variation. Bone. 1989;10(1):7-13.
1989	Mosekilde L. Sex differences in age-related loss of vertebral trabecular bone mass and structure—biomechanical consequences. Bone. 1989;10(6):425-432.
1989	Mosekilde L, Bentzen SM, Ørtoft G, Jørgensen J. The predictive value of quantitative computed tomography for vertebral body compressive strength and ash density. Bone. 1989;10(6):465-470.
1990	Mosekilde L, Mosekilde L. Sex differences in age-related changes in vertebral body size, density and biomechanical competence in normal individuals. Bone. 1990;11(2):67-73.
1990	Vesterby A. Star volume of marrow space and trabeculae in iliac crest: sampling procedure and correlation to star volume of first lumbar vertebra. Bone. 1990;11(3):149-155.
1990	Jensen KS, Mosekilde L, Mosekilde L. A model of vertebral trabecular bone architecture and its mechanical properties. Bone. 1990;11(6):417-423.
1991	Vesterby A, Mosekilde L, Gundersen HJG, Melsen F, Mosekilde L, Holme K, Sørensen S. Biologically meaningful determinants of the in vitro strength of lumbar vertebrae. Bone. 1991;12(3):219-224.
1992	Hahn M, Vogel M, Pompesius-Kempa M, Delling G. Trabecular bone pattern factor: a new parameter for simple quantification of bone microarchitecture. Bone. 1992;13(4):327-330.
1992	Parfitt AM. Implications of architecture for the pathogenesis and prevention of vertebral fracture. Bone. 1992;13(suppl 2):S41-S47.
1993	Odgaard A, Gundersen HJG. Quantification of connectivity in cancellous bone, with special emphasis on 3-D reconstructions. Bone. March–April 1993;14(2):173-182.
1995	Grote HJ, Amling M, Vogel M, Hahn M, Pösl M, Delling G. Intervertebral variation in trabecular microarchitecture throughout the normal spine in relation to age. Bone. March 1995;16(3):301-308.
1996	Müller R, Hahn M, Vogel M, Delling G, Rüegsegger P. Morphometric analysis of noninvasively assessed bone biopsies: comparison of high-resolution computed tomography and histologic sections. Bone. March 1996;18(3):215-220.
1997	Odgaard A. Three-dimensional methods for quantification of cancellous bone architecture. Bone. 1997;20(4):315-328.
1997	Laib A, Hildebrand T, Häuselmann HJ, Rüegsegger P. Ridge number density: a new parameter for in vivo bone structure analysis. Bone. December 1997;21(6):541-546.
1998	Mullender M, van Rietbergen B, Rüegsegger P, Huiskes R. Effect of mechanical set point of bone cells on mechanical control of trabecular bone architecture. Bone. February 1998;22(2):125-131.
1998	Thomsen JS, Ebbesen EN, Mosekilde L. Relationships between static histomorphometry and bone strength measurements in human iliac crest bone biopsies author links open overlay panel. Bone. February 1998;22(2):153-163.
1998	Majumdar S, Kothari M, Augat P, Newitt DC, Link TM, Lin JC, Lang T, Lu Y, Genant HK. High-resolution magnetic resonance imaging: three-dimensional trabecular bone architecture and biomechanical properties. Bone. May 1998;22(5):445-454.
1998	Ito M, Nakamura T, Matsumoto T, Tsurusaki K, Hayashi K. Analysis of trabecular microarchitecture of human iliac bone using microcomputed tomography in patients with hip arthrosis with or without vertebral fracture. Bone. August 1998;23(2):163-169.
1999	Laib A, Rüegsegger P. Calibration of trabecular bone structure measurements of in vivo three-dimensional peripheral quantitative computed tomography with 28-μm-resolution microcomputed tomography. Bone. January 1999;24(1):35-39.
1999	Kabel J, Odgaard A, van Rietbergen B, Huiskes R. Connectivity and the elastic properties of cancellous bone. Bone. 1999;24(2):115-120.
