This paper focuses on the overall structure of the Crash Injury Research and Engineering Network (CIREN), how data are collected, and what makes it unique. It discusses how it can be used to expand and enhance the information in other databases. CIREN is a collaborative effort to conduct research on crashes and injuries at nine Level 1 Trauma Centers which are linked by a computer network. Researchers can review data and share expertise, which will lead to a better understanding of crash injury mechanisms and the design of safer vehicles. CIREN data are being used in outreach and education programs on motor vehicle safety. CIREN outreach and education has already been credited with lifesaving information dissemination.