1999	Yeh OC, Keaveny TM. Biomechanical effects of intraspecimen variations in trabecular architecture: a three-dimensional finite element study. Bone. August 1999;25(2):223-228.
1999	Uchiyama T, Tanizawa T, Muramatsu H, Endo N, Takahashi HE, Hara T. Three-dimensional microstructural analysis of human trabecular bone in relation to its mechanical properties. Bone. 1999;25(4):487-491.
2000	Day JS, Ding M, Odgaard A, Sumner DR, Hvid I, Weinans H. Parallel plate model for trabecular bone exhibits volume fraction-dependent bias. Bone. November 2000;27(5):715-720.
2002	Guo XE, Kim CH. Mechanical consequence of trabecular bone loss and its treatment: a three-dimensional model simulation. Bone. February 2002;30(2):404-411.
2002	Thomsen JS, Ebbesen EN, Mosekilde L. Predicting human vertebral bone strength by vertebral static histomorphometry. Bone. March 2002;30(3):502-508.
2002	Ito M, Nishida A, Nakamura T, Uetani M, Hayashi K. Differences of three-dimensional trabecular microstructure in osteopenic rat models caused by ovariectomy and neurectomy. Bone. April 2002;30(4):594-598.
2002	Homminga J, McCreadie BR, Ciarelli TE, Weinans H, Goldstein SA, Huiskes R. Cancellous bone mechanical properties from normals and patients with hip fractures differ on the structure level, not on the bone hard tissue level. Bone. May 2002;30(5):759-764.
2007	Hulme PA, Boyd SK, Ferguson SJ. Regional variation in vertebral bone morphology and its contribution to vertebral fracture strength. Bone. December 2007;41(6):946-957.
2004	Homminga J, Van-Rietbergen B, Lochmüller EM, Weinans H, Eckstein F, Huiskes R. The osteoporotic vertebral structure is well adapted to the loads of daily life, but not to infrequent "error" loads. Bone. March 2004;34(3):510-516.
2004	Borah B, Dufresne TE, Chmielewski PA, Johnson TD, Chines A, Manhart MD. Risedronate preserves bone architecture in postmenopausal women with osteoporosis as measured by three-dimensional microcomputed tomography. Bone. April 2004;34(4):736-746.
2007	Sran MM, Boyd SK, Cooper DML, Khan KM, Zernicke RF, Oxland TR. Regional trabecular morphology assessed by micro-CT is correlated with failure of aged thoracic vertebrae under a posteroanterior load and may determine the site of fracture. Bone. March 2007;40(3):751-757.
2007	MacNeil JA, Boyd SK. Load distribution and the predictive power of morphological indices in the distal radius and tibia by high resolution peripheral quantitative computed tomography. Bone. July 2007;41(1):129-137.
2009	Mueller TL, van Lenthe GH, Stauber M, Gratzke C, Eckstein F, Müller R. Regional, age and gender differences in architectural measures of bone quality and their correlation to bone mechanical competence in the human radius of an elderly population. Bone. November 2009;45(5):882-891.
2010	Viguet-Carrin S, Follet H, Gineyts E, Roux JP, Munoz F, Chapurlat R, Delmas PD, Bouxsein ML. Association between collagen cross-links and trabecular microarchitecture properties of human vertebral bone. Bone. February 2010;46(2):342-347.
2011	Mueller TL, Christen D, Sandercott S, Boyd SK, van Rietbergen B, Eckstein F, Lochmüller E-M, Müller R, van Lenthe GH. Computational finite element bone mechanics accurately predicts mechanical competence in the human radius of an elderly population. Bone. June 1, 2011;48(6):1232-1238.
2013	Thomsen JS, Niklassen AS, Ebbesen EN, Brüel A. Age-related changes of vertical and horizontal lumbar vertebral trabecular 3D bone microstructure is different in women and men. Bone. November 2013;57(1):47-55.
2020	Jin Y, Zhang T, Cheung JPY, Wong TM, Feng X, Sun T, Zu H, Sze KY, Lu WW. A novel mechanical parameter to quantify the microarchitecture effect on apparent modulus of trabecular bone: a computational analysis of ineffective bone mass. Bone. June 2020;135:115314.
2020	Bailey S, Hackney D, Vashishth D, Alkalay RN. The effects of metastatic lesion on the structural determinants of bone: current clinical and experimental approaches. Bone. September 2020;138:115159.
2021	Saha PK, Oweis RR, Zhang X, Letuchy E, Eichenberger-Gilmore JM, Burns TL, Warren JJ, Janz KF, Torner JC, Snetselaar LG, Levy SM. Effects of fluoride intake on cortical and trabecular bone microstructure at early adulthood using multi-row detector computed tomography (MDCT). Bone. May 2021;146:115882.
1989	Mellish RWE, Garraha NJ, Compston JE. Age-related changes in trabecular width and spacing in human iliac crest biopsies. Bone Miner. July 1989;6(3):331-338.
1989	Compston JE, Mellish RWE, Croucher P, Newcombe R, Garrahan NJ. Structural mechanisms of trabecular bone loss in man. Bone Miner. July 1989;6(3):339-350.
1990	Mosekilde L. Consequences of the remodelling process for vertebral trabecular bone structure: a scanning electron microscopy study (uncoupling of unloaded structures). Bone Miner. July 1990;10(1):13-35.
1990	Kimmel DB, Recker RR, Gallagher JC, Vaswani AS, Aloia JF. A comparison of iliac bone histomorphometric data in post-menopausal osteoporotic and normal subjects. Bone Miner. November 1990;11(2):217-235.
1988	Bergot C, Laval-Jeantet A-M, Prêteux F, Meunier A. Measurement of anisotropic vertebral trabecular bone loss during aging by quantitative image analysis. Calcif Tiss Int. September 1988;43(3):143-149.
1990	Mazess RB. Fracture risk: a role for compact bone. Calcif Tiss Int. October 1990;47(4):191-193.
1992	Chevalier F, Laval-Jeantet AM, Laval-Jeantet M, Bergot C. CT image analysis of the vertebral trabecular network in vivo. Calcif Tiss Int. July 1992;51(1):8-13.
1993	Heaney RP. Is there a role for bone quality in fragility fractures? Calcif Tiss Int. February 1993;53(suppl 1):S3-S6.
1993	Cooper C. The epidemiology of fragility fractures: is there a role for bone quality? Calcif Tiss Int. February 1993;53(suppl 1):S23-S26.
1993	Parfitt AM. Bone age, mineral density, and fatigue damage. Calcif Tiss Int. February 1993;53(suppl 1):S82-S86.
1993	Mosekilde L. Vertebral structure and strength in vivo and in vitro. Calcif Tiss Int. February 1993;53(suppl 1):S121-S126.
1993	Flynn MJ, Cody DD. The assessment of vertebral bone macroarchitecture with x-ray computed tomography. Calcif Tiss Int. February 1993;53(suppl 1):S170-S175.
1997	Uchiyama T, Tanizawa T, Muramatsu H, Endo N, Takahashi HE, Hara T. A morphometric comparison of trabecular structure of human ilium between microcomputed tomography and conventional histomorphometry. Calcif Tiss Int. December 1997;61(6):493-498.
2003	Ding M, Day JS, Burr DB, Mashiba T, Hirano T, Weinans H, Sumner DR, Hvid I. Canine cancellous bone microarchitecture after one year of high-dose bisphosphonates. Calcif Tiss Int. June 2003;72(6):737-744.
2003	Dufresne TE, Chmielewski PA, Manhart MD, Johnson TD, Borah B. Risedronate preserves bone architecture in early postmenopausal women in 1 year as measured by three-dimensional microcomputed tomography. Calcif Tiss Int. November 2003;73(5):423-432.
1987	Parfitt AM. Bone remodeling and bone loss: understanding the pathophysiology of osteoporosis. Clin Obstet Gynecol. December 1987;30(4):789-811.
2011	Cole JH, van der Meulen MCH. Whole bone mechanics and bone quality. Clin Orthop Relat Res. August 2011;469(8):2139-2149.
1993	Dempster DW, Cosman F, Parisien M, Shen V, Lindsay R. Anabolic actions of parathyroid hormone on bone. Endocr Rev. December 1993;14(6):690-709.
2010	Manolagas SC. From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev. June 2010;31(3):266-300.
1994	Hollister SJ, Brennan JM, Kikuchi N. A homogenization sampling procedure for calculating trabecular bone effective stiffness and tissue level stres. J Biomech. 1994;27(4):433-444.
2004	Nazarian A, Müller R. Time-lapsed microstructural imaging of bone failure behavior. J Biomech. 2004;37(1):55-65.
2008	Nazarian A, Bauernschmitt M, Eberle C, Meier D, Müller R, Snyder BD. Design and validation of a testing system to assess torsional cancellous bone failure in conjunction with time-lapsed micro-computed tomographic imaging. J Biomech. December 5, 2008;41(16):3496-3501.
1988	Recker RR, Kimmel DB, Parfitt MA, Davies MK, Keshawarz N, Hinders S. Static and tetracycline‐based bone histomorphometric data from 34 normal postmenopausal females. J Bone Miner Res. April 1988;3(2):133-344.
1995	Kinney JH, Lane NE, Haupt DL. In vivo, three‐dimensional microscopy of trabecular bone. J Bone Miner Res. February 1995;10(2):264-270.
1995	Chung H, Wehrli FW, Williams JL, Wehrli SL. Three‐dimensional nuclear magnetic resonance microimaging of trabecular bone. J Bone Miner Res. October 1995;10(10):1452-1461.
1996	Amling M, Herden S, Pösl M, Hahn M, Ritzel H, Delling G. Heterogeneity of the skeleton: comparison of the trabecular microarchitecture of the spine, the iliac crest, the femur, and the calcaneus. J Bone Miner Res. January 1996;11(1):36-45.
1996	Han Z, Palnitkar S, Rao DS, Nelson D, Parfitt AM. Effect of ethnicity and age or menopause on the structure and geometry of iliac bone. J Bone Miner Res. December 1996;11(12):1967-1975.
1997	Ritzel H, Amling M, Pösl M, Hahn M, Delling G. The thickness of human vertebral cortical bone and its changes in aging and osteoporosis: a histomorphometric analysis of the complete spinal column from thirty‐seven autopsy specimens. J Bone Miner Res. January 1997;12(1):89-95.
1997	Majumdar S, Genant HK, Grampp S, Newitt DC, Truong V-H, Lin JC, Mathur A. Correlation of trabecular bone structure with age, bone mineral density, and osteoporotic status: in vivo studies in the distal radius using high resolution magnetic resonance imaging. J Bone Miner Res. January 1997;12(1):111-118.
2000	Ciarelli TE, Fyhrie DP, Schaffler MB, Goldstein SA. Variations in three‐dimensional cancellous bone architecture of the proximal femur in female hip fractures and in controls. J Bone Miner Res. 2000;15(1):32-40.
2000	Oleksik A, Ott SM, Vedi S, Bravenboer N, Compston J, Lips P. Bone structure in patients with low bone mineral density with or without vertebral fractures. J Bone Miner Res. July 2000;15(7):1368-1375.
2000	Borah B, Dufresne TE, Cockman MD, Gross GJ, Sod EW, Myers WR, Combs KS, Higgins RE, Pierce SA, Stevens ML. Evaluation of changes in trabecular bone architecture and mechanical properties of minipig vertebrae by three‐dimensional magnetic resonance microimaging and finite element modeling. J Bone Miner Res. September 2000;15(9):1786-1797.
2001	Simpson EK, Parkinson IH, Manthey B, Fazzalari NL. Intervertebral disc disorganization is related to trabecular bone architecture in the lumbar spine. J Bone Miner Res. April 2001;16(4):681-687.
2001	Wehrli FW, Gomberg BR, Saha PK, Song HK, Hwang SN, Snyder PJ. Digital topological analysis of in vivo magnetic resonance microimages of trabecular bone reveals structural implications of osteoporosis. J Bone Miner Res. October 2001;16(8):1520-1531.
2002	Sarkar S, Mitlak BH, Wong M, Stock JL, Black DM, Harper KD. Relationships between bone mineral density and incident vertebral fracture risk with raloxifene therapy. J Bone Miner Res. January 2002;17(1):1-10.
2002	Halloran BP, Ferguson VL, Simske SJ, Burghardt A, Venton LL, Majumdar S. Changes in bone structure and mass with advancing age in the male C57BL/6J mouse. J Bone Miner Res. June 2002;17(6):1044-1050.
2002	Borah B, Dufresne TE, Chmielewski PA, Gross GJ, Prenger MC, Phipps RJ. Risedronate preserves trabecular architecture and increases bone strength in vertebra of ovariectomized minipigs as measured by three‐dimensional microcomputed tomography. J Bone Miner Res. July 2002;17(7):1139-1147.
2002	Nuzzo S, Lafage‐Proust MH, Martin‐Badosa E, Boivin G, Thomas T, Alexandre C, Peyrin F. Synchrotron radiation microtomography allows the analysis of three‐dimensional microarchitecture and degree of mineralization of human iliac crest biopsy specimens: effects of etidronate treatment. J Bone Miner Res. August 2002;17(8):1372-1382.
2003	David V, Laroche N, Boudignon B, Lafage‐Proust M, Alexandre C, Ruegsegger P, Vico L. Noninvasive in vivo monitoring of bone architecture alterations in hindlimb‐unloaded female rats using novel three‐dimensional microcomputed tomography. J Bone Miner Res. September 2003;18(9):1622-1631.
2006	Stauber M, Rapillard L, van Lenthe GH, Zysset P, Müller R. Importance of individual rods and plates in the assessment of bone quality and their contribution to bone stiffness. J Bone Miner Res. April 2006;21(4):586-595.
2007	Sornay‐Rendu E, Boutroy S, Munoz F, Delmas PD. Alterations of cortical and trabecular architecture are associated with fractures in postmenopausal women, partially independent of decreased BMD measured by DXA: the OFELY study. J Bone Miner Res. March 2007;22(3):425-433.
2008	Kazakia GJ, Hyun B, Burghardt AJ, Krug R, Newitt DC, de Papp AE, Link TM, Majumdar S. In vivo determination of bone structure in postmenopausal women: a comparison of MR‐pQCT and high‐field MR imaging. J Bone Miner Res. 2008;23(4):463-474.
2009	Sornay-Rendu E, Cabrera-Bravo J-L, Boutroy S, Munoz F, Delmas PD. Severity of vertebral fractures is associated with alterations of cortical architecture in postmenopausal women. J Bone Miner Res. April 2009;24(4):737-743.
2011	Szulc P, Boutroy S, Vilayphiou N, Chaitou A, Delmas PD, Chapurlat R. Cross-sectional analysis of the association between fragility fractures and bone microarchitecture in older men: the STRAMBO study. J Bone Miner Res. June 2011;26(6):1358-1367.
1993	Bonadio J, Jepsen KJ, Mansoura MK, Jaenisch R, Kuhn JL, Goldstein SA. A murine skeletal adaptation that significantly increases cortical bone mechanical properties: implications for human skeletal fragility. J Clin Invest. October 1993;92(4):1697-1705.
2005	Thomsen JS, Laib A, Koller B, Prohaska S, Mosekilde L, Gowin W. Stereological measures of trabecular bone structure: comparison of 3D micro computed tomography with 2D histological sections in human proximal tibial bone biopsies. J Microsc (Oxford). 2005;218(2):171-179.
1988	Ruff CB, Hayes WC. Sex differences in age‐related remodeling of the femur and tibia. J Orthop Res. November 1988;6(6):886-896.
1998	Ladd AJC, Kinney JH, Haupt DL, Goldstein SA. Finite‐element modeling of trabecular bone: comparison with mechanical testing and determination of tissue modulus. J Orthop Res. September 1998;16(5):622-628.
2000	Guo XE, Goldstein SA. Vertebral trabecular bone microscopic tissue elastic modulus and hardness do not change in ovariectomized rats. J Orthop Res. March 2000;18(2):333-336.
2002	Ding M, Odgaard A, Linde F, Hvid I. Age-related variations in the microstructure of human tibial cancellous bone. J Orthop Res. May 2002;20(3):615-621.
1993	Jara H, Wehrli FW, Chung H, Ford JC. High-resolution variable flip angle 3D MR imaging of trabecular microstructure in vivo. Mag Reson Med. April 1993;29(4):528-539.
2000	Laib A, Barou O, Vico L, Lafage-Proust MH, Alexandre C, Rügsegger P. 3D micro-computed tomography of trabecular and cortical bone architecture with application to a rat model of immobilisation osteoporosis. Med Biol Eng Comput. May 2000;38(3):326-332.
1995	Müller R, Rüegsegger P. Three-dimensional finite element modelling of non-invasively assessed trabecular bone structures. Med Eng Phys. March 1995;17(2):126-133.
2007	MacNeil JA, Boyd SK. Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med Eng Phys. December 2007;29(10):1096-1105.
2008	Klinck RJ, Campbell GM, Boyd SK. Radiation effects on bone architecture in mice and rats resulting from in vivo micro-computed tomography scanning. Med Eng Phys. September 2008;30(7):888-895.
1997	Hwang SN, Wehrli FW, Williams JL. Probability‐based structural parameters from three‐dimensional nuclear magnetic resonance images as predictors of trabecular bone strength. Med Phys. August 1997;24(8):1255-1261.
2002	Nuzzo S, Peyrin F, Cloetens P, Baruchel J, Boivin G. Quantification of the degree of mineralization of bone in three dimensions using synchrotron radiation microtomography. Med Phys. November 2002;29(11):2672-2681.
2008	Kazakia GJ, Burghardt AJ, Cheung S, Majumdar S. Assessment of bone tissue mineralization by conventional x-ray microcomputed tomography: comparison with synchrotron radiation microcomputed tomography and ash measurements. Med Phys. 2008;35(7):3170-3179.
1993	Dempster DW, Ferguson-Pell MW, Mellish RWE, Cochran GVB, Xie F, Fey C, Horbert W, Parisien M, Lindsay R. Relationships between bone structure in the iliac crest and bone structure and strength in the lumbar spine. Osteoporos Int. March 1993;3(2):90-96.
1998	Gordon CL, Lang TF, Augat P, Genant HK. Image-based assessment of spinal trabecular bone structure from high-resolution CT images. Osteoporos Int. August 1998;8(4):317-325.
2006	Stauber M, Müller R. Age-related changes in trabecular bone microstructures: global and local morphometry. Osteoporos Int. April 2006;17(4):616-626.
1994	Müller R, Hildebrand T, Rüegsegger P. Non-invasive bone biopsy: a new method to analyse and display the three-dimensional structure of trabecular bone. Phys Med Biol. January 1994;39(1):145-164.
1996	Gordon CL, Webber CE, Adachi JD, Christoforou N. In vivo assessment of trabecular bone structure at the distal radius from high-resolution computed tomography images. Phys Med Biol. March 1996;41(3):495-508.
1993	Chung H, Wehrli FW, Williams JL, Kugelmass SD. Relationship between NMR transverse relaxation, trabecular bone architecture, and strength. Proc Natl Acad Sci USA. November 1993;90(5):10250-10254.
1998	Wehrli FW, Hwang SN, Ma J, Song HK, Ford JC, Haddad JG. Cancellous bone volume and structure in the forearm: noninvasive assessment with MR microimaging and image processing. Radiology. February 1998;206(2):347-357.
1996	Müller R, Koller B, Hildebrand T, Laib A, Gianolini S, Rüegsegger P. Resolution dependency of microstructural properties of cancellous bone based on three-dimensional μ-tomography. Technol Health Care. April 1996;4(1):113-119.
1998	Majumdar S. A review of magnetic resonance (MR) imaging of trabecular bone micro-architecture: contribution to the prediction of biomechanical properties and fracture prevalence. Technol Health Care. 1998;6(5-6):321-327.
1998	Dufresne T. Segmentation techniques for analysis of bone by three-dimensional computed tomographic imaging. Technol Health Care. 1998;6(5-6):351-359.
2011	Cotter MM. Gross Morphology, Microarchitecture, Strength and Evolution of the Hominoid Vertebral Body [PhD thesis]. Cleveland, OH: Case Western Reserve University; May 2011.
2003	Kim CH. In Vivo Trabecular Bone Response to Mechanical Loading and Parathyroid Hormone Stimulation [PhD thesis]. Columbia University; 2003.
2005	Day JS. Bone Quality: The Mechanical Effects of Microarchitecture and Matrix Properties [PhD thesis]. Erasmus University Rotterdam; 2005.
1999	Laib A. Microarchitecture of the Human Radius Assessed With High Resolution in Vivo 3D-QCT [PhD thesis]. Swiss Federal Institute of Technology Zürich; 1999.
2005	Stauber M. Volumetric Spatial Decomposition of Porous Microstructures: A Framework for Element Based Analysis of Trabecular Bone [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2005.
2007	Schneider P. Ultrastructural Phenotyping of Murine Bone Using Synchrotron Micro- and Nano-Computed Tomography [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2007.
2008	Nazarian A. Relative Interaction of Material and Structure in Normal and Pathologic Bone [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2008.
2010	Müller T. Bioimaging and Biomechanics of Bone Competence and Implant Stability [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2010.
2012	Christen DB. Nonlinear Failure Prediction in Human Bone: A Clinical Approach Based on High Resolution Imaging [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2012.
2020	Bennison MBL. The Role of Cancellous Bone Architecture in Misalignment and Side Effect Errors [Master's thesis]. Sudbury, ON: Laurentian University; 2020.
2007	Akhtar R. Micromechanical Behaviour of Bone [PhD thesis]. University of Manchester; 2007.
1997	Flynn TW. Tibial Flexural Wave Propagation Velocity in Vivo: Methodological Considerations in the Analysis of Bone Quality [PhD thesis]. State College, PA: Pennsylvania State University; August 1997.
2005	Buie HR. Use of Finite Element Method Modelling and Rapid Prototyping to Study the Effect of Trabecular Bone Architecture on Apparent Mechanical Properties [Master's thesis]. Queen's University; November 2005.
2021	Frank M. Mechanical Characterization of Individual Trabeculae [PhD thesis]. Vienna University of Technology; February 2021.
2005	Sran MM. Manual Therapy and the Osteoporotic Spine [PhD thesis]. Vancouver, BC: University of British Columbia; March 2005.
2006	Macdonald HM. Effectiveness of a School-Based Physical Activity Intervention for Increasing Bone Strength in Children: Action Schools! British Columbia [PhD thesis]. Vancouver, BC: University of British Columbia; July 2006.
2014	Colombo A. La micro-architecture de l’os trabéculaire en croissance: Variabilité tridimensionnelle normale et pathologique analysée par microtomodensitométrie [PhD thesis]. Université de Bordeaux; December 15, 2014.
2007	Klinck RJ. Establishing in Vivo Micro-CT for Use in Mouse Models of Osteoprosis [Master's thesis]. Calgary, AB: University of Calgary; December 2007.
2007	MacNeil JAM. Clinical Assessment of Bone Quality [PhD thesis]. Calgary, AB: University of Calgary; June 2007.
2020	Michalski AS. A Quantitative Computed Tomography Approach Towards Opportunistic Osteoporosis Screening [PhD thesis]. Calgary, AB: University of Calgary; March 2020.
2003	Fox JC. Biomechanics of the Proximal Femur: Role of Bone Distribution and Architecture [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2003.
2016	Chen C. Mechanical and Micro-Structural Modeling of Trabecular Bone by in Vivo Imaging [PhD thesis]. University of Iowa; December 2016.
2018	Oweis R. Associations Between Fluoride Intakes, Bone Outcomes and Dental Fluorosis [PhD thesis]. University of Iowa; May 2018.
2022	Zhang X. Development of an Image-Based System for Assessment of Bone Density, Geometry, and Micro-Architecture Suitable for Human Studies [PhD thesis]. University of Iowa; August 2022.
1993	McCubbrey DA. The Macroscopic Architectural Properties of Vertebral Trabecular Bone and Their Relation to Whole Vertebral Failure Loads [PhD thesis]. University of Michigan; 1993.
1998	Ciarelli TE. Architectural and Material Contributions to Fracture of the Spine and Proximal Femur [PhD thesis]. University of Michigan; 1998.
1995	Grimm MJ. Ultrasound Propagation Through the Calcaneus: Dependence on "Bone Quality" and Prediction by Biot's Theory [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 1995.
2010	Wald MJ. Mapping Trabecular Bone Fabric Tensor by in Vivo Magnetic Resonance Imaging [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2010.
2016	Andronowski JM. Evaluating Differential Nuclear DNA Yield Rates Among Human Bone Tissue Types: A Synchrotron Micro-CT Approach [PhD thesis]. Knoxville, University of Tennessee; May 2016.
2018	Burke MV. Quantification of Changes in Vertebral Bone Quality in the Presence of Metastases [PhD thesis]. University of Toronto; 2018.
2005	Cao KD. Development of a 4-Vertebrae, Detailed Finite Element Model of Thoracolumbar Spine [PhD thesis]. Detroit, MI: Wayne State University; August 2005.

Year	Entry
1966	Weaver JK, Chalmers J. Cancellous bone: its strength and changes with aging and an evaluation of some methods for measuring its mineral content, I: age changes in cancellous bone. J Bone Joint Surg. March 1966;48A(2):289-298.
1985	Cann CE, Genant HK, Kolb FO, Ettinger B. Quantitative computed tomography for prediction of vertebral fracture risk. Bone. 1985;6(1):1-7.
1982	Riggs BL, Wahner HW, Seeman E, Offord KP, Dunn WL, Mazess RB, Johnson KA, Melton LJ III. Changes in bone mineral density of the proximal femur and spine with aging: differences between the postmenopausal and senile osteoporosis syndromes. J Clin Invest. October 1982;70(4):716-723.
1980	Hansson T, Roos B, Nachemson A. The bone mineral content and ultimate compressive strength of lumbar vertebrae. Spine. January–February 1980;5(1):46-55.
1984	Parfitt AM. Age-related structural changes in trabecular and cortical bone: cellular mechanisms and biomechanical consequences. Calcif Tiss Int. 1984;36(suppl 1):S123-S128.
1977	Whitehouse WJ. Cancellous bone in the anterior part of the iliac crest. Calcif Tiss Res. December 1977;23(1):67-76.
1975	Smith DM, Khairi MR, Johnston CC Jr. The loss of bone mineral with aging and its relationship to risk of fracture. J Clin Invest. August 1975;56(2):311-318.
1974	Pugh JW, Radin EL, Rose RM. Quantitative studies of human subchondral cancellous bone: its relationship to the state of tts overlying cartilage. J Bone Joint Surg. March 1974;56A(2):313-321.
1983	Parfitt AM, Mathews CH, Villanueva AR, Kleerekoper M, Frame B, Rao DS. Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis: implications for the microanatomic and cellular mechanisms of bone loss. J Clin Invest. October 1983;72(4):1396-1409.